{"id":58412,"date":"1999-05-01T00:00:00","date_gmt":"2018-12-04T06:57:00","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antiproliferative-activity-of-flavonoids-on-several-cancer\/"},"modified":"2018-12-04T07:57:00","modified_gmt":"2018-12-04T06:57:00","slug":"antiproliferative-activity-of-flavonoids-on-several-cancer","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antiproliferative-activity-of-flavonoids-on-several-cancer\/","title":{"rendered":"Antiproliferative activity of flavonoids on several cancer cell lines"},"content":{"rendered":"

Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3',4',5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important for the antiproliferative activity. As to polymethoxylated flavones, C-3 hydroxyl and C-8 methoxyl groups were essential for high activity.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-58412","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"National Institute of Fruit Tree Science, Shizuoka, Japan","annee":"1999","mois":"5","numero":"63:5","page":"896-899","auteurs":[{"ID":58410,"post_author":"0","post_date":"2018-12-04 07:56:55","post_date_gmt":"2018-12-04 06:56:55","post_content":"","post_title":"Katase","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"katase","to_ping":"","pinged":"","post_modified":"2018-12-04 07:56:55","post_modified_gmt":"2018-12-04 06:56:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/katase\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57191,"post_author":"0","post_date":"2018-12-04 07:35:35","post_date_gmt":"2018-12-04 06:35:35","post_content":"","post_title":"Kawaii","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kawaii","to_ping":"","pinged":"","post_modified":"2018-12-04 07:35:35","post_modified_gmt":"2018-12-04 06:35:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kawaii\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24717,"post_author":"0","post_date":"2018-12-03 22:00:50","post_date_gmt":"2018-12-03 21:00:50","post_content":"","post_title":"Kazunori Ogawa","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kazunori-ogawa","to_ping":"","pinged":"","post_modified":"2018-12-03 22:00:50","post_modified_gmt":"2018-12-03 21:00:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kazunori-ogawa\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":58411,"post_author":"0","post_date":"2018-12-04 07:56:58","post_date_gmt":"2018-12-04 06:56:58","post_content":"","post_title":"Tomono","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"tomono","to_ping":"","pinged":"","post_modified":"2018-12-04 07:56:58","post_modified_gmt":"2018-12-04 06:56:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/tomono\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24719,"post_author":"0","post_date":"2018-12-03 22:00:52","post_date_gmt":"2018-12-03 21:00:52","post_content":"","post_title":"Masamichi Yano","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"masamichi-yano","to_ping":"","pinged":"","post_modified":"2018-12-03 22:00:52","post_modified_gmt":"2018-12-03 21:00:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/masamichi-yano\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":24748,"post_author":"0","post_date":"2018-12-03 22:01:45","post_date_gmt":"2018-12-03 21:01:45","post_content":"","post_title":"BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bioscience-biotechnology-and-biochemistry","to_ping":"","pinged":"","post_modified":"2018-12-03 22:01:45","post_modified_gmt":"2018-12-03 21:01:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/bioscience-biotechnology-and-biochemistry\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nAntiproliferative activity of flavonoids on several cancer cell lines - 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