{"id":57648,"date":"2000-04-01T00:00:00","date_gmt":"2018-12-04T06:42:27","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-xanthophyll-carotenoids-correlate-inversely-with\/"},"modified":"2018-12-04T07:42:27","modified_gmt":"2018-12-04T06:42:27","slug":"plasma-xanthophyll-carotenoids-correlate-inversely-with","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-xanthophyll-carotenoids-correlate-inversely-with\/","title":{"rendered":"Plasma xanthophyll carotenoids correlate inversely with indices of oxidative dna damage and lipid peroxidation"},"content":{"rendered":"

Post hoc analysis of data obtained from a study designed to modulate oxidative damage by dietary intervention revealed consistently strong inverse correlations between plasma xanthophyll carotenoids and oxidative damage indices. Thirty-seven women participated in a 14-day dietary intervention that increased mean vegetable and fruit (VF) consumption to similar to 12 servings\/day. An additional 10 subjects participated in an intervention that limited VF consumption to less than four servings per day. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in DNA isolated from peripheral lymphocytes and 8-OHdG excreted in urine were measured as indices of oxidative DNA damage. Lipid peroxidation was assessed by measuring 8-epiprostaglandin F-2 alpha, (8-EPG) in urine. Plasma levels of selected carotenoids mere also determined, with the intention of using alpha-carotene as a biochemical index of VF consumption. Urinary 8-OHdG and 8-EPG mere measured by ELISA, and plasma carotenoids were measured by high performance liquid chromatography. Lymphocyte 8-OHdG was measured by reverse phase high performance liquid chromatography with electrochemical detection. We observed that the structurally related xanthophyll carotenoids, lutein and beta-cryptoxanthin, which occur in dissimilar botanical families, were consistently inversely associated with these oxidative indices. Statistically significant inverse correlations were observed between plasma lutein and\/or beta-cryptoxanthin levels and lymphocyte 8-OHdG and urinary 8-EPG. Moreover, an inverse correlation was observed between change in plasma xanthophylls and change in lymphocyte 8-OHdG concentration that occurred during the course of the study. These data lead us to hypothesize that lutein and beta-cryptoxanthin serve as markers for the antioxidant milieu provided by plants from which they are derived. Whether these carotenoids are directly responsible for the observed antioxidant phenomena merits further investigation.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57648","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"HAEGELE AD,AMC,CANC RES CTR CTR NUTR PREVENT DIS;1600 PIERCE ST;LAKEWOOD,CO 80214 USA.haegelea@amc.org\"","annee":"2000","mois":"4","numero":"9:4","page":"421-425","auteurs":[{"ID":42833,"post_author":"0","post_date":"2018-12-04 02:56:48","post_date_gmt":"2018-12-04 01:56:48","post_content":"","post_title":"Heimendinger","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"heimendinger","to_ping":"","pinged":"","post_modified":"2018-12-04 02:56:48","post_modified_gmt":"2018-12-04 01:56:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/heimendinger\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49068,"post_author":"0","post_date":"2018-12-04 04:50:29","post_date_gmt":"2018-12-04 03:50:29","post_content":"","post_title":"Wolfe","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wolfe-2","to_ping":"","pinged":"","post_modified":"2018-12-04 04:50:29","post_modified_gmt":"2018-12-04 03:50:29","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/wolfe-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50299,"post_author":"0","post_date":"2018-12-04 05:14:15","post_date_gmt":"2018-12-04 04:14:15","post_content":"","post_title":"Gillette","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gillette","to_ping":"","pinged":"","post_modified":"2018-12-04 05:14:15","post_modified_gmt":"2018-12-04 04:14:15","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gillette\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48437,"post_author":"0","post_date":"2018-12-04 04:33:58","post_date_gmt":"2018-12-04 03:33:58","post_content":"","post_title":"Thompson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"thompson-8","to_ping":"","pinged":"","post_modified":"2018-12-04 04:33:58","post_modified_gmt":"2018-12-04 03:33:58","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/thompson-8\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57647,"post_author":"0","post_date":"2018-12-04 07:42:26","post_date_gmt":"2018-12-04 06:42:26","post_content":"","post_title":"Haegele","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"haegele-2","to_ping":"","pinged":"","post_modified":"2018-12-04 07:42:26","post_modified_gmt":"2018-12-04 06:42:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/haegele-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50301,"post_author":"0","post_date":"2018-12-04 05:14:17","post_date_gmt":"2018-12-04 04:14:17","post_content":"","post_title":"Sedlacek","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sedlacek","to_ping":"","pinged":"","post_modified":"2018-12-04 05:14:17","post_modified_gmt":"2018-12-04 04:14:17","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sedlacek\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nPlasma xanthophyll carotenoids correlate inversely with indices of oxidative dna damage and lipid peroxidation - 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