{"id":60913,"date":"2014-03-01T00:00:00","date_gmt":"2018-12-04T07:48:05","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/flavonoid-rich-fruit-and-vegetables-improve-microvascular\/"},"modified":"2018-12-04T08:48:05","modified_gmt":"2018-12-04T07:48:05","slug":"flavonoid-rich-fruit-and-vegetables-improve-microvascular","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/flavonoid-rich-fruit-and-vegetables-improve-microvascular\/","title":{"rendered":"Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease–FLAVURS: a randomized controlled trial."},"content":{"rendered":"

BACKGROUND<\/strong>
\nObserved associations between increased fruit and vegetable (F&V) consumption, particularly those F&Vs that are rich in flavonoids, and vascular health improvements require confirmation in adequately powered randomized controlled trials.<\/p>\n

OBJECTIVE<\/strong>
\nThis study was designed to measure the dose-response relation between high-flavonoid (HF), low-flavonoid (LF), and habitual F&V intakes and vascular function and other cardiovascular disease (CVD) risk indicators.<\/p>\n

METHODS<\/strong>
\nA single-blind, dose-dependent, parallel randomized controlled dietary intervention study was conducted. Male and female low-F&V consumers who had a ≥ 1.5-fold increased risk of CVD (n = 174) were randomly assigned to receive an HF F&V, an LF F&V, or a habitual diet, with HF and LF F&V amounts sequentially increasing by 2, 4, and 6 (+2, +4, and +6) portions\/d every 6 wk over habitual intakes. Microvascular reactivity (laser Doppler imaging with iontophoresis), arterial stiffness [pulse wave velocity, pulse wave analysis (PWA)], 24-h ambulatory blood pressure, and biomarkers of nitric oxide (NO), vascular function, and inflammation were determined at baseline and at 6, 12, and 18 wk.<\/p>\n

RESULTS<\/strong>
\nIn men, the HF F&V diet increased endothelium-dependent microvascular reactivity (P = 0.017) with +2 portions\/d (at 6 wk) and reduced C-reactive protein (P = 0.001), E-selectin (P = 0.0005), and vascular cell adhesion molecule (P = 0.0468) with +4 portions\/d (at 12 wk). HF F&Vs increased plasma NO (P = 0.0243) with +4 portions\/d (at 12 wk) in the group as a whole. An increase in F&Vs, regardless of flavonoid content in the groups as a whole, mitigated increases in vascular stiffness measured by PWA (P = 0.0065) and reductions in NO (P = 0.0299) in the control group.<\/p>\n

CONCLUSIONS<\/strong>
\nThese data support recommendations to increase F&V intake to ≥ 6 portions daily, with additional benefit from F&Vs that are rich in flavonoids, particularly in men with an increased risk of CVD.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-60913","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Hugh Sinclair Unit of Human Nutrition (ALM, TWG, MFC, DSA, YJ, AV, JPES, OBK, KMT, A-MM, MHG, and JAL), and the Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Sciences (ALM and JAL), University of Reading, Reading, Berkshire, United Kingdom.","annee":"2014","mois":"3","numero":"99:3","page":"479-489","auteurs":[{"ID":5595,"post_author":"0","post_date":"2018-12-03 17:29:33","post_date_gmt":"2018-12-03 16:29:33","post_content":"","post_title":"Anna L 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Alimbetov","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dauren-s-alimbetov","to_ping":"","pinged":"","post_modified":"2018-12-04 08:48:02","post_modified_gmt":"2018-12-04 07:48:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dauren-s-alimbetov\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30626,"post_author":"0","post_date":"2018-12-03 23:34:21","post_date_gmt":"2018-12-03 22:34:21","post_content":"","post_title":"Yannan Jin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yannan-jin","to_ping":"","pinged":"","post_modified":"2018-12-03 23:34:21","post_modified_gmt":"2018-12-03 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Spencer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jeremy-pe-spencer","to_ping":"","pinged":"","post_modified":"2018-12-03 19:41:02","post_modified_gmt":"2018-12-03 18:41:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jeremy-pe-spencer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4799,"post_author":"0","post_date":"2018-12-03 17:21:05","post_date_gmt":"2018-12-03 16:21:05","post_content":"","post_title":"Orla B Kennedy","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"orla-b-kennedy","to_ping":"","pinged":"","post_modified":"2018-12-03 17:21:05","post_modified_gmt":"2018-12-03 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Minihane","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"anne-marie-minihane","to_ping":"","pinged":"","post_modified":"2018-12-03 23:34:21","post_modified_gmt":"2018-12-03 22:34:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/anne-marie-minihane\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30628,"post_author":"0","post_date":"2018-12-03 23:34:22","post_date_gmt":"2018-12-03 22:34:22","post_content":"","post_title":"Michael H Gordon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"michael-h-gordon","to_ping":"","pinged":"","post_modified":"2018-12-03 23:34:22","post_modified_gmt":"2018-12-03 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American journal of clinical nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"the-american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:56","post_modified_gmt":"2018-12-03 15:01:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/the-american-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nFlavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease-FLAVURS: a randomized controlled trial. - Aprifel<\/title>\n<meta name=\"description\" content=\"Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease-FLAVURS: a randomized controlled trial. - Aprifel\" \/>\n<meta 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