{"id":57269,"date":"2000-08-01T00:00:00","date_gmt":"2018-12-04T06:36:46","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/brassica-vegetable-consumption-shifts-estrogen-metabolism\/"},"modified":"2018-12-04T07:36:46","modified_gmt":"2018-12-04T06:36:46","slug":"brassica-vegetable-consumption-shifts-estrogen-metabolism","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/brassica-vegetable-consumption-shifts-estrogen-metabolism\/","title":{"rendered":"Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women"},"content":{"rendered":"<p>Previous studies suggest that the estrogen metabolite 16 alpha-hydroxyestrone acts as a breast tumor promoter. The alternative product of estrogen metabolism, 2-hydroxyestrone, does not exhibit estrogenic properties in breast tissue, and lower values of the ratio 2-hydroxyestrone:16 alpha-hydroxyestrone (2:16) in urine may be an endocrine biomarker for greater breast cancer risk. Vegetables of the Brassica genus, such as broccoli, contain a phytochemical, which may shift estrogen metabolism and increase the 2:16 ratio. Adding 500 g\/day of broccoli to a standard diet shifts 2:16 values upward in humans; however, it is unknown as to whether healthy women are able to consume a sufficient quantity of Brassica to affect breast cancer risk through this mechanism.<\/p>\n<p>In this study, 34 healthy postmenopausal women participated in an intensive intervention designed to facilitate the addition of Brassica to the daily diet. The diet was measured by repeated 24-h recall, and estrogen metabolites were measured by enzyme immunoassay in 24-h urine samples.<\/p>\n<p>In a crude analysis, there was a nonsignificant increase in the urinary 2:16 ratio associated with greater Brassica consumption. With adjustment for other dietary parameters, Brassica vegetable consumption was associated with a statistically significant increase in 2:16 values, such that for each 10g\/day increase in Brassica consumption, there was an increase in the 2:16 ratio of 0.08 (95% confidence interval, 0.02-0.15).<\/p>\n<p>To the extent that the 2:16 ratio, as measured in urine, is associated with breast cancer risk, future research should consider Brassica vegetable consumption as a potentially effective and acceptable dietary strategy to prevent breast cancer.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57269","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"FOWKE JH,S CAROLINA CANC CTR,DIV POPULAT SCI;SUITE 301 15 RICHMOND MEM PK;COLUMBIA,SC 29203 USA\"","annee":"2000","mois":"8","numero":"9:8","page":"773-779","auteurs":[{"ID":5434,"post_author":"0","post_date":"2018-12-03 17:27:47","post_date_gmt":"2018-12-03 16:27:47","post_content":"","post_title":"James R Hebert","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"james-r-hebert","to_ping":"","pinged":"","post_modified":"2018-12-03 17:27:47","post_modified_gmt":"2018-12-03 16:27:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/james-r-hebert\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":44659,"post_author":"0","post_date":"2018-12-04 03:29:59","post_date_gmt":"2018-12-04 02:29:59","post_content":"","post_title":"Fowke","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fowke","to_ping":"","pinged":"","post_modified":"2018-12-04 03:29:59","post_modified_gmt":"2018-12-04 02:29:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fowke\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57268,"post_author":"0","post_date":"2018-12-04 07:36:46","post_date_gmt":"2018-12-04 06:36:46","post_content":"","post_title":"Longcope","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"longcope","to_ping":"","pinged":"","post_modified":"2018-12-04 07:36:46","post_modified_gmt":"2018-12-04 06:36:46","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/longcope\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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