{"id":57157,"date":"2000-08-01T00:00:00","date_gmt":"2018-12-04T06:35:05","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/activity-of-crude-extract-of-rubus-crataegifolius-roots-as\/"},"modified":"2018-12-04T07:35:05","modified_gmt":"2018-12-04T06:35:05","slug":"activity-of-crude-extract-of-rubus-crataegifolius-roots-as","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/activity-of-crude-extract-of-rubus-crataegifolius-roots-as\/","title":{"rendered":"Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitor"},"content":{"rendered":"<p style=\"text-align: justify\">The effects of methanol extract of Rubus crategifolius roots and its solvent fractions were investigated on the proliferation of MCF-7 human breast carcinoma cells. The methanol extract inhibited the proliferation of MCF-7 cells in a concentration dependent manner. Moreover, their methanol soluble (W-M) fraction had the greatest inhibitory effect on the growth of MCF-7 cells. To evaluate whether the W-M fraction affects on the cell cycle of MCF-7 cells, cells treated with this fraction were analyzed with flow cytometry. The W-M fraction increased G0\/G1 phase after 24 h-treatment and induced apoptosis after 48 h-treatment. The hallmark of apoptosis, DNA fragmentation, also appeared by W-M fraction after 48 h-treatment. Furthermore, the methanol extract and its W-M fraction inhibited the activity of the topoisomerase I enzyme in the relaxation assay. From these results, their W-M fraction as well as methanol extract of R. crategifolius roots are necessary for further studies as a potent inhibitor of the growth of cancer cells.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57157","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"College of Pharmacy, Pusan National University, Korea.","annee":"2000","mois":"8","numero":"23:4","page":"338-343","auteurs":[{"ID":17712,"post_author":"0","post_date":"2018-12-03 19:55:38","post_date_gmt":"2018-12-03 18:55:38","post_content":"","post_title":"Yingying Xu","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yingying-xu","to_ping":"","pinged":"","post_modified":"2018-12-03 19:55:38","post_modified_gmt":"2018-12-03 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06:35:01","post_content":"","post_title":"Jung","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jung-6","to_ping":"","pinged":"","post_modified":"2018-12-04 07:35:01","post_modified_gmt":"2018-12-04 06:35:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jung-6\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57153,"post_author":"0","post_date":"2018-12-04 07:35:02","post_date_gmt":"2018-12-04 06:35:02","post_content":"","post_title":"Kim","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kim-15","to_ping":"","pinged":"","post_modified":"2018-12-04 07:35:02","post_modified_gmt":"2018-12-04 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Lee","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jeong-hee-lee","to_ping":"","pinged":"","post_modified":"2018-12-03 22:19:06","post_modified_gmt":"2018-12-03 21:19:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jeong-hee-lee\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57155,"post_author":"0","post_date":"2018-12-04 07:35:04","post_date_gmt":"2018-12-04 06:35:04","post_content":"","post_title":"Wang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wang-18","to_ping":"","pinged":"","post_modified":"2018-12-04 07:35:04","post_modified_gmt":"2018-12-04 06:35:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/wang-18\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":57156,"post_author":"0","post_date":"2018-12-04 07:35:05","post_date_gmt":"2018-12-04 06:35:05","post_content":"","post_title":"ARCHIVES OF PHARMACAL RESEARCH","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"archives-of-pharmacal-research","to_ping":"","pinged":"","post_modified":"2018-12-04 07:35:05","post_modified_gmt":"2018-12-04 06:35:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/archives-of-pharmacal-research\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitor - Aprifel<\/title>\n<meta name=\"description\" content=\"Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitor - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitor\" \/>\n<meta property=\"og:description\" content=\"Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitor\" \/>\n<meta property=\"og:url\" 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