{"id":59623,"date":"2014-02-01T00:00:00","date_gmt":"2018-12-04T07:25:39","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-the-mediterranean-diet-on-heart-failure-biomarkers\/"},"modified":"2018-12-04T08:25:39","modified_gmt":"2018-12-04T07:25:39","slug":"effect-of-the-mediterranean-diet-on-heart-failure-biomarkers","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-the-mediterranean-diet-on-heart-failure-biomarkers\/","title":{"rendered":"Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from the PREDIMED trial."},"content":{"rendered":"<p><strong>AIMS: <\/strong>Scarce data are available on the effect of the traditional Mediterranean diet (TMD) on heart failure biomarkers. We assessed the effect of TMD on biomarkers related to heart failure in a high cardiovascular disease risk population.<\/p>\n<p><strong>METHODS AND RESULTS: <\/strong>A total of 930 subjects at high cardiovascular risk (420 men and 510 women) were recruited in the framework of a multicentre, randomized, controlled, parallel-group clinical trial directed at testing the efficacy of the TMD on the primary prevention of cardiovascular disease (The PREDIMED Study). Participants were assigned to a low-fat diet (control, n = 310) or one of two TMDs [TMD + virgin olive oil (VOO) or TMD + nuts]. Depending on group assignment, participants received free provision of extra-virgin olive oil, mixed nuts, or small non-food gifts. After 1 year of intervention, both TMDs decreased plasma N-terminal pro-brain natriuretic peptide, with changes reaching significance vs. control group (P &lt; 0.05). Oxidized low-density lipoprotein decreased in both TMD groups (P &lt; 0.05), the decrease in TMD + VOO group reaching significance vs. changes in control group (P = 0.003). Changes in lipoprotein(a) after TMD + VOO were less than those in the control group (P = 0.046) in which an increase (P = 0.035) was observed. No changes were observed in urinary albumin or albumin\/creatinine ratio.<\/p>\n<p><strong>CONCLUSIONS: <\/strong>Individuals at high risk of cardiovascular disease (CVD) who improved their diet toward a TMD pattern reduced their N-terminal pro-brain natriuretic peptide compared with those assigned to a low-fat diet. The same was found for in vivo oxidized low-density lipoprotein and lipoprotein(a) plasma concentrations after the TMD + VOO diet. From our results TMD could be a useful tool to mitigate against risk factors for heart failure. From our results TMD could modify markers of heart failure towards a more protective mode.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-59623","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Cardiovascular Risk and Nutrition Research Group, Institut Hospital del Mar d'Investigacions Biom\u00e8diques (IMIM), Barcelona; CIBER de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Madrid.","annee":"2014","mois":"2","numero":"","page":"","auteurs":[{"ID":2210,"post_author":"0","post_date":"2018-12-03 16:53:24","post_date_gmt":"2018-12-03 15:53:24","post_content":"","post_title":"Montserrat F\u00edto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"montserrat-fito","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:24","post_modified_gmt":"2018-12-03 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D","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dolores-corella-d","to_ping":"","pinged":"","post_modified":"2018-12-03 22:51:18","post_modified_gmt":"2018-12-03 21:51:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dolores-corella-d\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4536,"post_author":"0","post_date":"2018-12-03 17:18:26","post_date_gmt":"2018-12-03 16:18:26","post_content":"","post_title":"Emilio Ros","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"emilio-ros","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:26","post_modified_gmt":"2018-12-03 16:18:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/emilio-ros\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23771,"post_author":"0","post_date":"2018-12-03 21:36:01","post_date_gmt":"2018-12-03 20:36:01","post_content":"","post_title":"Valentina Ruiz-Guti\u00e9rrez","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"valentina-ruiz-gutierrez","to_ping":"","pinged":"","post_modified":"2018-12-03 21:36:01","post_modified_gmt":"2018-12-03 20:36:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/valentina-ruiz-gutierrez\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":13462,"post_author":"0","post_date":"2018-12-03 18:58:29","post_date_gmt":"2018-12-03 17:58:29","post_content":"","post_title":"Miquel Fiol","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miquel-fiol","to_ping":"","pinged":"","post_modified":"2018-12-03 18:58:29","post_modified_gmt":"2018-12-03 17:58:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/miquel-fiol\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":51693,"post_author":"0","post_date":"2018-12-04 05:42:24","post_date_gmt":"2018-12-04 04:42:24","post_content":"","post_title":"Joan Vila","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"joan-vila","to_ping":"","pinged":"","post_modified":"2018-12-04 05:42:24","post_modified_gmt":"2018-12-04 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Torre","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rafael-de-la-torre","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:25","post_modified_gmt":"2018-12-03 17:09:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rafael-de-la-torre\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":23772,"post_author":"0","post_date":"2018-12-03 21:36:02","post_date_gmt":"2018-12-03 20:36:02","post_content":"","post_title":"Maria-Teresa Mitjavila","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"maria-teresa-mitjavila","to_ping":"","pinged":"","post_modified":"2018-12-03 21:36:02","post_modified_gmt":"2018-12-03 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16:18:30","post_content":"","post_title":"Fernando Ar\u00f3s","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fernando-aros","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:30","post_modified_gmt":"2018-12-03 16:18:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fernando-aros\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4546,"post_author":"0","post_date":"2018-12-03 17:18:31","post_date_gmt":"2018-12-03 16:18:31","post_content":"","post_title":"Miguel \u00c1ngel Mu\u00f1oz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miguel-angel-munoz","to_ping":"","pinged":"","post_modified":"2018-12-03 17:18:31","post_modified_gmt":"2018-12-03 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