{"id":62199,"date":"2013-11-01T00:00:00","date_gmt":"2018-12-04T08:10:21","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-acute-and-longer-term-dietary-restriction-on-upper\/"},"modified":"2018-12-04T09:10:21","modified_gmt":"2018-12-04T08:10:21","slug":"effects-of-acute-and-longer-term-dietary-restriction-on-upper","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-acute-and-longer-term-dietary-restriction-on-upper\/","title":{"rendered":"Effects of acute and longer-term dietary restriction on upper gut motility, hormone, appetite, and energy-intake responses to duodenal lipid in lean and obese men."},"content":{"rendered":"<p><strong>BACKGROUND<\/strong><br \/>\nA 4-d 70% energy restriction enhances gastrointestinal sensitivity to nutrients associated with enhanced energy-intake suppression by lipid. To our knowledge, it is unknown whether these changes occur with 30% energy restriction and are sustained in the longer term.<\/p>\n<p><strong>OBJECTIVE<\/strong><br \/>\nWe hypothesized that 1) a 4-d 30% energy restriction would enhance effects of intraduodenal lipid on gastrointestinal motility, gut hormones, appetite, and energy intake in lean and obese men and 2) a 12-wk energy restriction associated with weight-loss would diminish effects of acute energy restriction on responses to lipid in in obese men.<\/p>\n<p><strong>METHODS<\/strong><br \/>\nTwelve obese males were studied before (day 0) and after 4 d (day 5), 4 wk (week 4), and 12 wk (week 12), and 12 lean males were studied before and after 4 d of consumption of a 30% energy-restricted diet. On each study day, antropyloroduodenal pressures, gut hormones, and appetite during a 120-min (2.86-kcal\/min) intraduodenal lipid infusion and energy intake at a buffet lunch were measured.<\/p>\n<p><strong>RESULTS<\/strong><br \/>\nOn day 5, fasting cholecystokinin was less, and ghrelin was higher, in lean (P &lt; 0.05) but not obese men, and lipid-stimulated cholecystokinin and peptide YY and the desire to eat were greater in both groups (P &lt; 0.05), with no differences in energy intakes compared with on day 0. In obese men, a 12-wk energy restriction led to weight loss (9.7 &plusmn; 0.7 kg). Lipid-induced basal pyloric pressures (BPPs), peptide-YY, and the desire to eat were greater (P &lt; 0.05), whereas the amount eaten was less (P &lt; 0.05), at weeks 4 and 12 compared with day 0.<\/p>\n<p><strong>CONCLUSIONS<\/strong><br \/>\nA 4-d 30% energy restriction modestly affects responses to intraduodenal lipid in health and obesity but not energy intake, whereas a 12-wk energy restriction, associated with weight-loss, enhances lipid-induced BPP and peptide YY and reduces food intake, suggesting that energy restriction increases gastrointestinal sensitivity to lipid.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-62199","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia (RVS, TJL, SS, MH, and CF-B); the National Health and Medical Research Council of Australia Centre of Research Excellence in Translating Nutritional Science to Good Health, Adelaide, Australia (RVS, TJL, MN, SS, PMC, MH, and CF-B); the Commomwealth Science and Industry Research Organisation Animal, Food and Health Science, Adelaide, Australia (PT and MN); and the University of South Australia, Adelaide, Australia (PMC).","annee":"2013","mois":"11","numero":"","page":"","auteurs":[{"ID":1734,"post_author":"0","post_date":"2018-12-03 16:02:04","post_date_gmt":"2018-12-03 15:02:04","post_content":"","post_title":"Radhika V Seimon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"radhika-v-seimon","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:04","post_modified_gmt":"2018-12-03 15:02:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/radhika-v-seimon\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1735,"post_author":"0","post_date":"2018-12-03 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Standfield","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"scott-standfield","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:06","post_modified_gmt":"2018-12-03 15:02:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/scott-standfield\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1739,"post_author":"0","post_date":"2018-12-03 16:02:06","post_date_gmt":"2018-12-03 15:02:06","post_content":"","post_title":"Peter M Clifton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"peter-m-clifton","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:06","post_modified_gmt":"2018-12-03 15:02:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/peter-m-clifton\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1740,"post_author":"0","post_date":"2018-12-03 16:02:07","post_date_gmt":"2018-12-03 15:02:07","post_content":"","post_title":"Michael Horowitz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"michael-horowitz","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:07","post_modified_gmt":"2018-12-03 15:02:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/michael-horowitz\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1741,"post_author":"0","post_date":"2018-12-03 16:02:07","post_date_gmt":"2018-12-03 15:02:07","post_content":"","post_title":"Christine Feinle-bisset","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christine-feinle-bisset","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:07","post_modified_gmt":"2018-12-03 15:02:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christine-feinle-bisset\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1719,"post_author":"0","post_date":"2018-12-03 16:01:56","post_date_gmt":"2018-12-03 15:01:56","post_content":"","post_title":"The American journal of clinical nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 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