{"id":56160,"date":"2001-11-01T00:00:00","date_gmt":"2018-12-04T06:11:47","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/influence-of-dietary-fatty-acid-vegetable-and-vitamin-intake\/"},"modified":"2018-12-04T07:11:47","modified_gmt":"2018-12-04T06:11:47","slug":"influence-of-dietary-fatty-acid-vegetable-and-vitamin-intake","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/influence-of-dietary-fatty-acid-vegetable-and-vitamin-intake\/","title":{"rendered":"Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers: a pilot study."},"content":{"rendered":"<p>Etheno-DNA adducts such as 1,N-6-ethenodeoxyadenosine (epsilon dA) and N-2,3-ethenodeoxycytidine (epsilon dC) are formed as result of oxidative stress and lipid peroxidation via reactive alkenals (J. Nair et al., Mutat. Res., 424: 59-69, 1999). High &lt;()over bar&gt;-6 polyunsaturated fatty acid intake markedly increased levels of WBCs in female volunteers on a controlled diet (J. Nair et al., Cancer Epidemiol. Biomark. Prev., 6: 591-601, 1997). In healthy female volunteers we investigated possible correlations between dietary fatty acid intake (by questionnaire), concentration of linoleic acid (LA) and oleic acid (OA) in serum (n = 34), and etheno-DNA adduct levels in WBC (n = 42). Two groups of samples were selected according to dietary intake &gt; 15 g (group A) or &lt;5 g (group B) LA\/day. Serum samples were analyzed for free OA and LA by gas chromatography-mass spectroscopy and WBC-DNA for epsilon dA and epsilon dC adducts by immunoaffinity P-32 postlabeling. On a group level, serum LA and OA concentrations were higher in group A than group B, whereas the LA\/OA ratios were similar. The mean epsilon dA and epsilon dC levels did not significantly differ in groups A and B, but a third of the individuals had more than twice the mean adduct levels than the rest. Correlation analyses revealed a significant inverse correlation for epsilon dA in WBC-DNA and vegetable or vitamin E consumption. We conclude that etheno-DNA adduct levels are not determined by LA intake alone but might depend on the ratio of &lt;()over bar&gt;-6 polyunsaturated fatty acid:other fatty acids and of antioxidants consumed in the diet. This pilot study also indicated a protective effect of dietary vitamin E and vegetables against miscoding, lipid peroxidation-induced DNA lesions.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-56160","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"BARTSCH H,DEUTSCH KREBSFORSCHUNGSZENTRUM,GERMAN CANC RES CTR DIV TOXICOL & CANC RISK FACTORS;NEUENHEIMER FELD 280;D-69120 HEIDELBERG, GERMANY.h.bartsch@dkfz.de  \"","annee":"2001","mois":"11","numero":"10:11","page":"1187-1191","auteurs":[{"ID":46516,"post_author":"0","post_date":"2018-12-04 04:00:34","post_date_gmt":"2018-12-04 03:00:34","post_content":"","post_title":"Becker","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"becker","to_ping":"","pinged":"","post_modified":"2018-12-04 04:00:34","post_modified_gmt":"2018-12-04 03:00:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/becker\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56158,"post_author":"0","post_date":"2018-12-04 07:11:43","post_date_gmt":"2018-12-04 06:11:43","post_content":"","post_title":"Korfmann","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"korfmann","to_ping":"","pinged":"","post_modified":"2018-12-04 07:11:43","post_modified_gmt":"2018-12-04 06:11:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/korfmann\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48879,"post_author":"0","post_date":"2018-12-04 04:46:52","post_date_gmt":"2018-12-04 03:46:52","post_content":"","post_title":"Bartsch","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"bartsch","to_ping":"","pinged":"","post_modified":"2018-12-04 04:46:52","post_modified_gmt":"2018-12-04 03:46:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/bartsch\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":56159,"post_author":"0","post_date":"2018-12-04 07:11:45","post_date_gmt":"2018-12-04 06:11:45","post_content":"","post_title":"Hagenlocher","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"hagenlocher","to_ping":"","pinged":"","post_modified":"2018-12-04 07:11:45","post_modified_gmt":"2018-12-04 06:11:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/hagenlocher\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":48880,"post_author":"0","post_date":"2018-12-04 04:46:53","post_date_gmt":"2018-12-04 03:46:53","post_content":"","post_title":"Nair","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nair-3","to_ping":"","pinged":"","post_modified":"2018-12-04 04:46:53","post_modified_gmt":"2018-12-04 03:46:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nair-3\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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