{"id":56668,"date":"2000-10-01T00:00:00","date_gmt":"2018-12-04T06:26:58","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/intake-of-specific-carotenoids-and-risk-of-lung-cancer-in-2-prospective\/"},"modified":"2018-12-04T07:26:58","modified_gmt":"2018-12-04T06:26:58","slug":"intake-of-specific-carotenoids-and-risk-of-lung-cancer-in-2-prospective","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/intake-of-specific-carotenoids-and-risk-of-lung-cancer-in-2-prospective\/","title":{"rendered":"Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts"},"content":{"rendered":"

Background: <\/strong>
\nCarotenoids may reduce lung carcinogenesis because of their antioxidant properties; however, few studies have examined the relation between intakes of individual carotenoids and lung cancer risk.<\/p>\n

Objective: <\/strong>
\nThe aim of this study was to examine the relation between lung cancer risk and intakes of alpha-carotene, beta-carotene, lutein, lycopene, and beta-cryptoxanthin in 2 large cohorts.<\/p>\n

Design: <\/strong>
\nDuring a 10-y follow-up period, 275 new cases of lung cancer were diagnosed in 46924 men; during a 12-y follow-up period. 519 new cases were diagnosed in 77283 women. Carotenoid intakes were derived from the reported consumption of fruit and vegetables on food-frequency questionnaires administered at baseline and during follow-up. The data were analyzed separately for each cohort and the results were pooled to compute overall relative risks (RRs).<\/p>\n

Results:<\/strong>
\nIn the pooled analyses, alpha-carotene and lycopene intakes were significantly associated with a lower risk of lung cancer; the association with beta-carotene. lutein, and beta-cryptoxanthin intakes were inverse but not significant. Lung cancer risk was significantly lower in subjects who consumed a diet high in a variety of carotenoids (RR: 0.68; 95% CI: 0.49, 0.94 for highest compared with lowest total carotenoid score category). Inverse associations were strongest after a 4-8-y lag between dietary assessment and date of diagnosis. In subjects who never smoked, a 63% lower incidence of lung cancer was observed for the top compared with the bottom quintile of alpha-carotene intake (RR: 0.37. 95% CI: 0.18. 0.77).<\/p>\n

Conclusion: <\/strong>
\nData from 2 cohort studies suggest that several carotenoids may reduce the risk of lung cancer.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56668","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"MICHAUD DS,HARVARD UNIV,SCH PUBL HLTH DEPT NUTR; BOSTON MA 02115, USA.dominique.michaud@channing.harvard.edu\"","annee":"2000","mois":"10","numero":"72:4","page":"990-997","auteurs":[{"ID":1412,"post_author":"0","post_date":"2018-12-03 15:59:08","post_date_gmt":"2018-12-03 14:59:08","post_content":"","post_title":"Walter C Willett","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"walter-c-willett","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:08","post_modified_gmt":"2018-12-03 14:59:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/walter-c-willett\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1413,"post_author":"0","post_date":"2018-12-03 15:59:08","post_date_gmt":"2018-12-03 14:59:08","post_content":"","post_title":"Eric B Rimm","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"eric-b-rimm","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:08","post_modified_gmt":"2018-12-03 14:59:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/eric-b-rimm\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":51215,"post_author":"0","post_date":"2018-12-04 05:34:01","post_date_gmt":"2018-12-04 04:34:01","post_content":"","post_title":"Dominique S Michaud","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dominique-s-michaud","to_ping":"","pinged":"","post_modified":"2018-12-04 05:34:01","post_modified_gmt":"2018-12-04 04:34:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/dominique-s-michaud\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3239,"post_author":"0","post_date":"2018-12-03 17:03:37","post_date_gmt":"2018-12-03 16:03:37","post_content":"","post_title":"Graham A Colditz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"graham-a-colditz","to_ping":"","pinged":"","post_modified":"2018-12-03 17:03:37","post_modified_gmt":"2018-12-03 16:03:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/graham-a-colditz\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49522,"post_author":"0","post_date":"2018-12-04 04:58:23","post_date_gmt":"2018-12-04 03:58:23","post_content":"","post_title":"E L Giovannucci","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"e-l-giovannucci","to_ping":"","pinged":"","post_modified":"2018-12-04 04:58:23","post_modified_gmt":"2018-12-04 03:58:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/e-l-giovannucci\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":53192,"post_author":"0","post_date":"2018-12-04 06:15:18","post_date_gmt":"2018-12-04 05:15:18","post_content":"","post_title":"Speizer","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"speizer-2","to_ping":"","pinged":"","post_modified":"2018-12-04 06:15:18","post_modified_gmt":"2018-12-04 05:15:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/speizer-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":20887,"post_author":"0","post_date":"2018-12-03 20:41:41","post_date_gmt":"2018-12-03 19:41:41","post_content":"","post_title":"Diane Feskanich","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"diane-feskanich","to_ping":"","pinged":"","post_modified":"2018-12-03 20:41:41","post_modified_gmt":"2018-12-03 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