{"id":62232,"date":"2013-11-01T00:00:00","date_gmt":"2018-12-04T08:11:47","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/prospective-association-between-dietary-fiber-intake-and\/"},"modified":"2018-12-04T09:11:47","modified_gmt":"2018-12-04T08:11:47","slug":"prospective-association-between-dietary-fiber-intake-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/prospective-association-between-dietary-fiber-intake-and\/","title":{"rendered":"Prospective Association between Dietary Fiber Intake and Breast Cancer Risk."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>BACKGROUND<\/strong><br \/>\nMechanistic hypotheses suggest a potential effect of dietary fiber on breast carcinogenesis through the modulation of insulin-like growth factor bioactivity, estrogen metabolism and inflammation. An association between dietary fiber intake and breast cancer risk has been suggested in epidemiological studies but remains inconclusive. In particular, data is lacking regarding the different types of dietary fibers.<\/p>\n<p style=\"text-align: justify\"><strong>OBJECTIVE<\/strong><br \/>\nThe objective was to investigate the prospective relationship between dietary fiber intake and breast cancer risk, taking into account different types of dietary fiber (overall, insoluble, soluble and from different food sources: cereals, vegetables, fruits and legumes).<\/p>\n<p style=\"text-align: justify\"><strong>METHODS<\/strong><br \/>\n4684 women from the SU.VI.MAX cohort were included in this analysis as they completed at least three 24h-dietary records within the first two years of follow-up. Among them, 167 incident invasive breast cancers were diagnosed during a median follow-up of 12.6 years (between 1994 and 2007). The associations between quartiles of dietary fiber intake and breast cancer risk were characterized using multivariate Cox proportional hazards models.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS<\/strong><br \/>\nTotal fiber intake was not associated with breast cancer risk (HRQuartile4vs.Quartile1=1.29 (95%CI 0.66-2.50), P-trend=0.5), nor was fiber intake from cereals (P-trend=0.1), fruits (P-trend=0.9) and legumes (P-trend=0.3). In contrast, vegetable fiber intake was related to a decreased risk of breast cancer (HRQ4vs.Q1=0.50 (0.29-0.88), P-trend=0.03). Overall vegetable intake (in g\/day) was not associated with breast cancer risk (P-trend=0.2).<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS<\/strong><br \/>\nThis prospective study suggests that vegetable fiber intake may contribute to reduce breast cancer risk, in line with experimental mechanistic data.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-62232","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Nutritional Epidemiology Research Team, Sorbonne Paris Cit\u00e9 Research Center, Inserm (U557), Inra (U1125), Cnam, Paris 13 University, SMBH Paris 13, Bobigny, France.","annee":"2013","mois":"11","numero":"8:11","page":"e79718","auteurs":[{"ID":1134,"post_author":"0","post_date":"2018-12-03 15:56:39","post_date_gmt":"2018-12-03 14:56:39","post_content":"","post_title":"M\u00e9lanie Deschasaux","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"melanie-deschasaux","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:39","post_modified_gmt":"2018-12-03 14:56:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/melanie-deschasaux\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1135,"post_author":"0","post_date":"2018-12-03 15:56:40","post_date_gmt":"2018-12-03 14:56:40","post_content":"","post_title":"Laurent Zelek","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"laurent-zelek","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:40","post_modified_gmt":"2018-12-03 14:56:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/laurent-zelek\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1136,"post_author":"0","post_date":"2018-12-03 15:56:40","post_date_gmt":"2018-12-03 14:56:40","post_content":"","post_title":"Camille Pouchieu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"camille-pouchieu","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:40","post_modified_gmt":"2018-12-03 14:56:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/camille-pouchieu\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1137,"post_author":"0","post_date":"2018-12-03 15:56:41","post_date_gmt":"2018-12-03 14:56:41","post_content":"","post_title":"Mathilde His","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mathilde-his","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:41","post_modified_gmt":"2018-12-03 14:56:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mathilde-his\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1138,"post_author":"0","post_date":"2018-12-03 15:56:41","post_date_gmt":"2018-12-03 14:56:41","post_content":"","post_title":"Serge Hercberg","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"serge-hercberg","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:41","post_modified_gmt":"2018-12-03 14:56:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/serge-hercberg\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1139,"post_author":"0","post_date":"2018-12-03 15:56:42","post_date_gmt":"2018-12-03 14:56:42","post_content":"","post_title":"Pilar Galan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pilar-galan","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:42","post_modified_gmt":"2018-12-03 14:56:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pilar-galan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1140,"post_author":"0","post_date":"2018-12-03 15:56:42","post_date_gmt":"2018-12-03 14:56:42","post_content":"","post_title":"Paule Latino-Martel","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"paule-latino-martel","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:42","post_modified_gmt":"2018-12-03 14:56:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/paule-latino-martel\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1141,"post_author":"0","post_date":"2018-12-03 15:56:42","post_date_gmt":"2018-12-03 14:56:42","post_content":"","post_title":"Mathilde Touvier","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mathilde-touvier","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:42","post_modified_gmt":"2018-12-03 14:56:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mathilde-touvier\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1142,"post_author":"0","post_date":"2018-12-03 15:56:43","post_date_gmt":"2018-12-03 14:56:43","post_content":"","post_title":"PloS one","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"plos-one","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:43","post_modified_gmt":"2018-12-03 14:56:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/plos-one\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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