{"id":56676,"date":"2000-06-01T00:00:00","date_gmt":"2018-12-04T06:27:06","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/inhibition-of-beta-carotene-1515-dioxygenase-activity\/"},"modified":"2018-12-04T07:27:06","modified_gmt":"2018-12-04T06:27:06","slug":"inhibition-of-beta-carotene-1515-dioxygenase-activity","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/inhibition-of-beta-carotene-1515-dioxygenase-activity\/","title":{"rendered":"Inhibition of beta-carotene-15,15 &lsquo;-dioxygenase activity by dietary flavonoids"},"content":{"rendered":"<p>Beta-Carotene-15, 15&#039;-dioxygenase is an enzyme responsible for providing vertebrates with vitamin A by catalyzing oxidative cleavage of beta-carotene at its central double bond to two molecules of retinal in intestinal cells. However, little data have been reported regarding regulation of the enzyme activity.<\/p>\n<p>We have evaluated the effects of antioxidants and dietary flavonoids on the beta-carotene dioxygenase activity in vitro using a pig intestinal homogenate as the enzyme source. 2,6-Di-tert-butyl-4-methylphenol (BHT), a synthetic antioxidant, strongly inhibited the activity at the level of 10(-6) M (a mixed-type inhibition), whereas butylated hydroxyanisole nor-dihydroguaiaretic acid, n-propyl gallate, and curcumin were moderately inhibitory.<\/p>\n<p>Flavonoids such as luteolin, quercetin, rhamnetin, and phloretin remarkably inhibited the dioxygenase activity noncompetitively whereas flavanones, isoflavones, catechins, and anthocyanidins were less inhibitory. The structure-activity relationship indicated that catechol structure of ring B and a planar flavone structure were essential for inhibition. The enzyme inhibition was also indicated in the cultured Caco-2 cells by the significantly reduced conversion of beta-carotene to retinol when incubated with BHT and rhamnetin at 2 mu M and 5 mu M, respectively.<\/p>\n<p>The results suggest that some dietary antioxidants derived from food sources modulate conversion of beta-carotene to vitamin A in intestinal cells.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56676","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"NAGAO A,MINIST AGR FORESTRY & FISHERIES,NATL FOOD RES INST;2-1-2 KANNONDAI; TSUKUBA IBARAKI 3058642, JAPAN.","annee":"2000","mois":"6","numero":"11:6","page":"348-355","auteurs":[{"ID":44588,"post_author":"0","post_date":"2018-12-04 03:28:18","post_date_gmt":"2018-12-04 02:28:18","post_content":"","post_title":"Terao","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"terao","to_ping":"","pinged":"","post_modified":"2018-12-04 03:28:18","post_modified_gmt":"2018-12-04 02:28:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/terao\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56674,"post_author":"0","post_date":"2018-12-04 07:27:04","post_date_gmt":"2018-12-04 06:27:04","post_content":"","post_title":"Kobayashi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kobayashi-2","to_ping":"","pinged":"","post_modified":"2018-12-04 07:27:04","post_modified_gmt":"2018-12-04 06:27:04","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/kobayashi-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56675,"post_author":"0","post_date":"2018-12-04 07:27:05","post_date_gmt":"2018-12-04 06:27:05","post_content":"","post_title":"Lim","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"lim-5","to_ping":"","pinged":"","post_modified":"2018-12-04 07:27:05","post_modified_gmt":"2018-12-04 06:27:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/lim-5\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":24746,"post_author":"0","post_date":"2018-12-03 22:01:42","post_date_gmt":"2018-12-03 21:01:42","post_content":"","post_title":"Mari Maeda-Yamamoto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mari-maeda-yamamoto","to_ping":"","pinged":"","post_modified":"2018-12-03 22:01:42","post_modified_gmt":"2018-12-03 21:01:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mari-maeda-yamamoto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48933,"post_author":"0","post_date":"2018-12-04 04:48:27","post_date_gmt":"2018-12-04 03:48:27","post_content":"","post_title":"Nagao","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nagao","to_ping":"","pinged":"","post_modified":"2018-12-04 04:48:27","post_modified_gmt":"2018-12-04 03:48:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nagao\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":46948,"post_author":"0","post_date":"2018-12-04 04:09:35","post_date_gmt":"2018-12-04 03:09:35","post_content":"","post_title":"JOURNAL OF NUTRITIONAL BIOCHEMISTRY","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-nutritional-biochemistry","to_ping":"","pinged":"","post_modified":"2018-12-04 04:09:35","post_modified_gmt":"2018-12-04 03:09:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-nutritional-biochemistry\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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