{"id":61156,"date":"2014-01-01T00:00:00","date_gmt":"2018-12-04T07:52:06","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-randomised-controlled-trial-of-increasing-fruit-and-vegetable\/"},"modified":"2018-12-04T08:52:06","modified_gmt":"2018-12-04T07:52:06","slug":"a-randomised-controlled-trial-of-increasing-fruit-and-vegetable","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-randomised-controlled-trial-of-increasing-fruit-and-vegetable\/","title":{"rendered":"A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>BACKGROUND<\/strong><br \/>\nHigh density lipoproteins (HDL) have many cardioprotective roles; however, in subjects with type 2 diabetes (T2D) these cardioprotective properties are diminished. Conversely, increased fruit and vegetable (F&amp;V) intake may reduce cardiovascular disease risk, although direct trial evidence of a mechanism by which this occurs in subjects with T2D is lacking. Therefore, the aim of this study was to examine if increased F&amp;V consumption influenced the carotenoid content and enzymes associated with the antioxidant properties of HDL in subjects with T2D.<\/p>\n<p style=\"text-align: justify\"><strong>METHODS<\/strong><br \/>\nEighty obese subjects with T2D were randomised to a 1- or &gt;=6-portion\/day F&amp;V diet for 8-weeks. Fasting serum was collected pre- and post-intervention. HDL was subfractionated into HDL2 and HDL3 by rapid ultracentrifugation. Carotenoids were measured in serum, HDL2 and HDL3 by high performance liquid chromatography. The activity of paraoxonase-1 (PON-1) was measured in serum, HDL2 and HDL3 by a spectrophotometric assay, while the activity of lecithin cholesterol acyltransferase (LCAT) was measured in serum, HDL2 and HDL3 by a fluorometric assay.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS<\/strong><br \/>\nIn the &gt;=6- vs. 1-portion post-intervention comparisons, carotenoids increased in serum, HDL2 and particularly HDL3, (alpha-carotene, p = 0.008; beta-cryptoxanthin, p = 0.042; lutein, p = 0.012; lycopene, p = 0.016), as did the activities of PON-1 and LCAT in HDL3 (p = 0.006 and 0.044, respectively).<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS<\/strong><br \/>\nTo our knowledge, this is the first study in subjects with T2D to demonstrate that increased F&amp;V intake augmented the carotenoid content and influenced enzymes associated with the antioxidant properties of HDL. We suggest that these changes would enhance the cardioprotective properties of this lipoprotein.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-61156","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"","annee":"2014","mois":"1","numero":"13:1","page":"16","auteurs":[{"ID":6702,"post_author":"0","post_date":"2018-12-03 17:40:59","post_date_gmt":"2018-12-03 16:40:59","post_content":"","post_title":"Jayne V Woodside","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jayne-v-woodside","to_ping":"","pinged":"","post_modified":"2018-12-03 17:40:59","post_modified_gmt":"2018-12-03 16:40:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jayne-v-woodside\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":6952,"post_author":"0","post_date":"2018-12-03 17:43:44","post_date_gmt":"2018-12-03 16:43:44","post_content":"","post_title":"Ian S Young","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ian-s-young","to_ping":"","pinged":"","post_modified":"2018-12-03 17:43:44","post_modified_gmt":"2018-12-03 16:43:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ian-s-young\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61155,"post_author":"0","post_date":"2018-12-04 08:52:04","post_date_gmt":"2018-12-04 07:52:04","post_content":"","post_title":"Jane-ann Daniels","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jane-ann-daniels","to_ping":"","pinged":"","post_modified":"2018-12-04 08:52:04","post_modified_gmt":"2018-12-04 07:52:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jane-ann-daniels\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9423,"post_author":"0","post_date":"2018-12-03 18:11:00","post_date_gmt":"2018-12-03 17:11:00","post_content":"","post_title":"Ciara Mulligan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ciara-mulligan","to_ping":"","pinged":"","post_modified":"2018-12-03 18:11:00","post_modified_gmt":"2018-12-03 17:11:00","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ciara-mulligan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":9428,"post_author":"0","post_date":"2018-12-03 18:11:02","post_date_gmt":"2018-12-03 17:11:02","post_content":"","post_title":"David R McCance","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"david-r-mccance","to_ping":"","pinged":"","post_modified":"2018-12-03 18:11:02","post_modified_gmt":"2018-12-03 17:11:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/david-r-mccance\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":26772,"post_author":"0","post_date":"2018-12-03 22:43:44","post_date_gmt":"2018-12-03 21:43:44","post_content":"","post_title":"Christopher C Patterson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christopher-c-patterson","to_ping":"","pinged":"","post_modified":"2018-12-03 22:43:44","post_modified_gmt":"2018-12-03 21:43:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christopher-c-patterson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":26084,"post_author":"0","post_date":"2018-12-03 22:32:38","post_date_gmt":"2018-12-03 21:32:38","post_content":"","post_title":"Jane Mceneny","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jane-mceneny","to_ping":"","pinged":"","post_modified":"2018-12-03 22:32:38","post_modified_gmt":"2018-12-03 21:32:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jane-mceneny\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":4017,"post_author":"0","post_date":"2018-12-03 17:11:35","post_date_gmt":"2018-12-03 16:11:35","post_content":"","post_title":"Cardiovascular diabetology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cardiovascular-diabetology","to_ping":"","pinged":"","post_modified":"2018-12-03 17:11:35","post_modified_gmt":"2018-12-03 16:11:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cardiovascular-diabetology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes. - Aprifel<\/title>\n<meta name=\"description\" content=\"A randomised controlled trial 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