{"id":58070,"date":"1999-12-01T00:00:00","date_gmt":"2018-12-04T06:49:15","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/beta-carotene-produces-sustained-remissions-in-patients\/"},"modified":"2018-12-04T07:49:15","modified_gmt":"2018-12-04T06:49:15","slug":"beta-carotene-produces-sustained-remissions-in-patients","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/beta-carotene-produces-sustained-remissions-in-patients\/","title":{"rendered":"Beta-carotene produces sustained remissions in patients with oral leukoplakia : results of a multicenter prospective trial"},"content":{"rendered":"<p><strong>Background: <\/strong><br \/>\nBeta-carotene has been reported to produce regressions in patients with oral leukoplakia, a pre- malignant lesion. However, previous studies have all been of short duration, with clinical response as the end point.<\/p>\n<p><strong>Objective: <\/strong><br \/>\nTo evaluate the duration of response and the need for maintenance therapy in subjects who respond to beta-carotene.Methods: In this multicenter, double-blind, placebo-controlled trial, subjects were given beta-carotene, 60 mg\/d, for 6 months. At 6 months, responders were randomized to continue beta-carotene or placebo therapy for 12 additional months.<\/p>\n<p><strong>Results: <\/strong><br \/>\nFifty-four subjects were enrolled in the trial, with 50 being evaluable. At 6 months, 26 subjects (52%) had a clinical response. Twenty-three of the 26 responders completed the second, randomized phase. Only 2 (18%) of 11 in the beta-carotene arm and 2 (17%) of 12 in the placebo arm relapsed. Baseline biopsies were performed in all patients, with dysplasia being present in 19 (38%) of the 50 evaluable patients. A second biopsy was obtained at 6 months in 23 subjects who consented to this procedure. There was improvement of at least 1 grade of dysplasia in 9 (39%), with no change in 14 (61%). Nutritional intake was assessed using food frequency questionnaires. There was no change in carotenoid intake during the trial. Responders had a lower intake of dietary fiber, fruits, folate, and vitamin E supplements than did nonresponders. Beta-Carotene levels were measured in plasma and oral cavity cells. Marked increases occurred during the 6-month induction. However, baseline levels were not restored in subjects taking placebo for 6 to 9 months after discontinuation of beta-carotene therapy.<\/p>\n<p><strong>Conclusions: <\/strong><br \/>\nThe activity of beta-carotene in patients with oral leukoplakia was confirmed. The responses produced were durable for 1 year.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-58070","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"GAREWAL HS,SO ARIZONA VET AFFAIRS HEALTHCARE SYST,SECT HEMATOL ONCOL 1 111D 3601 S 6TH AVE;TUCSON,AZ 85723 USA.hgarewal@azcc.arizona.edu\"","annee":"1999","mois":"12","numero":"125:12","page":"1305-1310","auteurs":[{"ID":58067,"post_author":"0","post_date":"2018-12-04 07:49:13","post_date_gmt":"2018-12-04 06:49:13","post_content":"","post_title":"Garewal","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"garewal","to_ping":"","pinged":"","post_modified":"2018-12-04 07:49:13","post_modified_gmt":"2018-12-04 06:49:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/garewal\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":58068,"post_author":"0","post_date":"2018-12-04 07:49:14","post_date_gmt":"2018-12-04 06:49:14","post_content":"","post_title":"Katz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"katz-5","to_ping":"","pinged":"","post_modified":"2018-12-04 07:49:14","post_modified_gmt":"2018-12-04 06:49:14","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/katz-5\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50612,"post_author":"0","post_date":"2018-12-04 05:19:31","post_date_gmt":"2018-12-04 04:19:31","post_content":"","post_title":"Meyskens","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"meyskens","to_ping":"","pinged":"","post_modified":"2018-12-04 05:19:31","post_modified_gmt":"2018-12-04 04:19:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/meyskens\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":58069,"post_author":"0","post_date":"2018-12-04 07:49:15","post_date_gmt":"2018-12-04 06:49:15","post_content":"","post_title":"ARCHIVES OF OTOLARYNGOLOGY-HEAD &amp; NECK SURGERY","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"archives-of-otolaryngology-head-neck-surgery","to_ping":"","pinged":"","post_modified":"2018-12-04 07:49:15","post_modified_gmt":"2018-12-04 06:49:15","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/archives-of-otolaryngology-head-neck-surgery\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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