{"id":58468,"date":"1999-06-01T00:00:00","date_gmt":"2018-12-04T06:59:04","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/impairment-of-endothelial-functions-by-acute-hyperhomocysteinemia\/"},"modified":"2018-12-04T07:59:04","modified_gmt":"2018-12-04T06:59:04","slug":"impairment-of-endothelial-functions-by-acute-hyperhomocysteinemia","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/impairment-of-endothelial-functions-by-acute-hyperhomocysteinemia\/","title":{"rendered":"Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins"},"content":{"rendered":"<p>CONTEXT: Increased levels of homocysteine are associated with risk of cardiovascular disease. Homocysteine may cause this risk by impairing endothelial cell function.<\/p>\n<p>OBJECTIVE: To evaluate the effect of acute hyperhomocysteinemia with and without antioxidant vitamin pretreatment on cardiovascular risk factors and endothelial functions.<\/p>\n<p>DESIGN AND SETTING: Observer-blinded, randomized crossover study conducted at a university hospital in Italy.<\/p>\n<p>SUBJECTS: Twenty healthy hospital staff volunteers (10 men, 10 women) aged 25 to 45 years.<\/p>\n<p>INTERVENTIONS: Subjects were given each of 3 loads in random order at 1-week intervals: oral methionine, 100 mg\/kg in fruit juice; the same methionine load immediately following ingestion of antioxidant vitamin E, 800 IU, and ascorbic acid, 1000 mg; and methionine-free fruit juice (placebo). Ten of the 20 subjects also ingested a placebo load with vitamins.<\/p>\n<p>MAIN OUTCOME MEASURES: Lipid, coagulation, glucose, and circulating adhesion molecule parameters, blood pressure, and endothelial functions as assessed by hemodynamic and rheologic responses to L-arginine, evaluated at baseline and 4 hours following ingestion of the loads.<\/p>\n<p>RESULTS: The oral methionine load increased mean (SD) plasma homocysteine level from 10.5 (3.8) micromol\/L at baseline to 27.1 (6.7) micromol\/L at 4 hours (P&lt;.001). A similar increase was observed with the same load plus vitamins (10.0 [4.0] to 22.7 [7.8] micromol\/L; P&lt;.001) but no significant increase was observed with placebo (10.1 [3.7] to 10.4 [3.2] micromol\/L; P=.75). Coagulation and circulating adhesion molecule levels significantly increased after methionine ingestion alone (P&lt;.05) but not after placebo or methionine ingestion with vitamins. While the mean (SD) blood pressure (-7.0% [2.7%]; P&lt;.001), platelet aggregation response to adenosine diphosphate (-11.4% [4.5%]; P=.009) and blood viscosity (-3.0% [1.2%]; P=.04) declined in these parameters 10 minutes after an L-arginine load (3 g) following placebo, the increase after methionine alone (-2.3% [1.5%], 4.0% [3.0%], and 1.5% [1.0%], respectively; P&lt;.05), did not occur following methionine load with vitamin pretreatment (-6.3% [2.5%], -7.9% [3.5%], and -1.5% [1.0%], respectively; P=.24).<\/p>\n<p>CONCLUSION: Our data suggest that mild to moderate elevations of plasma homocysteine levels in healthy subjects activate coagulation, modify the adhesive properties of endothelium, and impair the vascular responses to L-arginine. Pretreatment with antioxidant vitamin E and ascorbic acid blocks the effects of hyperhomocysteinemia, suggesting an oxidative mechanism.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-58468","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Department of Geriatrics, Second University of Naples, Italy","annee":"1999","mois":"6","numero":"281:22","page":"2113-2118","auteurs":[{"ID":9280,"post_author":"0","post_date":"2018-12-03 18:09:24","post_date_gmt":"2018-12-03 17:09:24","post_content":"","post_title":"Dario Giugliano","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dario-giugliano","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:24","post_modified_gmt":"2018-12-03 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04:45:38","post_content":"","post_title":"Marfella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marfella","to_ping":"","pinged":"","post_modified":"2018-12-04 05:45:38","post_modified_gmt":"2018-12-04 04:45:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marfella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54769,"post_author":"0","post_date":"2018-12-04 06:49:42","post_date_gmt":"2018-12-04 05:49:42","post_content":"","post_title":"Nappo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nappo","to_ping":"","pinged":"","post_modified":"2018-12-04 06:49:42","post_modified_gmt":"2018-12-04 05:49:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nappo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":58467,"post_author":"0","post_date":"2018-12-04 07:59:03","post_date_gmt":"2018-12-04 06:59:03","post_content":"","post_title":"Perna","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"perna-2","to_ping":"","pinged":"","post_modified":"2018-12-04 07:59:03","post_modified_gmt":"2018-12-04 06:59:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/perna-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":3117,"post_author":"0","post_date":"2018-12-03 17:02:27","post_date_gmt":"2018-12-03 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