{"id":56594,"date":"2001-06-01T00:00:00","date_gmt":"2018-12-04T06:25:35","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/isolation-and-characterization-of-structurally-novel-antimutagenic\/"},"modified":"2018-12-04T07:25:35","modified_gmt":"2018-12-04T06:25:35","slug":"isolation-and-characterization-of-structurally-novel-antimutagenic","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/isolation-and-characterization-of-structurally-novel-antimutagenic\/","title":{"rendered":"Isolation and characterization of structurally novel antimutagenic flavonoids from spinach (Spinacia oleracea)"},"content":{"rendered":"<p style=\"text-align: justify\">Thirteen compounds, isolated from spinach (Spinacia oleracea), acted as antimutagens against the dietary carcinogen 2-amino-3-methylimidazo [4,5-f]quinoline in Salmonella typhimurium TA 98. The antimutagens were purified by preparative and micropreparative HPLC from a methanol\/water (70:30, v\/v) extract of dry spinach (commercial product) after removal of lipophilic compounds such as chlorophylls and carotenoids by solid-phase extraction (SPE). Pure active compounds were identified by instrumental analysis including FT-IR, H-1 and C-13 NMR, UV-vis spectroscopy, and mass spectrometry. All of these compounds were flavonoids and related compounds that could be attributed to five groups: (A, methylenedioxyflavonal glucuronides) 5,3 &#039; -dihydroxy-4 &#039; -methoxy-6,7-methylenedioxyflavonol 3-O-beta -glucuronide (compound 1), 5,2 &#039; ,3 &#039; -trihydroxy-4 &#039; -methoxy-6,7-methylenedioxyflavonol 3-O-beta -glucuronide (compound 2), 5-hydroxy-3 &#039; ,4 &#039; -dimethoxy-6,7-methylenedioxyflavonol 3-O-beta -glucuronide (compound 3); (B, flavonol glucuronides) 5,6,3 &#039; -trihydroxy-7,4 &#039; -dimethoxyflavonol 3-O-beta -glucuronide (compound 4), 5,6-dihydroxy-7,3 &#039; ,4 &#039; -trimethoxyflavonol 3-O-beta -glucuronide (compound 5); (C, flavonol disaccharides) 5,6,4 &#039; -trihydroxy-7,3 &#039; -dimethoxyflavonol 3-O-disaccharide (compound 6), 5,6,3 &#039; ,4 &#039; -tetrahydroxy-7-methoxyflavonol 3-O-disaccharide (compounds 7 and 8); (D, flavanones) 5,8,4 &#039; -trihydroxyflavanone (compound 9), 7,8,4 &#039; -trihydroxyflavanone (compound 10); (E, flavonoid-related compounds) compounds 11, 12, and 13 with incompletely elucidated structures. The yield of compound 1 was 0.3%, related to dry weight, whereas the yields of compounds 2-13 ranged between 0.017 and 0.069%. IC50 values (antimutagenic potencies) of the flavonol glucuronides ranged between 24.2 and 58.2 &micro;M, whereas the flavonol disaccharides (compounds 7 and 8), the flavanones (compounds 9 and 10), and the flavonoid-related glycosidic compounds 11-13 were only weakly active. The aglycons of compounds 7 and 8, however, were potent antimutagens (IC50 = 10 4 and 13.0 &micro;M, respectively).<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56594","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"EDENHARDER R,UNIV MAINZ,DEPT HYG & ENVIRONM MED;OBERE ZAHLBACHER STR 67;D-55131 MAINZ, GERMANY.edenhard@uni-mainz.de","annee":"2001","mois":"6","numero":"49:6","page":"2767-2773","auteurs":[{"ID":54111,"post_author":"0","post_date":"2018-12-04 06:32:08","post_date_gmt":"2018-12-04 05:32:08","post_content":"","post_title":"Edenharder","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"edenharder","to_ping":"","pinged":"","post_modified":"2018-12-04 06:32:08","post_modified_gmt":"2018-12-04 05:32:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/edenharder\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54112,"post_author":"0","post_date":"2018-12-04 06:32:09","post_date_gmt":"2018-12-04 05:32:09","post_content":"","post_title":"Platt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"platt","to_ping":"","pinged":"","post_modified":"2018-12-04 06:32:09","post_modified_gmt":"2018-12-04 05:32:09","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/platt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56592,"post_author":"0","post_date":"2018-12-04 07:25:33","post_date_gmt":"2018-12-04 06:25:33","post_content":"","post_title":"Keller","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"keller-4","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:33","post_modified_gmt":"2018-12-04 06:25:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/keller-4\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56593,"post_author":"0","post_date":"2018-12-04 07:25:34","post_date_gmt":"2018-12-04 06:25:34","post_content":"","post_title":"Unger","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"unger","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:34","post_modified_gmt":"2018-12-04 06:25:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/unger\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1648,"post_author":"0","post_date":"2018-12-03 16:01:16","post_date_gmt":"2018-12-03 15:01:16","post_content":"","post_title":"Journal of agricultural and food chemistry","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-agricultural-and-food-chemistry","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:16","post_modified_gmt":"2018-12-03 15:01:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-agricultural-and-food-chemistry\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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