{"id":56511,"date":"2001-07-01T00:00:00","date_gmt":"2018-12-04T06:22:56","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/"},"modified":"2018-12-04T07:22:56","modified_gmt":"2018-12-04T06:22:56","slug":"red-meat-family-history-and-increased-risk-of-gastric-cancer","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/","title":{"rendered":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability"},"content":{"rendered":"<p>Microsateliite instability (MSI) occurs frequently in sporadic gastric cancer (GC) and may define a distinctive molecular pathway of carcinogenesis.<\/p>\n<p>We evaluated the role of dietary risk factors in GC according to MSI status. A large series of 382 GC cases and 561 controls were originally identified in a population-based case-control study carried out in the high-risk area around Florence, Italy; 126 GC patients were typed for MSI status. A MSI+ phenotype was detected in 43 of 126 cases (34.1%), whereas 83 cases were classified as MSI-.<\/p>\n<p>A multinomial logistic regression model was used to compare the two subgroups of GC classified according to MSI status in the same analysis, with all of the available population controls. A case-case approach was also used. The risk of MSI+ tumors was positively associated with high consumption of red meat and meat sauce and negatively associated with consumption of white meat. A positive association was also seen with total protein and nitrite intake, whereas no relation was found with micronutrient intake. Risk was especially high among subjects reporting both a positive GC family history and a high consumption of red meat (odds ratio, 25.7; 958 confidence interval, 6.4-102.8), For MSI- tumors, a significant protective effect was associated with frequent consumption of citrus and other fresh fruit, garlic, legumes, vegetables, and olive oil and with high intake of p-carotene and other antioxidants and sugar, whereas positive associations were seen with protein and sodium intake.<\/p>\n<p>In summary, a specific dietary pattern emerged for MSI+ gastric tumors, suggesting that factors related to red meat consumption are involved in this pathway, particularly among individuals with a positive family history. In contrast, the risk of MSI- tumors was strongly reduced by the frequent consumption of fresh fruit and vegetables.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56511","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"PALLI D,CTR STUDIO & PREVENZ ONCOL,EPIDEMIOL UNIT;VIA SAN SALVI 12;I-50135 FLORENCE, ITALY.d.palli@cspo.it\"","annee":"2001","mois":"7","numero":"61:14","page":"5415-5419","auteurs":[{"ID":8775,"post_author":"0","post_date":"2018-12-03 18:03:55","post_date_gmt":"2018-12-03 17:03:55","post_content":"","post_title":"Domenico Palli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"domenico-palli","to_ping":"","pinged":"","post_modified":"2018-12-03 18:03:55","post_modified_gmt":"2018-12-03 17:03:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/domenico-palli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":30724,"post_author":"0","post_date":"2018-12-03 23:35:35","post_date_gmt":"2018-12-03 22:35:35","post_content":"","post_title":"Adriano Decarli","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"adriano-decarli","to_ping":"","pinged":"","post_modified":"2018-12-03 23:35:35","post_modified_gmt":"2018-12-03 22:35:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/adriano-decarli\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":1338,"post_author":"0","post_date":"2018-12-03 15:58:28","post_date_gmt":"2018-12-03 14:58:28","post_content":"","post_title":"Giovanna Masala","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"giovanna-masala","to_ping":"","pinged":"","post_modified":"2018-12-03 15:58:28","post_modified_gmt":"2018-12-03 14:58:28","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/giovanna-masala\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":32799,"post_author":"0","post_date":"2018-12-04 00:03:50","post_date_gmt":"2018-12-03 23:03:50","post_content":"","post_title":"Matteo A Russo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"matteo-a-russo","to_ping":"","pinged":"","post_modified":"2018-12-04 00:03:50","post_modified_gmt":"2018-12-03 23:03:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/matteo-a-russo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56506,"post_author":"0","post_date":"2018-12-04 07:22:47","post_date_gmt":"2018-12-04 06:22:47","post_content":"","post_title":"Amorosi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"amorosi","to_ping":"","pinged":"","post_modified":"2018-12-04 07:22:47","post_modified_gmt":"2018-12-04 06:22:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/amorosi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3366,"post_author":"0","post_date":"2018-12-03 17:04:53","post_date_gmt":"2018-12-03 16:04:53","post_content":"","post_title":"C Saieva","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"c-saieva","to_ping":"","pinged":"","post_modified":"2018-12-03 17:04:53","post_modified_gmt":"2018-12-03 16:04:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/c-saieva\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":29432,"post_author":"0","post_date":"2018-12-03 23:18:49","post_date_gmt":"2018-12-03 22:18:49","post_content":"","post_title":"Antonio Laguna-Camacho","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"antonio-laguna-camacho","to_ping":"","pinged":"","post_modified":"2018-12-03 23:18:49","post_modified_gmt":"2018-12-03 22:18:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/antonio-laguna-camacho\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56507,"post_author":"0","post_date":"2018-12-04 07:22:50","post_date_gmt":"2018-12-04 06:22:50","post_content":"","post_title":"Costantini","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"costantini","to_ping":"","pinged":"","post_modified":"2018-12-04 07:22:50","post_modified_gmt":"2018-12-04 06:22:50","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/costantini\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56508,"post_author":"0","post_date":"2018-12-04 07:22:52","post_date_gmt":"2018-12-04 06:22:52","post_content":"","post_title":"Falchetti","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"falchetti","to_ping":"","pinged":"","post_modified":"2018-12-04 07:22:52","post_modified_gmt":"2018-12-04 06:22:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/falchetti\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54411,"post_author":"0","post_date":"2018-12-04 06:42:35","post_date_gmt":"2018-12-04 05:42:35","post_content":"","post_title":"Fraumeni","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fraumeni","to_ping":"","pinged":"","post_modified":"2018-12-04 06:42:35","post_modified_gmt":"2018-12-04 05:42:35","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fraumeni\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56509,"post_author":"0","post_date":"2018-12-04 07:22:54","post_date_gmt":"2018-12-04 06:22:54","post_content":"","post_title":"Ottini","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ottini","to_ping":"","pinged":"","post_modified":"2018-12-04 07:22:54","post_modified_gmt":"2018-12-04 06:22:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ottini\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56510,"post_author":"0","post_date":"2018-12-04 07:22:55","post_date_gmt":"2018-12-04 06:22:55","post_content":"","post_title":"Palmirotta","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"palmirotta","to_ping":"","pinged":"","post_modified":"2018-12-04 07:22:55","post_modified_gmt":"2018-12-04 06:22:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/palmirotta\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":2103,"post_author":"0","post_date":"2018-12-03 16:52:23","post_date_gmt":"2018-12-03 15:52:23","post_content":"","post_title":"CANCER RESEARCH","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-research","to_ping":"","pinged":"","post_modified":"2018-12-03 16:52:23","post_modified_gmt":"2018-12-03 15:52:23","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-research\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel<\/title>\n<meta name=\"description\" content=\"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Red meat, family history, and increased risk of gastric cancer with microsatellite instability\" \/>\n<meta property=\"og:description\" content=\"Red meat, family history, and increased risk of gastric cancer with microsatellite instability\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/\",\"name\":\"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T06:22:56+00:00\",\"dateModified\":\"2018-12-04T06:22:56+00:00\",\"description\":\"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Red meat, family history, and increased risk of gastric cancer with microsatellite instability\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel","description":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability","og_description":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/","name":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T06:22:56+00:00","dateModified":"2018-12-04T06:22:56+00:00","description":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/red-meat-family-history-and-increased-risk-of-gastric-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Red meat, family history, and increased risk of gastric cancer with microsatellite instability"}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/56511"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=56511"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=56511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}