{"id":56302,"date":"2001-06-01T00:00:00","date_gmt":"2018-12-04T06:16:22","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/human-exposures-to-monomers-resulting-from-consumer-contact\/"},"modified":"2018-12-04T07:16:22","modified_gmt":"2018-12-04T06:16:22","slug":"human-exposures-to-monomers-resulting-from-consumer-contact","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/human-exposures-to-monomers-resulting-from-consumer-contact\/","title":{"rendered":"Human exposures to monomers resulting from consumer contact with polymers"},"content":{"rendered":"<p>Many consumer products are composed completely, or in part, of polymeric materials. Direct or indirect human contact results in potential exposures to monomers as a result of migrations of trace amounts from the polymeric matrix into foods, into the skin or other bodily surfaces. Typically, residual monomer levels in these polymers are &lt;100 p.p.m.. and represent exposures well below those observable in traditional toxicity testing. These product applications thus require alternative methods for evaluating health risks relating to monomer exposures. A typical approach includes: (a) assessment of potential human contacts for specific polymer uses; (b) utilization of data from toxicity testing of pure monomers, e.g. cancer bioassay results; and (c) mathematical risk assessment methods. Exposure potentials are measured in one of two analytical procedures: (1) migration of monomer from polymer into a simulant solvent (e.g. alcohol, acidic water, vegetable oil) appropriate for the intended use of the product (e.g. beer cans, food jars, packaging adhesive, dairy hose): or (2) total monomer content of the polymer, providing worse-case values for migratable monomer, Application of toxicity data typically involves NOEL or benchmark values for non-cancer endpoints, or tumorigenicity potencies for monomers demonstrated to be carcinogens. Risk assessments provide exposure &#039;safety margin&#039; ratios between levels that: (1) are projected to be safe according to toxicity information, and (2) are potential monomer exposures posed by the intended use of the consumer product. This paper includes an example of a health risk assessment for a chewing gum polymer for which exposures to trace levels of butadiene monomer occur.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56302","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"LEBER AP,GOODYEAR TIRE & RUBBER CO;1485 E ARCHWOOD AVE; AKRON OH 44306, USA.apleber@goodyear.com\"","annee":"2001","mois":"6","numero":"135","page":"215-220","auteurs":[{"ID":56301,"post_author":"0","post_date":"2018-12-04 07:16:22","post_date_gmt":"2018-12-04 06:16:22","post_content":"","post_title":"AP Leber","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ap-leber","to_ping":"","pinged":"","post_modified":"2018-12-04 07:16:22","post_modified_gmt":"2018-12-04 06:16:22","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ap-leber\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":19306,"post_author":"0","post_date":"2018-12-03 20:19:25","post_date_gmt":"2018-12-03 19:19:25","post_content":"","post_title":"CHEMICO-BIOLOGICAL INTERACTIONS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"chemico-biological-interactions","to_ping":"","pinged":"","post_modified":"2018-12-03 20:19:25","post_modified_gmt":"2018-12-03 19:19:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/chemico-biological-interactions\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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