{"id":61903,"date":"2013-10-01T00:00:00","date_gmt":"2018-12-04T08:05:00","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/"},"modified":"2018-12-04T09:05:00","modified_gmt":"2018-12-04T08:05:00","slug":"variation-of-serum-metabolites-related-to-habitual-diet-a","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/","title":{"rendered":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam."},"content":{"rendered":"

OBJECTIVE<\/strong>
\nSerum metabolites have been linked to higher risk of chronic diseases but determinants of serum metabolites are not clear. We aimed to investigate the association between habitual diet as a modifiable risk factor and relevant serum metabolites.<\/p>\n

METHODS<\/strong>
\nThis cross-sectional study comprised 2380 EPIC<\/span>-Potsdam participants. Intake of 45 food groups was assessed by food frequency questionnaire and concentrations of 127 serum metabolites were measured by targeted metabolomics. Reduced rank regression was used to find dietary patterns that explain the maximum variation of metabolites.<\/p>\n

RESULTS<\/strong>
\nIn the multivariable-adjusted model, the proportion of explained variation by habitual diet was ranked as follows: acyl-alkyl-phosphatidylcholines (5.7%), sphingomyelins (5.1%), diacyl-phosphatidylcholines (4.4%), lyso-phosphatidylcholines (4.1%), acylcarnitines (3.5%), amino acids (2.2%) and hexose (1.6%). A pattern with high intake of butter and low intake of margarine was related to acylcarnitines, acyl-alkyl-phosphatidylcholines, lyso-phosphatidylcholines and hydroxy-sphingomyelins, particularly with saturated and monounsaturated fatty acid side chains. A pattern with high intake of red meat and fish and low intake of whole-grain bread and tea was related to hexose and phosphatidylcholines. A pattern consisting of high intake of potatoes, dairy products and cornflakes particularly explained methionine and branched chain amino acids. Dietary patterns related to type 2 diabetes-relevant metabolites included high intake of red meat and low intake of whole-grain bread, tea, coffee, cake and cookies, canned fruits and fish.<\/p>\n

CONCLUSIONS<\/strong>
\nDietary patterns characterized by intakes of red meat, whole-grain bread, tea and coffee were linked to relevant metabolites and could be potential targets for chronic disease prevention.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-61903","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.","annee":"2013","mois":"10","numero":"67:10","page":"1100-1108","auteurs":[{"ID":1330,"post_author":"0","post_date":"2018-12-03 15:58:24","post_date_gmt":"2018-12-03 14:58:24","post_content":"","post_title":"Heiner Boeing","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"heiner-boeing","to_ping":"","pinged":"","post_modified":"2018-12-03 15:58:24","post_modified_gmt":"2018-12-03 14:58:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/heiner-boeing\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":41256,"post_author":"0","post_date":"2018-12-04 02:29:36","post_date_gmt":"2018-12-04 01:29:36","post_content":"","post_title":"A Floegel","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"a-floegel","to_ping":"","pinged":"","post_modified":"2018-12-04 02:29:36","post_modified_gmt":"2018-12-04 01:29:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/a-floegel\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1571,"post_author":"0","post_date":"2018-12-03 16:00:37","post_date_gmt":"2018-12-03 15:00:37","post_content":"","post_title":"A Von Ruesten","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"a-von-ruesten","to_ping":"","pinged":"","post_modified":"2018-12-03 16:00:37","post_modified_gmt":"2018-12-03 15:00:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/a-von-ruesten\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46692,"post_author":"0","post_date":"2018-12-04 04:05:19","post_date_gmt":"2018-12-04 03:05:19","post_content":"","post_title":"D Drogan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"d-drogan","to_ping":"","pinged":"","post_modified":"2018-12-04 04:05:19","post_modified_gmt":"2018-12-04 03:05:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/d-drogan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61901,"post_author":"0","post_date":"2018-12-04 09:04:58","post_date_gmt":"2018-12-04 08:04:58","post_content":"","post_title":"C Prehn","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"c-prehn","to_ping":"","pinged":"","post_modified":"2018-12-04 09:04:58","post_modified_gmt":"2018-12-04 08:04:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/c-prehn\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61902,"post_author":"0","post_date":"2018-12-04 09:04:59","post_date_gmt":"2018-12-04 08:04:59","post_content":"","post_title":"J Adamski","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"j-adamski","to_ping":"","pinged":"","post_modified":"2018-12-04 09:04:59","post_modified_gmt":"2018-12-04 08:04:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/j-adamski\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25313,"post_author":"0","post_date":"2018-12-03 22:16:45","post_date_gmt":"2018-12-03 21:16:45","post_content":"","post_title":"Tobias Pischon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tobias-pischon","to_ping":"","pinged":"","post_modified":"2018-12-03 22:16:45","post_modified_gmt":"2018-12-03 21:16:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tobias-pischon\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3356,"post_author":"0","post_date":"2018-12-03 17:04:46","post_date_gmt":"2018-12-03 16:04:46","post_content":"","post_title":"Matthias B Schulze","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"matthias-b-schulze","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:46","post_modified_gmt":"2018-12-03 16:04:46","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/matthias-b-schulze\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1262,"post_author":"0","post_date":"2018-12-03 15:57:47","post_date_gmt":"2018-12-03 14:57:47","post_content":"","post_title":"European journal of clinical nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:47","post_modified_gmt":"2018-12-03 14:57:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1732,"post_author":"0","post_date":"2018-12-03 16:02:02","post_date_gmt":"2018-12-03 15:02:02","post_content":"","post_title":"Eur J Clin Nutr.","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"eur-j-clin-nutr","to_ping":"","pinged":"","post_modified":"2018-12-03 16:02:02","post_modified_gmt":"2018-12-03 15:02:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/eur-j-clin-nutr\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nVariation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel<\/title>\n<meta name=\"description\" content=\"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam.\" \/>\n<meta property=\"og:description\" content=\"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/\",\"name\":\"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T08:05:00+00:00\",\"dateModified\":\"2018-12-04T08:05:00+00:00\",\"description\":\"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel","description":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam.","og_description":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/","name":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T08:05:00+00:00","dateModified":"2018-12-04T08:05:00+00:00","description":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/variation-of-serum-metabolites-related-to-habitual-diet-a\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/61903"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=61903"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=61903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}