{"id":59736,"date":"2013-08-01T00:00:00","date_gmt":"2018-12-04T07:28:04","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-and-prostate-cancer-risk-and-mortality\/"},"modified":"2018-12-04T08:28:04","modified_gmt":"2018-12-04T07:28:04","slug":"mediterranean-diet-and-prostate-cancer-risk-and-mortality","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/mediterranean-diet-and-prostate-cancer-risk-and-mortality\/","title":{"rendered":"Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study."},"content":{"rendered":"

BACKGROUND<\/strong>
\nProstate cancer (PCa) mortality rates are lower in the Mediterranean countries compared with northern Europe. Although specific components of the Mediterranean diet (Med-Diet) may influence PCa risk, few studies have assessed the traditional Med-Diet pattern with the risk of incident advanced or lethal PCa or with disease progression among men diagnosed with nonmetastatic PCa.<\/p>\n

OBJECTIVE<\/strong>
\nTo determine whether the traditional Med-Diet pattern is associated with risk of incident advanced or lethal PCa and with PCa-specific and overall mortality among men with PCa.<\/p>\n

DESIGN, SETTING, AND PARTICIPANTS<\/strong>
\nWe prospectively followed 47 867 men in the Health Professionals Follow-up Study followed from 1986 to 2010. The case-only analysis included 4538 men diagnosed with nonmetastatic PCa, followed from diagnosis to lethal outcome or to January 2010.<\/p>\n

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS<\/strong>
\nWe used Cox proportional hazards models to examine traditional and alternative Med-Diet scores in relation to PCa incidence outcomes (advanced and lethal disease). In a case-only survival analysis, we examined postdiagnostic Med-Diet and risk of lethal (metastases or PCa death) and fatal PCa as well as overall mortality among men diagnosed with nonmetastatic disease.<\/p>\n

RESULTS AND LIMITATIONS<\/strong>
\nBetween 1986 and 2010, 6220 PCa cases were confirmed. The Med-Diet was not associated with risk of advanced or lethal PCa. In the case-only analysis, there was no association between the Med-Diet after diagnosis and risk of lethal or fatal PCa. However, there was a 22% lower risk of overall mortality (hazard ratio: 0.78; 95% confidence interval, 0.67-0.90; ptrend=0.0007) among men with greater adherence to the Med-Diet after PCa diagnosis. We found similar associations for the alternative score.<\/p>\n

CONCLUSIONS<\/strong>
\nA higher Med-Diet score was not associated with risk of advanced PCa or disease progression. Greater adherence to the Med-Diet after diagnosis of nonmetastatic PCa was associated with lower overall mortality.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-59736","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Urology, University of California, San Francisco, San Francisco, CA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. Electronic address: KenfieldS@urology.ucsf.edu.","annee":"2013","mois":"8","numero":"","page":"","auteurs":[{"ID":26627,"post_author":"0","post_date":"2018-12-03 22:41:11","post_date_gmt":"2018-12-03 21:41:11","post_content":"","post_title":"M J Stampfer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"m-j-stampfer","to_ping":"","pinged":"","post_modified":"2018-12-03 22:41:11","post_modified_gmt":"2018-12-03 21:41:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/m-j-stampfer\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8690,"post_author":"0","post_date":"2018-12-03 18:02:58","post_date_gmt":"2018-12-03 17:02:58","post_content":"","post_title":"Stacey A Kenfield","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stacey-a-kenfield","to_ping":"","pinged":"","post_modified":"2018-12-03 18:02:58","post_modified_gmt":"2018-12-03 17:02:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stacey-a-kenfield\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12260,"post_author":"0","post_date":"2018-12-03 18:44:34","post_date_gmt":"2018-12-03 17:44:34","post_content":"","post_title":"Edward L Giovannucci","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"edward-l-giovannucci","to_ping":"","pinged":"","post_modified":"2018-12-03 18:44:34","post_modified_gmt":"2018-12-03 17:44:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/edward-l-giovannucci\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":59734,"post_author":"0","post_date":"2018-12-04 08:28:03","post_date_gmt":"2018-12-04 07:28:03","post_content":"","post_title":"Natalie Dupre","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"natalie-dupre","to_ping":"","pinged":"","post_modified":"2018-12-04 08:28:03","post_modified_gmt":"2018-12-04 07:28:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/natalie-dupre\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":37978,"post_author":"0","post_date":"2018-12-04 01:27:50","post_date_gmt":"2018-12-04 00:27:50","post_content":"","post_title":"Erin L Richman","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"erin-l-richman","to_ping":"","pinged":"","post_modified":"2018-12-04 01:27:50","post_modified_gmt":"2018-12-04 00:27:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/erin-l-richman\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8691,"post_author":"0","post_date":"2018-12-03 18:02:59","post_date_gmt":"2018-12-03 17:02:59","post_content":"","post_title":"June M Chan","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"june-m-chan","to_ping":"","pinged":"","post_modified":"2018-12-03 18:02:59","post_modified_gmt":"2018-12-03 17:02:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/june-m-chan\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":52441,"post_author":"0","post_date":"2018-12-04 06:02:47","post_date_gmt":"2018-12-04 05:02:47","post_content":"","post_title":"European urology","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-urology","to_ping":"","pinged":"","post_modified":"2018-12-04 06:02:47","post_modified_gmt":"2018-12-04 05:02:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-urology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":59735,"post_author":"0","post_date":"2018-12-04 08:28:04","post_date_gmt":"2018-12-04 07:28:04","post_content":"","post_title":"Eur 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