{"id":57051,"date":"2000-08-01T00:00:00","date_gmt":"2018-12-04T06:33:13","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/metabolic-and-weight-loss-effects-of-long-term-dietary-intervention\/"},"modified":"2018-12-04T07:33:13","modified_gmt":"2018-12-04T06:33:13","slug":"metabolic-and-weight-loss-effects-of-long-term-dietary-intervention","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/metabolic-and-weight-loss-effects-of-long-term-dietary-intervention\/","title":{"rendered":"Metabolic and weight loss effects of long-term dietary intervention in obese patients: four-year results"},"content":{"rendered":"

Objective: <\/strong>
\nTo investigate the contribution of meal and snack replacements for long-term weight maintenance and risk factor reduction in obese patients.<\/p>\n

Research Methods and Procedures: <\/strong>
\nProspective, randomized, two-arm, parallel intervention for 12 weeks followed by a prospective single-arm 4-year trial in a University Hospital clinic. One hundred patients, >18 years old and with a body mass index > 25 and less than or equal to 40 kg\/m², were prescribed a 1200 to 1500 kcal\/d control diet (Group A) or an isoenergetic diet, including two meal and snack replacements (vitamin- and mineral-fortified shakes, soups, and bars) and one meal high in fruits and vegetables (Group B). Following a 3 months of weight loss, all patients were prescribed the same energy-restricted diet (1200 to 1500 kcal) with one meal and one snack replacement for an additional 4 years.<\/p>\n

Results: <\/strong>
\nAll 100 patients were evaluated at 12 weeks. Mean percentage weight loss was 1.5 +\/- 0.4% and 7.8 +\/- 0.5% (mean +\/- SEM) for Groups A and B, respectively. At 12 weeks systolic blood pressure, plasma triacylglycerol, glucose, and insulin concentrations were significantly reduced in Group B, whereas no changes occurred in Group A. After 4 years, 75% of the patients were evaluated. Total mean weight loss was 3.2 +\/- 0.8% for Group A and 8.4 +\/- 0.8% (mean +\/- SEM) for Group B. Both groups showed significant improvement in blood glucose and insulin (p < 0.001), but only Group B showed significant improvement in triacylglycerol and systolic blood pressure compared to baseline values (p < 0.001)<\/p>\n

Discussion: <\/strong>
\nProviding a structured meal plan via vitamin-and mineral-fortified liquid meal replacements is a safe and effective dietary strategy for obese patients. Long-term maintenance of weight loss with meal replacements can improve certain biomarkers of disease risk.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-57051","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"DITSCHUNEIT HH,UNIV ULM,DEPT INTERNAL MED;ROBERT KOCH STR 8;D-89081 ULM, GERMANY.herwig.ditschuneit@medizin.uni-ulm.de \"","annee":"2000","mois":"8","numero":"8:5","page":"399-402","auteurs":[{"ID":47478,"post_author":"0","post_date":"2018-12-04 04:17:53","post_date_gmt":"2018-12-04 03:17:53","post_content":"","post_title":"Sadler","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sadler","to_ping":"","pinged":"","post_modified":"2018-12-04 04:17:53","post_modified_gmt":"2018-12-04 03:17:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sadler\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57047,"post_author":"0","post_date":"2018-12-04 07:33:10","post_date_gmt":"2018-12-04 06:33:10","post_content":"","post_title":"Ditschuneit","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ditschuneit","to_ping":"","pinged":"","post_modified":"2018-12-04 07:33:10","post_modified_gmt":"2018-12-04 06:33:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ditschuneit\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57048,"post_author":"0","post_date":"2018-12-04 07:33:11","post_date_gmt":"2018-12-04 06:33:11","post_content":"","post_title":"Flechtner-mors","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"flechtner-mors","to_ping":"","pinged":"","post_modified":"2018-12-04 07:33:11","post_modified_gmt":"2018-12-04 06:33:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/flechtner-mors\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57049,"post_author":"0","post_date":"2018-12-04 07:33:11","post_date_gmt":"2018-12-04 06:33:11","post_content":"","post_title":"Johnson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"johnson-15","to_ping":"","pinged":"","post_modified":"2018-12-04 07:33:11","post_modified_gmt":"2018-12-04 06:33:11","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/johnson-15\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":57050,"post_author":"0","post_date":"2018-12-04 07:33:12","post_date_gmt":"2018-12-04 06:33:12","post_content":"","post_title":"Suchard","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"suchard","to_ping":"","pinged":"","post_modified":"2018-12-04 07:33:12","post_modified_gmt":"2018-12-04 06:33:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/suchard\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":49559,"post_author":"0","post_date":"2018-12-04 04:59:05","post_date_gmt":"2018-12-04 03:59:05","post_content":"","post_title":"OBESITY RESEARCH","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"obesity-research","to_ping":"","pinged":"","post_modified":"2018-12-04 04:59:05","post_modified_gmt":"2018-12-04 03:59:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/obesity-research\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nMetabolic and weight loss effects of long-term dietary intervention in obese patients: four-year results - 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