{"id":57541,"date":"2000-05-01T00:00:00","date_gmt":"2018-12-04T06:40:53","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-correlation-of-glutathione-and-ascorbate-and-their\/"},"modified":"2018-12-04T07:40:53","modified_gmt":"2018-12-04T06:40:53","slug":"direct-correlation-of-glutathione-and-ascorbate-and-their","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/direct-correlation-of-glutathione-and-ascorbate-and-their\/","title":{"rendered":"Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes"},"content":{"rendered":"<p>Background: Endogenous reactive oxygen species appear to contribute to aging and cancer and dietary antioxidants, present in fruit and vegetables, counteract these effects.Objective: The objective was to examine the association between intracellular glutathione, ascorbate (vitamin C), and oc-tocopherol (vitamin E) in human lymphocytes.Design: The study group consisted of 240 healthy nonsmoking volunteers with an approximately equal number of male and female subjects subdivided into 3 age groups: 18-39, 40-59, and greater than or equal to 60 y). Glutathione, glutathione disulfide, ascorbate, and alpha-tocopherol were measured in lymphocytes by HPLC.Results: The average concentration of antioxidants in lymphocytes was 27 +\/- 8 nmol\/mg protein for glutathione, 21 +\/- 8 nmol\/mg protein for ascorbate, and 0.4 +\/- 0.2 nmol\/mg protein for alpha-tocopherol. There was a strong positive correlation between glutathione and ascorbate (r = 0.62, P &lt; 0.001). No correlation was observed for glutathione and ascorbate with alpha-tocopherol. The concentration of glutathione in lymphocytes was inversely correlated with age (r = -0.19, P &lt; 0.01), as was that of ascorbate (r = -0.22, P &lt; 0.01), with 10-20% lower values in elderly than in young and elderly subjects. The concentrations of glutathione in lymphocytes were as much as 25% higher and those of ascorbate were as much as 38% higher during the summer than during the winter. The seasonal variation of ascorbate in lymphocytes was described by a linear function for age and a periodic sine function for season.Conclusion: Glutathione and ascorbate are directly correlated in human lymphocytes.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57541","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"WAGNER JR,UNIV SHERBROOKE,INST GERIATRIE CTR RECH;PAVILLON YOUVILLE 1036 RUE BELVEDERE SUD;SHERBROOKE,PQ J1H 4C4 CANADA.rwagner@courrier.usherb.ca  \"","annee":"2000","mois":"5","numero":"71:5","page":"1194-1200","auteurs":[{"ID":57536,"post_author":"0","post_date":"2018-12-04 07:40:49","post_date_gmt":"2018-12-04 06:40:49","post_content":"","post_title":"H\u00e9l\u00e8ne Payette","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"helene-payette","to_ping":"","pinged":"","post_modified":"2018-12-04 07:40:49","post_modified_gmt":"2018-12-04 06:40:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/helene-payette\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4894,"post_author":"0","post_date":"2018-12-03 17:22:03","post_date_gmt":"2018-12-03 16:22:03","post_content":"","post_title":"Andr\u00e9 M Cantin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"andre-m-cantin","to_ping":"","pinged":"","post_modified":"2018-12-03 17:22:03","post_modified_gmt":"2018-12-03 16:22:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/andre-m-cantin\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57537,"post_author":"0","post_date":"2018-12-04 07:40:50","post_date_gmt":"2018-12-04 06:40:50","post_content":"","post_title":"Fulop","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fulop","to_ping":"","pinged":"","post_modified":"2018-12-04 07:40:50","post_modified_gmt":"2018-12-04 06:40:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fulop\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57538,"post_author":"0","post_date":"2018-12-04 07:40:51","post_date_gmt":"2018-12-04 06:40:51","post_content":"","post_title":"Lenton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lenton","to_ping":"","pinged":"","post_modified":"2018-12-04 07:40:51","post_modified_gmt":"2018-12-04 06:40:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lenton\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57539,"post_author":"0","post_date":"2018-12-04 07:40:51","post_date_gmt":"2018-12-04 06:40:51","post_content":"","post_title":"Therriault","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"therriault","to_ping":"","pinged":"","post_modified":"2018-12-04 07:40:51","post_modified_gmt":"2018-12-04 06:40:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/therriault\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57540,"post_author":"0","post_date":"2018-12-04 07:40:52","post_date_gmt":"2018-12-04 06:40:52","post_content":"","post_title":"Wagner","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wagner-3","to_ping":"","pinged":"","post_modified":"2018-12-04 07:40:52","post_modified_gmt":"2018-12-04 06:40:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/wagner-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":44192,"post_author":"0","post_date":"2018-12-04 03:19:18","post_date_gmt":"2018-12-04 02:19:18","post_content":"","post_title":"AMERICAN JOURNAL OF CLINICAL NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:19:18","post_modified_gmt":"2018-12-04 02:19:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/american-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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