{"id":56224,"date":"2001-10-01T00:00:00","date_gmt":"2018-12-04T06:13:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/selective-growth-inhibitory-cell-cycle-deregulatory-and\/"},"modified":"2018-12-04T07:13:41","modified_gmt":"2018-12-04T06:13:41","slug":"selective-growth-inhibitory-cell-cycle-deregulatory-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/selective-growth-inhibitory-cell-cycle-deregulatory-and\/","title":{"rendered":"Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells"},"content":{"rendered":"<p>Agents that are capable of inducing selective apoptosis of cancer cells are receiving considerable attention in developing novel cancer-preventive approaches. In the present study, employing normal human prostate epithelial cells (NHPE), virally transformed normal human prostate epithelial cells (PZ-HPV-7), and human prostate adenocarcinoma (CA-HPV-10) cells, we evaluated the growth-inhibitory effects of apigenin, a flavonoid abundantly present in fruits and vegetables. Apigenin treatment to NHPE and PZ-HPV-7 resulted in almost similar growth inhibitory responses of low magnitude. In sharp contrast, apigenin treatment resulted in a significant decrease in cell viability of CA-HPV-10 cells. Similar selective growth inhibitory effects were also observed for human epidermoid carcinoma A431 cells compared to normal human epidermal keratinocytes. Apigenin treatment resulted in significant apoptosis of CA-HPV-10 cells as evident from (i) DNA ladder assay, (ii) fluorescence microscopy, and (iii) TUNEL assay, whereas the NHPE and PZ-HPV-7 cells did not undergo apoptosis but showed exclusive necrotic staining only at a high dose of 40 muM. Apigenin (1-10 muM) also resulted in a dose-dependent G2-M phase cell cycle arrest of CA-HPV-10 cells but not of PZ-HPV-7 cells. The growth-inhibitory and apoptotic potential of apigenin was also observed in a variety of prostate carcinoma cells representing different stage and androgen responsiveness. Apigenin may be developed as a promising chemopreventive and\/or chemotherapeutic agent against prostate cancer.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56224","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"GUPTA S,CASE WESTERN RESERVE UNIV,DEPT DERMATOL;11100 EUCLID AVE; CLEVELAND OH 44106, USA.gxs44@po.cwru.edu\"","annee":"2001","mois":"10","numero":"287:4","page":"914-920","auteurs":[{"ID":35384,"post_author":"0","post_date":"2018-12-04 00:43:20","post_date_gmt":"2018-12-03 23:43:20","post_content":"","post_title":"Mukhtar","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mukhtar","to_ping":"","pinged":"","post_modified":"2018-12-04 00:43:20","post_modified_gmt":"2018-12-03 23:43:20","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mukhtar\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":31397,"post_author":"0","post_date":"2018-12-03 23:44:33","post_date_gmt":"2018-12-03 22:44:33","post_content":"","post_title":"Sanjeev Kumar Gupta","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"sanjeev-kumar-gupta","to_ping":"","pinged":"","post_modified":"2018-12-03 23:44:33","post_modified_gmt":"2018-12-03 22:44:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/sanjeev-kumar-gupta\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":15485,"post_author":"0","post_date":"2018-12-03 19:26:54","post_date_gmt":"2018-12-03 18:26:54","post_content":"","post_title":"Farrukh Afaq","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"farrukh-afaq","to_ping":"","pinged":"","post_modified":"2018-12-03 19:26:54","post_modified_gmt":"2018-12-03 18:26:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/farrukh-afaq\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":49155,"post_author":"0","post_date":"2018-12-04 04:51:57","post_date_gmt":"2018-12-04 03:51:57","post_content":"","post_title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"biochemical-and-biophysical-research-communications","to_ping":"","pinged":"","post_modified":"2018-12-04 04:51:57","post_modified_gmt":"2018-12-04 03:51:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/biochemical-and-biophysical-research-communications\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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