{"id":59161,"date":"2014-03-01T00:00:00","date_gmt":"2018-12-04T07:17:38","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-relation-of-diet-with-paf-and-its-metabolic-enzymes-in-healthy\/"},"modified":"2018-12-04T08:17:38","modified_gmt":"2018-12-04T07:17:38","slug":"the-relation-of-diet-with-paf-and-its-metabolic-enzymes-in-healthy","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/the-relation-of-diet-with-paf-and-its-metabolic-enzymes-in-healthy\/","title":{"rendered":"The relation of diet with PAF and its metabolic enzymes in healthy volunteers."},"content":{"rendered":"<p style=\"text-align: justify\"><strong>PURPOSE<\/strong><br \/>\nPlatelet-activating factor (PAF), a potent inflammatory mediator, is implicated in atherosclerosis. Its key biosynthetic enzymes are lyso-PAF acetyltransferases (lyso-PAF-AT), responsible for PAF synthesis through the remodeling route and a specific CDP-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT), responsible for its de novo biosynthesis. PAF acetylhydrolase (PAF-AH) and its extracellular isoform lipoprotein-associated phospholipase A2 catabolize PAF. The impact of diet on PAF metabolism is ill-defined. The aim was to investigate associations between PAF, its enzymes and dietary factors.<\/p>\n<p style=\"text-align: justify\"><strong>METHODS<\/strong><br \/>\nOne-hundred and six (n&nbsp;=&nbsp;106) healthy volunteers were recruited. Food-frequency questionnaires, dietary recalls, lifestyle and biochemical variables were collected. Food groups, macronutrient intake, a priori (MedDietScore) and a posteriori defined food patterns with PCA analysis, dietary antioxidant capacity (DAC), glycemic index (GI) and glycemic load were assessed.<\/p>\n<p style=\"text-align: justify\"><strong>RESULTS<\/strong><br \/>\nPAF was inversely correlated with antioxidant-rich foods (herbal drinks and coffee), the DAC as well as a dietary pattern characterized by legumes, vegetables, poultry and fish (all Ps&nbsp;&lt;&nbsp;0.05). PAF was positively correlated to % fat intake. Lyso-PAF-AT was also negatively associated with healthy patterns (fruits, nuts and herbal drinks, and a pattern rich in olive oil and whole-wheat products), as well as the DAC and % monounsaturated fatty acids. PAF-CPT was negatively associated with GI and coffee intake and positively with dietary cholesterol. PAF-AH was negatively associated with coffee and positively associated with alcohol consumption (all Ps&nbsp;&lt;&nbsp;0.05).<\/p>\n<p style=\"text-align: justify\"><strong>CONCLUSIONS<\/strong><br \/>\nIn conclusion, the DAC and healthy dietary patterns were inversely associated with PAF or its biosynthetic enzymes, suggesting potential new mechanisms of the diet-disease associations.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-59161","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Nutrition-Dietetics, Harokopio University, 70 El. Venizelou Street, 17671, Athens, Greece.\r\nd.b.panagiotakos@usa.net\r\n","annee":"2014","mois":"3","numero":"","page":"","auteurs":[{"ID":59159,"post_author":"0","post_date":"2018-12-04 08:17:36","post_date_gmt":"2018-12-04 07:17:36","post_content":"","post_title":"P Detopoulou","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"p-detopoulou","to_ping":"","pinged":"","post_modified":"2018-12-04 08:17:36","post_modified_gmt":"2018-12-04 07:17:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/p-detopoulou\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3281,"post_author":"0","post_date":"2018-12-03 17:04:02","post_date_gmt":"2018-12-03 16:04:02","post_content":"","post_title":"Elizabeth Fragopoulou","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"elizabeth-fragopoulou","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:02","post_modified_gmt":"2018-12-03 16:04:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/elizabeth-fragopoulou\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3280,"post_author":"0","post_date":"2018-12-03 17:04:01","post_date_gmt":"2018-12-03 16:04:01","post_content":"","post_title":"Tzortzis Nomikos","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tzortzis-nomikos","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:01","post_modified_gmt":"2018-12-03 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Stamatakis","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"g-stamatakis","to_ping":"","pinged":"","post_modified":"2018-12-04 08:17:37","post_modified_gmt":"2018-12-04 07:17:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/g-stamatakis\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":26202,"post_author":"0","post_date":"2018-12-03 22:34:37","post_date_gmt":"2018-12-03 21:34:37","post_content":"","post_title":"D B Panagiotakos","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"d-b-panagiotakos","to_ping":"","pinged":"","post_modified":"2018-12-03 22:34:37","post_modified_gmt":"2018-12-03 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15:53:22","post_content":"","post_title":"European journal of nutrition","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"european-journal-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-03 16:53:22","post_modified_gmt":"2018-12-03 15:53:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/european-journal-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The relation of diet with PAF and its metabolic enzymes in healthy volunteers. - Aprifel<\/title>\n<meta name=\"description\" content=\"The relation of diet with PAF and its metabolic enzymes in healthy volunteers. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, 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