{"id":7736,"date":"2018-02-01T00:00:00","date_gmt":"2018-12-03T16:52:23","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dietary-antioxidant-capacity-and-risk-of-type-2-diabetes-in\/"},"modified":"2018-12-03T17:52:23","modified_gmt":"2018-12-03T16:52:23","slug":"dietary-antioxidant-capacity-and-risk-of-type-2-diabetes-in","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dietary-antioxidant-capacity-and-risk-of-type-2-diabetes-in\/","title":{"rendered":"Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort."},"content":{"rendered":"<p style=\"text-align:justify\"><strong>AIMS\/HYPOTHESIS<\/strong><br \/>\nRecent evidence suggests that oxidative stress may contribute to the pathogenesis of type 2 diabetes. The diet, and especially fruit and vegetables, contains a variety of compounds with antioxidant activity, which may have cumulative\/synergistic antioxidant effects. The total antioxidant capacity, an index derived from dietary intake, is a single estimate of antioxidant capacity from all dietary antioxidants. The main aim of this study was to investigate the relationship between total antioxidant capacity and risk of type 2 diabetes.<\/p>\n<p style=\"text-align:justify\"><strong>METHODS<\/strong><br \/>\nAmong 64,223 women (mean age 52&nbsp;&plusmn;&nbsp;7&nbsp;years) from the French E3N-European Prospective Investigation into Cancer and Nutrition (<span class='tooltipsall tooltip_post_id_80438 classtoolTips80438'>EPIC<\/span>) cohort, 1751 women had validated type 2 diabetes during 15&nbsp;years of follow-up. The total antioxidant capacity was estimated with the ferric ion-reducing antioxidant power (FRAP) method. Adjusted Cox proportional hazards regression models were used to calculate HRs and 95% CIs for the associations between total antioxidant capacity and type 2 diabetes risk, adjusted for potential confounders.<\/p>\n<p style=\"text-align:justify\"><strong>RESULTS<\/strong><br \/>\nIn multivariable models, higher levels of total antioxidant capacity were associated with a lower risk of type 2 diabetes. Compared with women in the lowest quintile, women in the third, fourth and fifth quintiles for total antioxidant capacity had HRs of 0.74 (95% CI 0.63, 0.86), 0.70 (95% CI 0.59, 0.83) and 0.73 (95% CI 0.60, 0.89), respectively. The inverse association between total antioxidant capacity and risk of type 2 diabetes was linear up to values of 15&nbsp;mmol\/day, after which the effect reached a plateau.<\/p>\n<p style=\"text-align:justify\"><strong>CONCLUSIONS\/INTERPRETATION<\/strong><br \/>\nOur findings suggest that the total antioxidant capacity may play an important role in reducing the risk of type 2 diabetes in middle-aged women. More studies are warranted to better understand the biological mechanisms underlying this inverse association.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-7736","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Inserm U1018, Centre for Research in Epidemiology and Population Health (CESP) 'Health across Generations' Team, University Paris-Saclay, University Paris-Sud, Gustave Roussy, Espace Maurice Tubiana, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.","annee":"2018","mois":"2","numero":"61:2","page":"308-316","auteurs":[{"ID":1393,"post_author":"0","post_date":"2018-12-03 15:58:57","post_date_gmt":"2018-12-03 14:58:57","post_content":"","post_title":"Guy Fagherazzi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"guy-fagherazzi","to_ping":"","pinged":"","post_modified":"2018-12-03 15:58:57","post_modified_gmt":"2018-12-03 14:58:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/guy-fagherazzi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6657,"post_author":"0","post_date":"2018-12-03 17:40:30","post_date_gmt":"2018-12-03 16:40:30","post_content":"","post_title":"Aur\u00e9lie Affret","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"aurelie-affret","to_ping":"","pinged":"","post_modified":"2018-12-03 17:40:30","post_modified_gmt":"2018-12-03 16:40:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/aurelie-affret\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3008,"post_author":"0","post_date":"2018-12-03 17:01:20","post_date_gmt":"2018-12-03 16:01:20","post_content":"","post_title":"Courtney Dow","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"courtney-dow","to_ping":"","pinged":"","post_modified":"2018-12-03 17:01:20","post_modified_gmt":"2018-12-03 16:01:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/courtney-dow\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3009,"post_author":"0","post_date":"2018-12-03 17:01:21","post_date_gmt":"2018-12-03 16:01:21","post_content":"","post_title":"Marie-Christine Boutron-Ruault","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marie-christine-boutron-ruault-2","to_ping":"","pinged":"","post_modified":"2018-12-03 17:01:21","post_modified_gmt":"2018-12-03 16:01:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marie-christine-boutron-ruault-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3010,"post_author":"0","post_date":"2018-12-03 17:01:21","post_date_gmt":"2018-12-03 16:01:21","post_content":"","post_title":"Fabrice Bonnet","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fabrice-bonnet","to_ping":"","pinged":"","post_modified":"2018-12-03 17:01:21","post_modified_gmt":"2018-12-03 16:01:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fabrice-bonnet\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3011,"post_author":"0","post_date":"2018-12-03 17:01:22","post_date_gmt":"2018-12-03 16:01:22","post_content":"","post_title":"Francesca Romana Mancini","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"francesca-romana-mancini","to_ping":"","pinged":"","post_modified":"2018-12-03 17:01:22","post_modified_gmt":"2018-12-03 16:01:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/francesca-romana-mancini\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3012,"post_author":"0","post_date":"2018-12-03 17:01:22","post_date_gmt":"2018-12-03 16:01:22","post_content":"","post_title":"Beverley Balkau","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"beverley-balkau","to_ping":"","pinged":"","post_modified":"2018-12-03 17:01:22","post_modified_gmt":"2018-12-03 16:01:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/beverley-balkau\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1351,"post_author":"0","post_date":"2018-12-03 15:58:34","post_date_gmt":"2018-12-03 14:58:34","post_content":"","post_title":"Diabetologia","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"diabetologia","to_ping":"","pinged":"","post_modified":"2018-12-03 15:58:34","post_modified_gmt":"2018-12-03 14:58:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/diabetologia\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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