{"id":57593,"date":"2000-05-01T00:00:00","date_gmt":"2018-12-04T06:41:35","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/"},"modified":"2018-12-04T07:41:35","modified_gmt":"2018-12-04T06:41:35","slug":"plant-phenolics-decrease-intestinal-tumors-in-an-animal-model","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/","title":{"rendered":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis"},"content":{"rendered":"<p>Epidemiological studies consistently indicate that consumption of fruits and vegetables lowers cancer risk in humans and suggest that certain dietary constituents may be effective in preventing colon cancer. Plant-derived phenolic compounds manifest many beneficial effects and can potentially inhibit several stages of carcinogenesis in vivo. In this study, we investigated the efficacy of several plant-derived phenolics, including caffeic acid phenethyl ester (CAPE), curcumin, quercetin and rutin, for the prevention of tumors in C57BL\/6J-Min\/+ (Min\/+) mice. These animals bear a germline mutation in the Apc gene and spontaneously develop numerous intestinal adenomas by 15 weeks of age. At a dietary level of 0.15%, CAFE decreased tumor formation in Min\/+ mice by 63%. Curcumin induced a similar tumor inhibition. Quercetin and rutin, however, both failed to alter tumor formation at dietary levels of 2%. Examination of intestinal tissue from the treated animals showed that tumor prevention by CAFE and curcumin was associated with increased enterocyte apoptosis and proliferation. CAFE and curcumin also decreased expression of the oncoprotein beta-catenin in the enterocytes of the Min\/+ mouse, an observation previously associated with an antitumor effect, These data place the plant phenolics CAFE and curcumin among a growing list of anti-inflammatory agents that suppress Ape-associated intestinal carcinogenesis.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57593","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"BERTAGNOLLI MM,NEW YORK HOSP,CORNELL MED CTR;525 E 68TH ST;NEW YORK,NY 10021 USA.mbertagnolli@partners.org\"","annee":"2000","mois":"5","numero":"21:5","page":"921-927","auteurs":[{"ID":57586,"post_author":"0","post_date":"2018-12-04 07:41:30","post_date_gmt":"2018-12-04 06:41:30","post_content":"","post_title":"Bertagnolli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bertagnolli","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:30","post_modified_gmt":"2018-12-04 06:41:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bertagnolli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57587,"post_author":"0","post_date":"2018-12-04 07:41:31","post_date_gmt":"2018-12-04 06:41:31","post_content":"","post_title":"Bilinski","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bilinski-2","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:31","post_modified_gmt":"2018-12-04 06:41:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bilinski-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57588,"post_author":"0","post_date":"2018-12-04 07:41:31","post_date_gmt":"2018-12-04 06:41:31","post_content":"","post_title":"Carothers","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carothers","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:31","post_modified_gmt":"2018-12-04 06:41:31","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/carothers\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57589,"post_author":"0","post_date":"2018-12-04 07:41:32","post_date_gmt":"2018-12-04 06:41:32","post_content":"","post_title":"Churchill","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"churchill-2","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:32","post_modified_gmt":"2018-12-04 06:41:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/churchill-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57590,"post_author":"0","post_date":"2018-12-04 07:41:33","post_date_gmt":"2018-12-04 06:41:33","post_content":"","post_title":"Grunberger","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"grunberger","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:33","post_modified_gmt":"2018-12-04 06:41:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/grunberger\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57591,"post_author":"0","post_date":"2018-12-04 07:41:33","post_date_gmt":"2018-12-04 06:41:33","post_content":"","post_title":"Mahmoud","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mahmoud","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:33","post_modified_gmt":"2018-12-04 06:41:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mahmoud\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57592,"post_author":"0","post_date":"2018-12-04 07:41:34","post_date_gmt":"2018-12-04 06:41:34","post_content":"","post_title":"Martucci","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"martucci","to_ping":"","pinged":"","post_modified":"2018-12-04 07:41:34","post_modified_gmt":"2018-12-04 06:41:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/martucci\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45870,"post_author":"0","post_date":"2018-12-04 03:47:57","post_date_gmt":"2018-12-04 02:47:57","post_content":"","post_title":"Newmark","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"newmark","to_ping":"","pinged":"","post_modified":"2018-12-04 03:47:57","post_modified_gmt":"2018-12-04 02:47:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/newmark\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":21778,"post_author":"0","post_date":"2018-12-03 20:54:22","post_date_gmt":"2018-12-03 19:54:22","post_content":"","post_title":"CARCINOGENESIS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carcinogenesis","to_ping":"","pinged":"","post_modified":"2018-12-03 20:54:22","post_modified_gmt":"2018-12-03 19:54:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/carcinogenesis\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel<\/title>\n<meta name=\"description\" content=\"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis\" \/>\n<meta property=\"og:description\" content=\"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/\",\"name\":\"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T06:41:35+00:00\",\"dateModified\":\"2018-12-04T06:41:35+00:00\",\"description\":\"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel","description":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis","og_description":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/","name":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T06:41:35+00:00","dateModified":"2018-12-04T06:41:35+00:00","description":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plant-phenolics-decrease-intestinal-tumors-in-an-animal-model\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis"}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/57593"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=57593"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=57593"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}