{"id":61377,"date":"2014-01-01T00:00:00","date_gmt":"2018-12-04T07:56:00","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gastroesophageal-reflux-does-not-alter-effects-of-body-mass\/"},"modified":"2018-12-04T08:56:00","modified_gmt":"2018-12-04T07:56:00","slug":"gastroesophageal-reflux-does-not-alter-effects-of-body-mass","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/gastroesophageal-reflux-does-not-alter-effects-of-body-mass\/","title":{"rendered":"Gastroesophageal reflux does not alter effects of body mass index on risk of esophageal adenocarcinoma."},"content":{"rendered":"<p><strong>OBJECTIVE<\/strong><br \/>\nA history of high body mass index (BMI) is associated strongly with a risk of esophageal adenocarcinoma (EAC). We investigated whether gastroesophageal reflux is involved in this association.<\/p>\n<p><strong>METHODS<\/strong><br \/>\nWe analyzed data from a population-based Swedish nationwide study of patients with a new diagnosis of EAC (n&nbsp;= 189) or gastroesophageal junction adenocarcinoma (n&nbsp;= 262), and matched controls (n&nbsp;= 816), from 1995 through 1997. Our analysis included data on BMI 20&nbsp;years before study inclusion; maximum adult BMI; frequency, severity, and duration of gastroesophageal reflux symptoms; tumor features; and covariates (sex, age, smoking, alcohol, fruit and vegetable intake, and socioeconomic status). We conducted stratified analyses and synergy tests, adjusting for covariates.<\/p>\n<p><strong>RESULTS<\/strong><br \/>\nOdds ratios (ORs) for EAC among subjects with a BMI of 25 or higher 20 years before inclusion, compared with those with a BMI less than 25, did not differ significantly, without or with adjustment for gastroesophageal reflux frequency (OR, 3.1; 95% confidence interval [CI], 2.2-4.4; and OR, 3.3; 95% CI, 2.2-4.8, respectively), severity (OR, 3.3; 95% CI, 2.2-4.8), or duration (OR, 3.2; 95% CI, 2.2-4.7). However, there were interactions between BMI and categories of gastroesophageal reflux. BMI appeared to have the largest effect on gastroesophageal reflux frequency (synergy index, 8.9; 95% CI, 2.3-34.1 for maximum BMI; and gastroesophageal reflux &gt;3 times\/wk).<\/p>\n<p><strong>CONCLUSIONS<\/strong><br \/>\nBased on a population-based study, the association between BMI and EAC does not appear to be affected by symptomatic gastroesophageal reflux, although there appears to be synergy between BMI and reflux.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-61377","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Division of Cancer Studies, King's College London, London, United Kingdom. Electronic address: jesper.lagergren@ki.se.","annee":"2014","mois":"1","numero":"12:1","page":"45-51","auteurs":[{"ID":30647,"post_author":"0","post_date":"2018-12-03 23:34:36","post_date_gmt":"2018-12-03 22:34:36","post_content":"","post_title":"Jesper Lagergren","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jesper-lagergren","to_ping":"","pinged":"","post_modified":"2018-12-03 23:34:36","post_modified_gmt":"2018-12-03 22:34:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jesper-lagergren\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61376,"post_author":"0","post_date":"2018-12-04 08:55:59","post_date_gmt":"2018-12-04 07:55:59","post_content":"","post_title":"Fredrik Mattsson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fredrik-mattsson","to_ping":"","pinged":"","post_modified":"2018-12-04 08:55:59","post_modified_gmt":"2018-12-04 07:55:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fredrik-mattsson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57506,"post_author":"0","post_date":"2018-12-04 07:40:23","post_date_gmt":"2018-12-04 06:40:23","post_content":"","post_title":"Olof Nyr&eacute;n","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"olof-nyrn","to_ping":"","pinged":"","post_modified":"2018-12-04 07:40:23","post_modified_gmt":"2018-12-04 06:40:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/olof-nyrn\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":18354,"post_author":"0","post_date":"2018-12-03 20:04:11","post_date_gmt":"2018-12-03 19:04:11","post_content":"","post_title":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"clinical-gastroenterology-and-hepatology-the-official-clinical-practice-journal-of-the-american-gastroenterological-association","to_ping":"","pinged":"","post_modified":"2018-12-03 20:04:11","post_modified_gmt":"2018-12-03 19:04:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/clinical-gastroenterology-and-hepatology-the-official-clinical-practice-journal-of-the-american-gastroenterological-association\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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