{"id":57139,"date":"2000-10-01T00:00:00","date_gmt":"2018-12-04T06:34:48","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/fruit-and-vegetable-intake-and-risk-of-cardiovascular-disease-2\/"},"modified":"2018-12-04T07:34:48","modified_gmt":"2018-12-04T06:34:48","slug":"fruit-and-vegetable-intake-and-risk-of-cardiovascular-disease-2","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/fruit-and-vegetable-intake-and-risk-of-cardiovascular-disease-2\/","title":{"rendered":"Fruit and vegetable intake and risk of cardiovascular disease: the women’s health study"},"content":{"rendered":"

BACKGROUND: <\/strong>
\nProspective data relating fruit and vegetable intake to cardiovascular disease (CVD) risk are sparse, particularly for women.<\/p>\n

OBJECTIVE:<\/strong>
\nIn a large, prospective cohort of women, we examined the hypothesis that higher fruit and vegetable intake reduces CVD risk.<\/p>\n

DESIGN: <\/strong>
\nIn 1993 we assessed fruit and vegetable intake among 39876 female health professionals with no previous history of CVD or cancer by use of a detailed food-frequency questionnaire. We subsequently followed these women for an average of 5 y for incidence of nonfatal myocardial infarction (MI), stroke, percutaneous transluminal coronary angioplasty, coronary artery bypass graft, or death due to CVD.<\/p>\n

RESULTS: <\/strong>
\nDuring 195647 person-years of follow-up, we documented 418 incident cases of CVD including 126 MIs. After adjustment for age, randomized treatment status, and smoking, we observed a significant inverse association between fruit and vegetable intake and CVD risk. For increasing quintiles of total fruit and vegetable intake (median servings\/d: 2. 6, 4.1, 5.5, 7.1, and 10.2), the corresponding relative risks (RRs) were 1.0 (reference), 0.78, 0.72, 0.68, and 0.68 (95% CI comparing the 2 extreme quintiles: 0.51, 0.92; P: for trend = 0.01). An inverse, though not statistically significant, trend remained after additional adjustment for other known CVD risk factors, with RRs of 1.0, 0.75, 0.83, 0.80, and 0.85 (95% CI for extreme quintiles: 0.61, 1.17). After excluding participants with a self-reported history of diabetes, hypertension, or high cholesterol at baseline, the multivariate-adjusted RR was 0.45 when extreme quintiles were compared (95% CI: 0.22, 0.91; P: for trend = 0.09). Higher fruit and vegetable intake was also associated with a lower risk of MI, with an adjusted RR of 0.62 for extreme quintiles (95% CI: 0.37, 1.04; P: for trend = 0.07).<\/p>\n

CONCLUSION: <\/strong>
\nThese data suggest that higher intake of fruit and vegetables may be protective against CVD and support current dietary guidelines to increase fruit and vegetable intake.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57139","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Division of Preventive Medicine and Channing Laboratory, the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. simin.liu@channing.harvard.edu","annee":"2000","mois":"10","numero":"72:4","page":"922-928","auteurs":[{"ID":1412,"post_author":"0","post_date":"2018-12-03 15:59:08","post_date_gmt":"2018-12-03 14:59:08","post_content":"","post_title":"Walter C Willett","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"walter-c-willett","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:08","post_modified_gmt":"2018-12-03 14:59:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/walter-c-willett\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":4220,"post_author":"0","post_date":"2018-12-03 17:13:34","post_date_gmt":"2018-12-03 16:13:34","post_content":"","post_title":"Joann E Manson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"joann-e-manson","to_ping":"","pinged":"","post_modified":"2018-12-03 17:13:34","post_modified_gmt":"2018-12-03 16:13:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/joann-e-manson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50633,"post_author":"0","post_date":"2018-12-04 05:19:54","post_date_gmt":"2018-12-04 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