{"id":55650,"date":"2001-01-01T00:00:00","date_gmt":"2018-12-04T06:03:41","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/vitamin-a-intake-and-hip-fractures-among-postmenopausal-women\/"},"modified":"2018-12-04T07:03:41","modified_gmt":"2018-12-04T06:03:41","slug":"vitamin-a-intake-and-hip-fractures-among-postmenopausal-women","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/vitamin-a-intake-and-hip-fractures-among-postmenopausal-women\/","title":{"rendered":"Vitamin A intake and hip fractures among postmenopausal women"},"content":{"rendered":"<p><strong>Context <\/strong><br \/>\nIngestion of toxic amounts of vitamin A affects bone remodeling and can have adverse skeletal effects in animals. The possibility has been raised that long-term high vitamin A intake could contribute to fracture risk in humans.<\/p>\n<p><strong>Objective <\/strong><br \/>\nTo assess the relationship between high vitamin A intake from foods and supplements and risk of hip fracture among postmenopausal women.<\/p>\n<p><strong>Design <\/strong><br \/>\nProspective analysis begun in 1980 with 18 years of follow-up within the Nurses&#039; Health Study.<\/p>\n<p><strong>Setting <\/strong><br \/>\nGeneral community of registered nurses within 11 US states.<\/p>\n<p><strong>Participants <\/strong><br \/>\nA total of 72337 postmenopausal women aged 34 to 77 years.<\/p>\n<p><strong>Main Outcome Measures<\/strong><br \/>\nIncident hip fractures resulting from low or moderate trauma, analyzed by quintiles of vitamin A intake and by use of multivitamins and vitamin A supplements, assessed at baseline and updated during follow-up.<\/p>\n<p><strong>Results<\/strong><br \/>\nFrom 1980 to 1998, 603 incident hip fractures resulting from low or moderate trauma were identified. After controlling for confounding factors, women in the highest quintile of total vitamin A intake (greater than or equal to 3000 &micro;g\/d of retinol equivalents [RE]) had a significantly elevated relative risk (RR) of hip fracture (RR, 1.48; 95% confidence interval [CI], 1.05-2.07; P for trend =.003) compared with women in the lowest quintile of intake (&lt;1250 g\/d of RE). This increased risk was attributable primarily to retinol (RR, 1.89; 95% CI, 1.33-2.68; P for trend &lt;.001 comparing 2000 &micro;g\/d vs &lt;500 g\/d). The association of high retinol intake with hip fracture was attenuated among women using postmenopausal estrogens. Beta carotene did not contribute significantly to fracture risk (RR, 1.22; 95% CI, 0.90-1.66; P for trend=.10 comparing greater than or equal to 6300 mug\/d vs &lt;2550 g\/d). Women currently taking a specific vitamin A supplement had a nonsignificant 40% increased risk of hip fracture (RR, 1.40; 95% CI, 0.99-1.99) compared with those not taking that supplement, and, among women not taking supplemental vitamin A, retinol from food was significantly associated with fracture risk (RR, 1.69; 95% CI, 1.05-2.74; P for trend =.05 comparing greater than or equal to 1000 mug\/d vs &lt;400 g\/d).<\/p>\n<p><strong>Conclusions <\/strong><br \/>\nLong-term intake of a diet high in retinol may promote the development of osteoporotic hip fractures in women. The amounts of retinol in fortified foods and vitamin supplements may need to be reassessed.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-55650","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"FESKANICH D,CHANNING LABS;181 LONGWOOD AVE; BOSTON MA 02115, USA.diane.feskanich@channing.harvard.edu  \"","annee":"2001","mois":"1","numero":"287:1","page":"47-54","auteurs":[{"ID":1412,"post_author":"0","post_date":"2018-12-03 15:59:08","post_date_gmt":"2018-12-03 14:59:08","post_content":"","post_title":"Walter C Willett","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"walter-c-willett","to_ping":"","pinged":"","post_modified":"2018-12-03 15:59:08","post_modified_gmt":"2018-12-03 14:59:08","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/walter-c-willett\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":3239,"post_author":"0","post_date":"2018-12-03 17:03:37","post_date_gmt":"2018-12-03 16:03:37","post_content":"","post_title":"Graham A Colditz","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"graham-a-colditz","to_ping":"","pinged":"","post_modified":"2018-12-03 17:03:37","post_modified_gmt":"2018-12-03 16:03:37","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/graham-a-colditz\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":20887,"post_author":"0","post_date":"2018-12-03 20:41:41","post_date_gmt":"2018-12-03 19:41:41","post_content":"","post_title":"Diane Feskanich","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"diane-feskanich","to_ping":"","pinged":"","post_modified":"2018-12-03 20:41:41","post_modified_gmt":"2018-12-03 19:41:41","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/diane-feskanich\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":47520,"post_author":"0","post_date":"2018-12-04 04:18:24","post_date_gmt":"2018-12-04 03:18:24","post_content":"","post_title":"Singh","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"singh-5","to_ping":"","pinged":"","post_modified":"2018-12-04 04:18:24","post_modified_gmt":"2018-12-04 03:18:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/singh-5\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":47347,"post_author":"0","post_date":"2018-12-04 04:16:03","post_date_gmt":"2018-12-04 03:16:03","post_content":"","post_title":"JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jama-journal-of-the-american-medical-association","to_ping":"","pinged":"","post_modified":"2018-12-04 04:16:03","post_modified_gmt":"2018-12-04 03:16:03","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/jama-journal-of-the-american-medical-association\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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