{"id":60426,"date":"2013-09-01T00:00:00","date_gmt":"2018-12-04T07:39:44","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/infant-exposures-and-development-of-type-1-diabetes-mellitus\/"},"modified":"2018-12-04T08:39:44","modified_gmt":"2018-12-04T07:39:44","slug":"infant-exposures-and-development-of-type-1-diabetes-mellitus","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/infant-exposures-and-development-of-type-1-diabetes-mellitus\/","title":{"rendered":"Infant exposures and development of type 1 diabetes mellitus: The Diabetes Autoimmunity Study in the Young (DAISY)."},"content":{"rendered":"

IMPORTANCE<\/strong>
\nThe incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide, with the most rapid increase among children younger than 5 years of age.<\/p>\n

OBJECTIVE<\/strong>
\nTo examine the associations between perinatal and infant exposures, especially early infant diet, and the development of T1DM.<\/p>\n

DESIGN<\/strong>
\nThe Diabetes Autoimmunity Study in the Young (DAISY) is a longitudinal, observational study.<\/p>\n

SETTING<\/strong>
\nNewborn screening for human leukocyte antigen (HLA) was done at St. Joseph's Hospital in Denver, Colorado. First-degree relatives of individuals with T1DM were recruited from the Denver metropolitan area.<\/p>\n

PARTICIPANTS<\/strong>
\nA total of 1835 children at increased genetic risk for T1DM followed up from birth with complete prospective assessment of infant diet. Fifty-three children developed T1DM.<\/p>\n

EXPOSURES<\/strong>
\nEarly (<4 months of age) and late (≥6 months of age) first exposure to solid foods compared with first exposures at 4 to 5 months of age (referent).<\/p>\n

MAIN OUTCOME AND MEASURE<\/strong>
\nRisk for T1DM diagnosed by a physician.<\/p>\n

RESULTS<\/strong>
\nBoth early and late first exposure to any solid food predicted development of T1DM (hazard ratio [HR], 1.91; 95% CI, 1.04-3.51, and HR, 3.02; 95% CI, 1.26-7.24, respectively), adjusting for the HLA-DR genotype, first-degree relative with T1DM, maternal education, and delivery type. Specifically, early exposure to fruit and late exposure to rice\/oat predicted T1DM (HR, 2.23; 95% CI, 1.14-4.39, and HR, 2.88; 95% CI, 1.36-6.11, respectively), while breastfeeding at the time of introduction to wheat\/barley conferred protection (HR, 0.47; 95% CI, 0.26-0.86). Complicated vaginal delivery was also a predictor of T1DM (HR, 1.93; 95% CI, 1.03-3.61).<\/p>\n

CONCLUSIONS AND RELEVANCE<\/strong>
\nThese results suggest the safest age to introduce solid foods in children at increased genetic risk for T1DM is between 4 and 5 months of age. Breastfeeding while introducing new foods may reduce T1DM risk.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-60426","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Colorado School of Public Health, University of Colorado, Aurora.","annee":"2013","mois":"9","numero":"167:9","page":"808-815","auteurs":[{"ID":60422,"post_author":"0","post_date":"2018-12-04 08:39:41","post_date_gmt":"2018-12-04 07:39:41","post_content":"","post_title":"Brittni Frederiksen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"brittni-frederiksen","to_ping":"","pinged":"","post_modified":"2018-12-04 08:39:41","post_modified_gmt":"2018-12-04 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