{"id":61294,"date":"2013-11-01T00:00:00","date_gmt":"2018-12-04T07:54:26","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-bioactive-rich-extracts-of-pomegranate-persimmon\/"},"modified":"2018-12-04T08:54:26","modified_gmt":"2018-12-04T07:54:26","slug":"effects-of-bioactive-rich-extracts-of-pomegranate-persimmon","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effects-of-bioactive-rich-extracts-of-pomegranate-persimmon\/","title":{"rendered":"Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation."},"content":{"rendered":"

BACKGROUND<\/strong>
\nThe beneficial effect of fruit- and vegetable-rich diets on cardiovascular health is partly attributed to the effect of their bioactive compounds on platelet function. The aim of this study was to investigate the effects of bioactive-rich plant extracts and isolated bioactive metabolites on platelet function. Blood samples from healthy subjects (n = 4) and subjects with metabolic syndrome (n = 4) were treated with six extracts of bioactive-rich plants consumed as traditional foods in the Black Sea region, or with human metabolites of the bioactives quercetin and sulforaphane. Markers of arachidonic acid induced platelet activation and platelet-leucocyte aggregation were assessed using flow cytometry.<\/p>\n

RESULTS<\/strong>
\nIn subjects with metabolic syndrome, kale extract significantly inhibited agonist induced P-selectin expression (P = 0.004). Sulforaphane-cysteine-glycine, a human plasma metabolite of the related glucosinolate, glucoraphanin, significantly inhibited P-selectin and GPIIb-IIIa expression (P = 0.020 and 0.024, respectively) and platelet-neutrophil aggregation (P = 0.027). Additionally, pomegranate extract significantly inhibited GPIIb-IIIa expression (P = 0.046) in subjects with metabolic syndrome. In healthy subjects only dill extract significantly inhibited agonist induced P-selectin expression (P = 0.025).<\/p>\n

CONCLUSIONS<\/strong>
\nThese data show that bioactive-rich extracts of kale and pomegranate that are consumed as traditional plant foods of Black Sea area countries were effective in modulating platelet function.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-61294","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Institute for Medical Research, University of Belgrade, Belgrade, Serbia.","annee":"2013","mois":"11","numero":"93:14","page":"3581-3587","auteurs":[{"ID":61284,"post_author":"0","post_date":"2018-12-04 08:54:19","post_date_gmt":"2018-12-04 07:54:19","post_content":"","post_title":"Nevena Kardum","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nevena-kardum","to_ping":"","pinged":"","post_modified":"2018-12-04 08:54:19","post_modified_gmt":"2018-12-04 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07:54:25","post_content":"","post_title":"Tatjana Srdic-rajic","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tatjana-srdic-rajic","to_ping":"","pinged":"","post_modified":"2018-12-04 08:54:25","post_modified_gmt":"2018-12-04 07:54:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tatjana-srdic-rajic\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61293,"post_author":"0","post_date":"2018-12-04 08:54:25","post_date_gmt":"2018-12-04 07:54:25","post_content":"","post_title":"Vesna Aleksic-velickovic","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"vesna-aleksic-velickovic","to_ping":"","pinged":"","post_modified":"2018-12-04 08:54:25","post_modified_gmt":"2018-12-04 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