{"id":61022,"date":"2013-12-01T00:00:00","date_gmt":"2018-12-04T07:49:43","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/"},"modified":"2018-12-04T08:49:43","modified_gmt":"2018-12-04T07:49:43","slug":"risk-factors-for-exudative-age-related-macular-degeneration","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/","title":{"rendered":"Risk factors for exudative age-related macular degeneration in a large French case-control study."},"content":{"rendered":"<p><strong>PURPOSE: <\/strong>The purpose of the CAP (Creteil AMD PHRC-funded) Study was to analyze risk factors of exudative age-related macular degeneration (AMD) in a large French case-control population.<\/p>\n<p><strong>METHODS: <\/strong>One thousand and twenty-four patients with exudative AMD and 275 controls were recruited. Information about lifestyle, medical history, and dietary intake were collected. Associations of risk factors were estimated using logistic regression.<\/p>\n<p><strong>RESULTS: <\/strong>After multivariate adjustment, CFH Y402H and ARMS2 A69S polymorphisms were associated with very high risk for exudative AMD (OR&thinsp;=&thinsp;6.21 and OR&thinsp;=&thinsp;11.7, respectively, p&thinsp;&lt;&thinsp;0.0001). Risk for exudative AMD was increased in current smokers (OR&thinsp;=&thinsp;3.79, p&thinsp;=&thinsp;0.0003) and former smokers having quitted since less than 20 years ago (OR&thinsp;=&thinsp;2.30, p&thinsp;=&thinsp;0.002), but not in former smokers having quitted since 20 years or more ago (OR&thinsp;=&thinsp;0.81, p&thinsp;=&thinsp;0.43). Heavy smokers (at least 25 pack-years) were particularly at risk (OR&thinsp;=&thinsp;3.61, p&thinsp;&lt;&thinsp;0.0001). Use of cooking oils rich in omega 3 fatty acids was significantly associated with a reduced risk of exudative AMD (OR&thinsp;=&thinsp;0.55, 95 % CI: 0.36-0.84, p&thinsp;=&thinsp;0.006), as well as a high consumption of fruits (OR&thinsp;=&thinsp;0.60, 95 % CI: 0.37-0.98, p&thinsp;=&thinsp;0.04), but not the consumption of fish, vegetables or oils rich in omega 6. High waist circumference was associated with increased risk for exudative AMD (OR&thinsp;=&thinsp;2.53, p&thinsp;&lt;&thinsp;0.0001), but not hypercholesterolemia, hypertension, or body mass index.<\/p>\n<p><strong>CONCLUSIONS: <\/strong>The CAP Study confirms major genetic risk factors for exudative AMD. It further documents the high risk in heavy smokers and the long persistence of risk after smoking cessation, and the associations with waist circumference and fruit consumption. Furthermore, we observed an inverse correlation between AMD and cooking oils harboring a beneficial omega-3 fatty acid profile.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-61022","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Ophthalmology, Hopital Intercommunal de Creteil, University Paris Est Creteil, Creteil, France.","annee":"2013","mois":"12","numero":"","page":"","auteurs":[{"ID":61015,"post_author":"0","post_date":"2018-12-04 08:49:39","post_date_gmt":"2018-12-04 07:49:39","post_content":"","post_title":"Jennyfer Zerbib","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jennyfer-zerbib","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:39","post_modified_gmt":"2018-12-04 07:49:39","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jennyfer-zerbib\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2176,"post_author":"0","post_date":"2018-12-03 16:53:07","post_date_gmt":"2018-12-03 15:53:07","post_content":"","post_title":"C\u00e9cile Delcourt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cecile-delcourt","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:07","post_modified_gmt":"2018-12-03 15:53:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/cecile-delcourt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61016,"post_author":"0","post_date":"2018-12-04 08:49:40","post_date_gmt":"2018-12-04 07:49:40","post_content":"","post_title":"Nathalie Puche","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nathalie-puche","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:40","post_modified_gmt":"2018-12-04 07:49:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nathalie-puche\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61017,"post_author":"0","post_date":"2018-12-04 08:49:40","post_date_gmt":"2018-12-04 07:49:40","post_content":"","post_title":"Giuseppe Querques","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"giuseppe-querques","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:40","post_modified_gmt":"2018-12-04 07:49:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/giuseppe-querques\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":37407,"post_author":"0","post_date":"2018-12-04 01:16:15","post_date_gmt":"2018-12-04 00:16:15","post_content":"","post_title":"Salomon Yves Cohen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"salomon-yves-cohen","to_ping":"","pinged":"","post_modified":"2018-12-04 01:16:15","post_modified_gmt":"2018-12-04 00:16:15","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/salomon-yves-cohen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61018,"post_author":"0","post_date":"2018-12-04 08:49:41","post_date_gmt":"2018-12-04 07:49:41","post_content":"","post_title":"Jos\u00e9 Sahel","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jose-sahel","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:41","post_modified_gmt":"2018-12-04 07:49:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jose-sahel\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2177,"post_author":"0","post_date":"2018-12-03 16:53:07","post_date_gmt":"2018-12-03 15:53:07","post_content":"","post_title":"Jean-Fran\u00e7ois Korobelnik","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jean-francois-korobelnik","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:07","post_modified_gmt":"2018-12-03 15:53:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jean-francois-korobelnik\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61019,"post_author":"0","post_date":"2018-12-04 08:49:42","post_date_gmt":"2018-12-04 07:49:42","post_content":"","post_title":"M\u00e9lanie Le Goff","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"melanie-le-goff","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:42","post_modified_gmt":"2018-12-04 07:49:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/melanie-le-goff\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":61020,"post_author":"0","post_date":"2018-12-04 08:49:42","post_date_gmt":"2018-12-04 07:49:42","post_content":"","post_title":"Eric H Souied","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"eric-h-souied","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:42","post_modified_gmt":"2018-12-04 07:49:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/eric-h-souied\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":61021,"post_author":"0","post_date":"2018-12-04 08:49:43","post_date_gmt":"2018-12-04 07:49:43","post_content":"","post_title":"Graefe's archive for clinical and experimental ophthalmology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"graefes-archive-for-clinical-and-experimental-ophthalmology","to_ping":"","pinged":"","post_modified":"2018-12-04 08:49:43","post_modified_gmt":"2018-12-04 07:49:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/graefes-archive-for-clinical-and-experimental-ophthalmology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel<\/title>\n<meta name=\"description\" content=\"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Risk factors for exudative age-related macular degeneration in a large French case-control study.\" \/>\n<meta property=\"og:description\" content=\"Risk factors for exudative age-related macular degeneration in a large French case-control study.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/\",\"name\":\"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T07:49:43+00:00\",\"dateModified\":\"2018-12-04T07:49:43+00:00\",\"description\":\"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Risk factors for exudative age-related macular degeneration in a large French case-control study.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel","description":"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Risk factors for exudative age-related macular degeneration in a large French case-control study.","og_description":"Risk factors for exudative age-related macular degeneration in a large French case-control study.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/","name":"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T07:49:43+00:00","dateModified":"2018-12-04T07:49:43+00:00","description":"Risk factors for exudative age-related macular degeneration in a large French case-control study. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/risk-factors-for-exudative-age-related-macular-degeneration\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Risk factors for exudative age-related macular degeneration in a large French case-control study."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/61022"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=61022"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=61022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}