{"id":56575,"date":"2001-06-01T00:00:00","date_gmt":"2018-12-04T06:25:00","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/chemopreventive-effects-of-scordinin-on-diethylnitrosamine\/"},"modified":"2018-12-04T07:25:00","modified_gmt":"2018-12-04T06:25:00","slug":"chemopreventive-effects-of-scordinin-on-diethylnitrosamine","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/chemopreventive-effects-of-scordinin-on-diethylnitrosamine\/","title":{"rendered":"Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats"},"content":{"rendered":"<p style=\"text-align: justify\">Modifying effects of scordinin, a biological active component in garlic, on diethylnitrosamine (DEN)- and phenobarbital (PB)-induced hepatocarcinogenesis were examined in rats. Male F344 rats, 5 weeks old, were divided into 8 groups, After a week, groups 1-5 were given DEN (100 mg\/kg body weight, i.p.) once a week for 3 weeks, whereas groups 6-8 received vehicle treatment, Group 2 was given 600 ppm scordinin-containing diet in the initiation phase. From 4 weeks after the start of experiment, groups 3 and 5 were fed scordinin, and groups 1-3 and 7 received drinking water containing 500 ppm ph, Group 6 was given scordinin diet alone throughout the experiment (24 weeks), The incidences of hepatocellular adenoma and carcinoma were significantly smaller in group 3 than those in group 1 (P &lt;0.005 and P &lt;0.05, respectively). The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P &lt;0.01 and P &lt;0.0001, respectively). Glutathione 5-transferase placental form-positive foci were also significantly decreased by scordinin treatment in the initiation or promotion phase, Scordinin significantly decreased the mean number of nucleolar organizer regions&#039; protein (AgNORs)\/nucleus in hepatocellular adenoma and carcinoma, AgNORs\/nucleus in the non-lesional area was also significantly decreased by scordinin treatment during the promotion phase. These results suggest that scordinin is a promising chemopreventive agent for liver neoplasia.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56575","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"SUGIE S,GIFU UNIV,SCH MED INST LAB ANIM;40 TSUKASA MACHI; GIFU 5008705, JAPAN.sugie@cc.gifu-u.ac.jp","annee":"2001","mois":"6","numero":"92:6","page":"603-609","auteurs":[{"ID":51604,"post_author":"0","post_date":"2018-12-04 05:40:47","post_date_gmt":"2018-12-04 04:40:47","post_content":"","post_title":"Morin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"morin-2","to_ping":"","pinged":"","post_modified":"2018-12-04 05:40:47","post_modified_gmt":"2018-12-04 04:40:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/morin-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56572,"post_author":"0","post_date":"2018-12-04 07:24:55","post_date_gmt":"2018-12-04 06:24:55","post_content":"","post_title":"Sugie","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sugie","to_ping":"","pinged":"","post_modified":"2018-12-04 07:24:55","post_modified_gmt":"2018-12-04 06:24:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sugie\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":42990,"post_author":"0","post_date":"2018-12-04 02:59:41","post_date_gmt":"2018-12-04 01:59:41","post_content":"","post_title":"Okamoto","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"okamoto","to_ping":"","pinged":"","post_modified":"2018-12-04 02:59:41","post_modified_gmt":"2018-12-04 01:59:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/okamoto\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56573,"post_author":"0","post_date":"2018-12-04 07:24:57","post_date_gmt":"2018-12-04 06:24:57","post_content":"","post_title":"Rahman","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rahman-4","to_ping":"","pinged":"","post_modified":"2018-12-04 07:24:57","post_modified_gmt":"2018-12-04 06:24:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rahman-4\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56574,"post_author":"0","post_date":"2018-12-04 07:24:59","post_date_gmt":"2018-12-04 06:24:59","post_content":"","post_title":"Ushida","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ushida","to_ping":"","pinged":"","post_modified":"2018-12-04 07:24:59","post_modified_gmt":"2018-12-04 06:24:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ushida\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30735,"post_author":"0","post_date":"2018-12-03 23:35:44","post_date_gmt":"2018-12-03 22:35:44","post_content":"","post_title":"Takashi Watanabe","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"takashi-watanabe","to_ping":"","pinged":"","post_modified":"2018-12-03 23:35:44","post_modified_gmt":"2018-12-03 22:35:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/takashi-watanabe\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":55832,"post_author":"0","post_date":"2018-12-04 07:06:34","post_date_gmt":"2018-12-04 06:06:34","post_content":"","post_title":"JAPANESE JOURNAL OF CANCER RESEARCH","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"japanese-journal-of-cancer-research","to_ping":"","pinged":"","post_modified":"2018-12-04 07:06:34","post_modified_gmt":"2018-12-04 06:06:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/japanese-journal-of-cancer-research\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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