{"id":56408,"date":"2000-12-01T00:00:00","date_gmt":"2018-12-04T06:19:37","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/associations-between-dietary-intake-and-ki-ras-mutations\/"},"modified":"2018-12-04T07:19:37","modified_gmt":"2018-12-04T06:19:37","slug":"associations-between-dietary-intake-and-ki-ras-mutations","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/associations-between-dietary-intake-and-ki-ras-mutations\/","title":{"rendered":"Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study"},"content":{"rendered":"

Ki-ras mutations are thought to be early events in the carcinogenic process leading to colon tumors. Dietary factors associated with colon cancer may be associated with these mutations.<\/p>\n

Data from a population-based, multicenter, case-control study of colon cancer were used to determine whether dietary factors are associated with Ki-ras mutations.<\/p>\n

Ki-ras mutations were detected by direct sequencing of codons 12 and 13 of the Ki-ras gene on exon 1 from DNA obtained from archival tissue. Ki-ras data were available for 1428 cases with valid interview data; data from 2410 controls were available for comparison with cases positive and negative for Ki-ras mutations. Mutations in the Ki-ras gene were detected in 32% of tumors. Of these mutations, 32.8% were G–>A transitions in the second base of codon 12 (2G–>A). Other than cruciferous vegetables, there were no nutrients or foods associated specifically with Ki-ras mutations [odds ratio (OR) for high intake relative to low intake, 0.7; 95% confidence interval (CI), 0.5-1.0]. However, evaluation of specific types of Ki-ras mutations revealed that for each of the most common types of mutation, dietary associations existed. Dietary factors involved in DNA methylation pathways were associated with 2G–>A mutations.<\/p>\n

Comparison of individuals with and without Ki-ras mutations revealed that individuals with low levels of dietary folate (OR, 0.7; 95% CI, 0.4-1.3), vitamin B6 (OR, 0.5; 95% CI, 0.3-1.0), vitamin B12 (OR, 0.6; 95% CI, 0.3-1.1), and high levels of alcohol (OR, 0.7; 95% CI, 0.4-1.1) were less likely to have a 2G–>A mutation.
\nIndividuals with high levels of dietary carbohydrate (OR, 2.0; 95% CI, 0.9-4.4) and a high glycemic index (OR, 1.9; 95% CI, 0.8-4.6) were more likely to have a G–>A transition mutation in the second base of codon 13 (5G–>A).
\nIndividuals with high levels of dietary fat (OR, 1.6; 95% CI, 0.8-3.2), saturated fat (OR, 1.7; 95% CI, 0.8-3.5), and monounsaturated fat (OR, 1.9; 95% CI, 1.0-3.7) were more likely to harbor a 2G–>T mutation.
\nLow levels of cruciferous vegetable intake and high levels of processed meat intake also were associated with fewer 5G–>A, as reflected by the ORs (OR, 0.4; 95% CI, 0.2-1.0 and OR, 0.4; 95% CI 0.2-0.8, respectively).<\/p>\n

These data suggest that diet may be involved in disease pathways represented by specific Ki-ras mutations. However, given the limited information currently available on associations between specific genetic mutations in colon tumors and diet, these findings also should be viewed as hypothesis generating.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56408","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City 84108, USA.","annee":"2000","mois":"12","numero":"60:24","page":"6935-6941","auteurs":[{"ID":52161,"post_author":"0","post_date":"2018-12-04 05:55:48","post_date_gmt":"2018-12-04 04:55:48","post_content":"","post_title":"Curtin","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"curtin","to_ping":"","pinged":"","post_modified":"2018-12-04 05:55:48","post_modified_gmt":"2018-12-04 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