{"id":9656,"date":"2017-06-01T00:00:00","date_gmt":"2018-12-03T17:13:37","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gut-derived-serum-lipopolysaccharide-is-associated-with\/"},"modified":"2018-12-03T18:13:37","modified_gmt":"2018-12-03T17:13:37","slug":"gut-derived-serum-lipopolysaccharide-is-associated-with","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gut-derived-serum-lipopolysaccharide-is-associated-with\/","title":{"rendered":"Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>BACKGROUND<\/strong><br \/>\nGut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut-derived lipopolysaccharide (LPS) is unknown. We analyzed (1) the association between LPS and major adverse cardiovascular events (MACE) in atrial fibrillation (AF) and (2) its relationship with adherence to a Mediterranean diet (Med-diet).<\/p>\n<p style=\"text-align:justify\"><strong>METHODS AND RESULTS<\/strong><br \/>\nThis was a prospective single-center study including 912 AF patients treated with vitamin K antagonists (3716 patient-years). The primary end point was a composite of MACE. Baseline serum LPS, adherence to Med-diet (n=704), and urinary excretion of 11-dehydro-thromboxane B2 (TxB2, n=852) were investigated. Mean age was 73.5&nbsp;years; 42.9% were women. A total of 187 MACE (5.0% per year) occurred: 54, 59, and 74 in the first, second, and third tertile of LPS, respectively (log-rank test P=0.004). Log-LPS (hazard ratio 1.194, P=0.009), age (hazard ratio 1.083, P&lt;0.001), and previous cerebrovascular (hazard ratio 1.634, P=0.004) and cardiac events (hazard ratio 1.822, P&lt;0.001) were predictors of MACE. In the whole cohort, AF (versus sinus rhythm) (&beta; 0.087, P=0.014) and low-density lipoprotein cholesterol (&beta; 0.069, P=0.049) were associated with circulating LPS. Furthermore, Med-diet score (&beta; -0.137, P&lt;0.001) was predictive of log-LPS, with fruits (&beta; -0.083, P=0.030) and legumes (&beta; -0.120, P=0.002) negatively associated with log-LPS levels. Log-LPS and log-TxB2 were highly correlated (r=0.598, P&lt;0.001). Log-LPS (&beta; 0.574, P&lt;0.001) and Med-diet score (&beta; -0.218, P&lt;0.001) were significantly associated with baseline urinary excretion of TxB2.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS<\/strong><br \/>\nIn this cohort of AF patients, LPS levels were predictive of MACE and negatively affected by high adherence to Med-diet. LPS may contribute to MACE incidence in AF by increasing platelet activation.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-9656","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"I Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Italy.","annee":"2017","mois":"6","numero":"6:6","page":"","auteurs":[{"ID":9647,"post_author":"0","post_date":"2018-12-03 18:13:32","post_date_gmt":"2018-12-03 17:13:32","post_content":"","post_title":"Daniele Pastori","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"daniele-pastori","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:32","post_modified_gmt":"2018-12-03 17:13:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/daniele-pastori\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9648,"post_author":"0","post_date":"2018-12-03 18:13:33","post_date_gmt":"2018-12-03 17:13:33","post_content":"","post_title":"Roberto Carnevale","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"roberto-carnevale","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:33","post_modified_gmt":"2018-12-03 17:13:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/roberto-carnevale\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9649,"post_author":"0","post_date":"2018-12-03 18:13:33","post_date_gmt":"2018-12-03 17:13:33","post_content":"","post_title":"Cristina Nocella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cristina-nocella","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:33","post_modified_gmt":"2018-12-03 17:13:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cristina-nocella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9650,"post_author":"0","post_date":"2018-12-03 18:13:34","post_date_gmt":"2018-12-03 17:13:34","post_content":"","post_title":"Francesco Violi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francesco-violi","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:34","post_modified_gmt":"2018-12-03 17:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/francesco-violi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9651,"post_author":"0","post_date":"2018-12-03 18:13:34","post_date_gmt":"2018-12-03 17:13:34","post_content":"","post_title":"Pasquale Pignatelli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pasquale-pignatelli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:34","post_modified_gmt":"2018-12-03 17:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pasquale-pignatelli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9652,"post_author":"0","post_date":"2018-12-03 18:13:35","post_date_gmt":"2018-12-03 17:13:35","post_content":"","post_title":"Danilo Menichelli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"danilo-menichelli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:35","post_modified_gmt":"2018-12-03 17:13:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/danilo-menichelli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9653,"post_author":"0","post_date":"2018-12-03 18:13:35","post_date_gmt":"2018-12-03 17:13:35","post_content":"","post_title":"Marta Novo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marta-novo","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:35","post_modified_gmt":"2018-12-03 17:13:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marta-novo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9654,"post_author":"0","post_date":"2018-12-03 18:13:36","post_date_gmt":"2018-12-03 17:13:36","post_content":"","post_title":"Maria Santulli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maria-santulli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:36","post_modified_gmt":"2018-12-03 17:13:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/maria-santulli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9655,"post_author":"0","post_date":"2018-12-03 18:13:36","post_date_gmt":"2018-12-03 17:13:36","post_content":"","post_title":"Vittoria Cammisotto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"vittoria-cammisotto","to_ping":"","pinged":"","post_modified":"2018-12-03 18:13:36","post_modified_gmt":"2018-12-03 17:13:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/vittoria-cammisotto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":6043,"post_author":"0","post_date":"2018-12-03 17:34:13","post_date_gmt":"2018-12-03 16:34:13","post_content":"","post_title":"Journal of the American Heart Association","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-the-american-heart-association","to_ping":"","pinged":"","post_modified":"2018-12-03 17:34:13","post_modified_gmt":"2018-12-03 16:34:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-the-american-heart-association\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet. - Aprifel<\/title>\n<meta name=\"description\" content=\"Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" 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