{"id":55409,"date":"2002-05-01T00:00:00","date_gmt":"2018-12-04T05:59:56","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/methylation-of-quercetin-and-fisetin-flavonoids-widely-distributed\/"},"modified":"2018-12-04T06:59:56","modified_gmt":"2018-12-04T05:59:56","slug":"methylation-of-quercetin-and-fisetin-flavonoids-widely-distributed","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/methylation-of-quercetin-and-fisetin-flavonoids-widely-distributed\/","title":{"rendered":"Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver"},"content":{"rendered":"

The aim of this investigation was to study the methylation of quercetin and fisetin, 2 chemically related flavonoids, in human liver and to this purpose, an assay, was set-up to measure the rates of quercetin and fisetin methylation in human liver. The methylation rates (pmol\/min\/mg) Of quercetin and fisetin were measured in 10 liver samples and the mean +\/- SD and the median were 170 +\/- 30 and 177 (quercetin) and 183 15 and 178 (fisetin). The rates of quercetin and fisetin methylation were not different (p = 0.283). The fold of variation among samples as 2 (quercetin) and 1.3 (fisetin). Methytransferase towards quercetin and fisetin followed Michaelis-Menten kinetics, and the K-m values were 2.6 +\/- 0.3 (quercetin) and 8,6 +\/- 0.7 muM (fisetin. p = 0.009) and the V-max values were 187 +\/- 20 (quercetin) and 276 +\/- 33 pmol\/min\/mg (fisetin, p = 0.009). Two. 4 and 8 mul of red Chianti wine added to the incubation mixture reduced the rate of quercetin methylation to 75 +\/- 4%, 65 +\/- 9% and 59 +\/- 9%, respectively, and that of fisetin methylation to 62 +\/- 3%, 51 +\/- 3% and 44 +\/- 4%. respectively. In conclusion. quercetin and fisetin are methylated in human liver and their rates of methylation have a limited variation among subjects.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-55409","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"PACIFICI GM,UNIV PISA,SCH MED DEPT NEUROSCI PHARMACOL SECT;VIA ROMA 55;I-56126 PISA, ITALY.pacifici@biomed.unipi.it \"","annee":"2002","mois":"5","numero":"40:5","page":"207-212","auteurs":[{"ID":55404,"post_author":"0","post_date":"2018-12-04 06:59:53","post_date_gmt":"2018-12-04 05:59:53","post_content":"","post_title":"De Santi","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"de-santi","to_ping":"","pinged":"","post_modified":"2018-12-04 06:59:53","post_modified_gmt":"2018-12-04 05:59:53","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/de-santi\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":55405,"post_author":"0","post_date":"2018-12-04 06:59:54","post_date_gmt":"2018-12-04 05:59:54","post_content":"","post_title":"Mosca","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mosca-2","to_ping":"","pinged":"","post_modified":"2018-12-04 06:59:54","post_modified_gmt":"2018-12-04 05:59:54","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mosca-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":55406,"post_author":"0","post_date":"2018-12-04 06:59:55","post_date_gmt":"2018-12-04 05:59:55","post_content":"","post_title":"Pacifici","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pacifici","to_ping":"","pinged":"","post_modified":"2018-12-04 06:59:55","post_modified_gmt":"2018-12-04 05:59:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pacifici\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":55407,"post_author":"0","post_date":"2018-12-04 06:59:55","post_date_gmt":"2018-12-04 05:59:55","post_content":"","post_title":"Pietrabissa","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pietrabissa","to_ping":"","pinged":"","post_modified":"2018-12-04 06:59:55","post_modified_gmt":"2018-12-04 05:59:55","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pietrabissa\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":55408,"post_author":"0","post_date":"2018-12-04 06:59:56","post_date_gmt":"2018-12-04 05:59:56","post_content":"","post_title":"INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"international-journal-of-clinical-pharmacology-and-therapeutics","to_ping":"","pinged":"","post_modified":"2018-12-04 06:59:56","post_modified_gmt":"2018-12-04 05:59:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/international-journal-of-clinical-pharmacology-and-therapeutics\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nMethylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver - 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