{"id":7535,"date":"2018-01-01T00:00:00","date_gmt":"2018-12-03T16:50:14","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/"},"modified":"2018-12-03T17:50:14","modified_gmt":"2018-12-03T16:50:14","slug":"advances-in-understanding-the-molecular-basis-of-the-mediterranean","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/","title":{"rendered":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect."},"content":{"rendered":"<p style=\"text-align:justify\">Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. The scientific evidence level for each outcome is variable, and new studies are needed to better understand the molecular mechanisms whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases but also discussing other related diseases. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. We review MedDiet composition and assessment as well as the latest advances in the genomic, epigenomic (DNA methylation, histone modifications, microRNAs, and other emerging regulators), transcriptomic (selected genes and whole transcriptome), and metabolomic and metagenomic aspects of the MedDiet effects (as a whole and for its most typical food components). We also present a critical review of the limitations of the studies undertaken and propose new analyses and greater bioinformatic integration to better understand the most important molecular mechanisms whereby the MedDiet as a whole, or its main food components, may exercise their protective effects. Expected final online publication date for the Annual Review of Food Science and Technology Volume 9 is March 25, 2018. Please see http:\/\/www.annualreviews.org\/page\/journal\/pubdates for revised estimates.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-7535","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Preventative Medicine and Public Health, School of Medicine, University of Valencia, Valencia, 46010, Spain; email: Dolores.Corella@uv.es.","annee":"2018","mois":"1","numero":"","page":"","auteurs":[{"ID":4533,"post_author":"0","post_date":"2018-12-03 17:18:24","post_date_gmt":"2018-12-03 16:18:24","post_content":"","post_title":"Dolores Corella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dolores-corella","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:24","post_modified_gmt":"2018-12-03 16:18:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dolores-corella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7531,"post_author":"0","post_date":"2018-12-03 17:50:12","post_date_gmt":"2018-12-03 16:50:12","post_content":"","post_title":"Oscar Coltell","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"oscar-coltell","to_ping":"","pinged":"","post_modified":"2018-12-03 17:50:12","post_modified_gmt":"2018-12-03 16:50:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/oscar-coltell\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7532,"post_author":"0","post_date":"2018-12-03 17:50:13","post_date_gmt":"2018-12-03 16:50:13","post_content":"","post_title":"Jose M Ordovas","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jose-m-ordovas","to_ping":"","pinged":"","post_modified":"2018-12-03 17:50:13","post_modified_gmt":"2018-12-03 16:50:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jose-m-ordovas\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7533,"post_author":"0","post_date":"2018-12-03 17:50:13","post_date_gmt":"2018-12-03 16:50:13","post_content":"","post_title":"Fernando Macian","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fernando-macian","to_ping":"","pinged":"","post_modified":"2018-12-03 17:50:13","post_modified_gmt":"2018-12-03 16:50:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fernando-macian\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":7534,"post_author":"0","post_date":"2018-12-03 17:50:14","post_date_gmt":"2018-12-03 16:50:14","post_content":"","post_title":"Annual review of food science and technology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"annual-review-of-food-science-and-technology","to_ping":"","pinged":"","post_modified":"2018-12-03 17:50:14","post_modified_gmt":"2018-12-03 16:50:14","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/annual-review-of-food-science-and-technology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel<\/title>\n<meta name=\"description\" content=\"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect.\" \/>\n<meta property=\"og:description\" content=\"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/\",\"name\":\"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-03T16:50:14+00:00\",\"dateModified\":\"2018-12-03T16:50:14+00:00\",\"description\":\"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel","description":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect.","og_description":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/","name":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-03T16:50:14+00:00","dateModified":"2018-12-03T16:50:14+00:00","description":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/advances-in-understanding-the-molecular-basis-of-the-mediterranean\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/7535"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=7535"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=7535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}