{"id":56583,"date":"2001-07-01T00:00:00","date_gmt":"2018-12-04T06:25:12","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/geraniol-a-component-of-plant-essential-oils-inhibits-growth\/"},"modified":"2018-12-04T07:25:12","modified_gmt":"2018-12-04T06:25:12","slug":"geraniol-a-component-of-plant-essential-oils-inhibits-growth","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/geraniol-a-component-of-plant-essential-oils-inhibits-growth\/","title":{"rendered":"Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells"},"content":{"rendered":"<p>Geraniol and other monoterpenes found in essential oils of fruits and herbs have been suggested to represent a new class of agents for cancer chemoprevention. As a first step in clarifying the mode of action of geraniol on colon carcinogenesis, we studied its effects on the growth of a human colon cancer cell line (Caco-2). Geraniol (400 muM) caused a 70% inhibition of cell growth, with cells accumulating in the S transition phase of the cell cycle, and concomitant inhibition of DNA synthesis. No signs of cytotoxicity or apoptosis were detected. Geraniol caused a 50% decrease of ornithine decarboxylase activity, a key enzyme of polyamine biosynthesis, which is enhanced in cancer growth. This led to a 40% reduction of the intracellular pool of putrescine. Geraniol also activated the intracellular catabolism of polyamines, indicated by enhanced polyamine acetylation. These observations indicate that polyamine metabolism is presumably a target in the antiproliferative properties of geraniol.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56583","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"RAUL F,IRCAD,LAB NUTR CHEMOPREVENT DIGEST ONCOL;1 PL HOP,BP 426;F-67091 STRASBOURG, FRANCE.francis.raul@ircad.u-strasbg.fr\"","annee":"2001","mois":"7","numero":"298:1","page":"197-200","auteurs":[{"ID":56576,"post_author":"0","post_date":"2018-12-04 07:25:03","post_date_gmt":"2018-12-04 06:25:03","post_content":"","post_title":"Carnesecchi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"carnesecchi","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:03","post_modified_gmt":"2018-12-04 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06:25:05","post_content":"","post_title":"Duranton","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"duranton","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:05","post_modified_gmt":"2018-12-04 06:25:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/duranton\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56579,"post_author":"0","post_date":"2018-12-04 07:25:07","post_date_gmt":"2018-12-04 06:25:07","post_content":"","post_title":"Gosse","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"gosse","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:07","post_modified_gmt":"2018-12-04 06:25:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/gosse\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56580,"post_author":"0","post_date":"2018-12-04 07:25:08","post_date_gmt":"2018-12-04 06:25:08","post_content":"","post_title":"Raul","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"raul","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:08","post_modified_gmt":"2018-12-04 06:25:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/raul\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56581,"post_author":"0","post_date":"2018-12-04 07:25:10","post_date_gmt":"2018-12-04 06:25:10","post_content":"","post_title":"Schneider","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"schneider-6","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:10","post_modified_gmt":"2018-12-04 06:25:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/schneider-6\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56582,"post_author":"0","post_date":"2018-12-04 07:25:11","post_date_gmt":"2018-12-04 06:25:11","post_content":"","post_title":"Seiler","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"seiler","to_ping":"","pinged":"","post_modified":"2018-12-04 07:25:11","post_modified_gmt":"2018-12-04 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