{"id":60173,"date":"2013-11-01T00:00:00","date_gmt":"2018-12-04T07:35:07","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-reduces-the-adverse-effect-of-the-tcf7l2-rs7903146\/"},"modified":"2018-12-04T08:35:07","modified_gmt":"2018-12-04T07:35:07","slug":"mediterranean-diet-reduces-the-adverse-effect-of-the-tcf7l2-rs7903146","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-reduces-the-adverse-effect-of-the-tcf7l2-rs7903146\/","title":{"rendered":"Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population."},"content":{"rendered":"

OBJECTIVE<\/strong>
\nTranscription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet.<\/p>\n

RESEARCH DESIGN AND METHODS<\/strong>
\nA randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events.<\/p>\n

RESULTS<\/strong>
\nThe TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62-2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 ± 3.5 mg\/dL) than CC+CT (127.3 ± 3.2 mg\/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36-6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49-1.87]; P = 0.892 for TT compared with CC).<\/p>\n

CONCLUSIONS<\/strong>
\nOur novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-60173","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Corresponding author: Dolores Corella, dolores.corella@uv.es.","annee":"2013","mois":"11","numero":"36:11","page":"3803-3811","auteurs":[{"ID":1164,"post_author":"0","post_date":"2018-12-03 15:56:56","post_date_gmt":"2018-12-03 14:56:56","post_content":"","post_title":"Ram\u00f3n Estruch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ramon-estruch","to_ping":"","pinged":"","post_modified":"2018-12-03 15:56:56","post_modified_gmt":"2018-12-03 14:56:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ramon-estruch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1549,"post_author":"0","post_date":"2018-12-03 16:00:25","post_date_gmt":"2018-12-03 15:00:25","post_content":"","post_title":"Miguel Angel Mart\u00ednez-Gonz\u00e1lez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miguel-angel-martinez-gonzalez","to_ping":"","pinged":"","post_modified":"2018-12-03 16:00:25","post_modified_gmt":"2018-12-03 15:00:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/miguel-angel-martinez-gonzalez\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":2139,"post_author":"0","post_date":"2018-12-03 16:52:45","post_date_gmt":"2018-12-03 15:52:45","post_content":"","post_title":"Lluis Serra-majem","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lluis-serra-majem","to_ping":"","pinged":"","post_modified":"2018-12-03 16:52:45","post_modified_gmt":"2018-12-03 15:52:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lluis-serra-majem\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":27322,"post_author":"0","post_date":"2018-12-03 22:51:18","post_date_gmt":"2018-12-03 21:51:18","post_content":"","post_title":"Dolores Corella D","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dolores-corella-d","to_ping":"","pinged":"","post_modified":"2018-12-03 22:51:18","post_modified_gmt":"2018-12-03 21:51:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dolores-corella-d\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4534,"post_author":"0","post_date":"2018-12-03 17:18:25","post_date_gmt":"2018-12-03 16:18:25","post_content":"","post_title":"Jordi Salas-Salvad\u00f3","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jordi-salas-salvado","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:25","post_modified_gmt":"2018-12-03 16:18:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jordi-salas-salvado\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4535,"post_author":"0","post_date":"2018-12-03 17:18:25","post_date_gmt":"2018-12-03 16:18:25","post_content":"","post_title":"Carolina Ortega-Azor\u00edn","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carolina-ortega-azorin","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:25","post_modified_gmt":"2018-12-03 16:18:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/carolina-ortega-azorin\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":7531,"post_author":"0","post_date":"2018-12-03 17:50:12","post_date_gmt":"2018-12-03 16:50:12","post_content":"","post_title":"Oscar Coltell","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"oscar-coltell","to_ping":"","pinged":"","post_modified":"2018-12-03 17:50:12","post_modified_gmt":"2018-12-03 16:50:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/oscar-coltell\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":60170,"post_author":"0","post_date":"2018-12-04 08:35:03","post_date_gmt":"2018-12-04 07:35:03","post_content":"","post_title":"Jos\u00e9 I. 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