{"id":60076,"date":"2014-02-01T00:00:00","date_gmt":"2018-12-04T07:33:32","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/modulation-of-plasma-antioxidant-levels-glutathione-s-transferase\/"},"modified":"2018-12-04T08:33:32","modified_gmt":"2018-12-04T07:33:32","slug":"modulation-of-plasma-antioxidant-levels-glutathione-s-transferase","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/modulation-of-plasma-antioxidant-levels-glutathione-s-transferase\/","title":{"rendered":"Modulation of plasma antioxidant levels, glutathione S-transferase activity and DNA damage in smokers following a single portion of broccoli: a pilot study."},"content":{"rendered":"

BACKGROUND<\/strong>
\nBroccoli is a rich source of bioactive compounds (i.e. glucosinolates, carotenoids, vitamin C and folate) that may exert an antioxidant effect and reduce oxidative damage. The objective of this pilot study was to investigate the effect of broccoli consumption on carotenoids, vitamin C and folate absorption, glutathione S-transferase (GST) activity, and oxidatively induced DNA damage in male smokers.<\/p>\n

METHODS<\/strong>
\nTen healthy subjects consumed a single portion of steamed broccoli (250 g) with cooked pasta. Blood was drawn at baseline and at 3, 6 and 24 h from consumption.<\/p>\n

RESULTS<\/strong>
\nBroccoli significantly (P≤ 0.01) increased plasma level of vitamin C and folate (+35% and 70%, respectively) at 3 h, and β-carotene (+8%) at 6 h. A modulation of GST activity occurred in plasma 6 h after broccoli consumption. A significant (P≤ 0.01) reduction of the levels of H2 O2 -induced DNA damage (-18%) was observed in blood mononuclear cells 24 h after broccoli intake in GSTM1 positive, but not in GSTM1 null subjects.<\/p>\n

CONCLUSION<\/strong>
\nOne portion of broccoli increased plasma antioxidant levels, modulated plasma GST activity and improved cell resistance against H2 O2 -induced DNA damage in healthy smokers. These results support the importance of consuming fruit and vegetable regularly.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-60076","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Universit\u00e0 degli Studi di Milano, DeFENS-Department of Food, Environmental and Nutritional Sciences, via Celoria 2, 20133, Milan, Italy.","annee":"2014","mois":"2","numero":"94:3","page":"522-528","auteurs":[{"ID":17351,"post_author":"0","post_date":"2018-12-03 19:50:18","post_date_gmt":"2018-12-03 18:50:18","post_content":"","post_title":"Patrizia Riso","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"patrizia-riso","to_ping":"","pinged":"","post_modified":"2018-12-03 19:50:18","post_modified_gmt":"2018-12-03 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