{"id":61386,"date":"2013-09-01T00:00:00","date_gmt":"2018-12-04T07:56:13","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fat-diet-and-skin-cancer-risk-the-women-s-health-initiative-2\/"},"modified":"2018-12-04T08:56:13","modified_gmt":"2018-12-04T07:56:13","slug":"low-fat-diet-and-skin-cancer-risk-the-women-s-health-initiative-2","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/low-fat-diet-and-skin-cancer-risk-the-women-s-health-initiative-2\/","title":{"rendered":"Low-fat diet and skin cancer risk: the women’s health initiative randomized controlled dietary modification trial."},"content":{"rendered":"

BACKGROUND<\/strong>
\nLarge cohort studies have reported no relationship between dietary fat and nonmelanoma skin cancer (NMSC), although a low-fat diet intervention reduced NMSC risk in a small clinical trial. In animal studies, skin tumor development has been reduced by low-fat diet. We evaluated the effect of a low-fat dietary pattern on NMSC and melanoma in the Women's Health Initiative Dietary Modification trial.<\/p>\n

METHODS<\/strong>
\nPostmenopausal women aged 50 to 79 years (n = 48,835) were randomly assigned to the low-fat dietary pattern intervention (n = 19,541) or comparison group (n = 29,294). The intervention goals included decreasing fat intake to 20% or less of calories, increasing vegetable and fruit intake, and increasing grain intake. Self-reported incident NMSC (n = 4,907) and physician-adjudicated incident melanoma (n = 279) were ascertained every 6 months.<\/p>\n

RESULTS<\/strong>
\nOver 8.1 years of follow-up, the low-fat diet intervention did not affect overall incidence of NMSC [HR 0.98; 95% confidence interval (CI), 0.92-1.04] or melanoma (HR, 1.04; 95% CI, 0.82-1.32). In subgroup analyses of melanoma risk, baseline fat intake interacted significantly with group assignment (Pinteraction = 0.006). Among women with higher baseline fat intake, the dietary intervention significantly increased risk (HR, 1.48; 95% CI, 1.06-2.07), whereas, among women with lower baseline fat intake, the intervention tended to reduce melanoma risk (HR, 0.72; 95% CI, 0.50-1.02).<\/p>\n

CONCLUSIONS<\/strong>
\nIn this large randomized trial, a low-fat dietary pattern did not affect overall incidence of NMSC or melanoma.<\/p>\n

CONCLUSIONS<\/strong>
\nA low-fat diet does not reduce incidence of NMSC, but an interaction between baseline fat intake and dietary intervention on melanoma risk warrants further investigation.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-61386","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Stanford School of Medicine, Stanford University, Stanford, USA.","annee":"2013","mois":"9","numero":"22:9","page":"1509-1819","auteurs":[{"ID":25369,"post_author":"0","post_date":"2018-12-03 22:18:15","post_date_gmt":"2018-12-03 21:18:15","post_content":"","post_title":"James R Marshall","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"james-r-marshall","to_ping":"","pinged":"","post_modified":"2018-12-03 22:18:15","post_modified_gmt":"2018-12-03 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