{"id":55212,"date":"2002-09-01T00:00:00","date_gmt":"2018-12-04T05:57:01","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dietary-carotenoids-serum-beta-carotene-and-retinol-and\/"},"modified":"2018-12-04T06:57:01","modified_gmt":"2018-12-04T05:57:01","slug":"dietary-carotenoids-serum-beta-carotene-and-retinol-and","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/dietary-carotenoids-serum-beta-carotene-and-retinol-and\/","title":{"rendered":"Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study"},"content":{"rendered":"<p>Findings from several beta-carotene supplementation trials were unexpected and conflicted with most observational studies. Carotenoids other than beta-carotene are found in a variety of fruits and vegetables and may play a role in this important malignancy, but previous findings regarding the five major carotenoids are inconsistent. The authors analyzed the associations between dietary beta-carotene, beta-carotene, lutein\/zeaxanthin, lycopene, beta-cryptoxanthin, vitamin A, serum beta-carotene, and serum retinol and the lung cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers conducted in southwestern Finland between 1985 and 1993. Of the 27,084 male smokers aged 50-69 years who completed the 276-food item dietary questionnaire at baseline, 1,644 developed lung cancer during up to 14 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. Consumption of fruits and vegetables was associated with a lower lung cancer risk (relative risk = 0.73, 95% confidence interval: 0.62, 0.86, highest vs. lowest quintile). Lower risks of lung cancer were observed for the highest versus the lowest quintiles of lycopene (28%), lutein\/zeaxanthin (17%), beta-cryptoxanthin (15%), total carotenoids (16%), serum beta-carotene (19%), and serum retinol (27%). These findings suggest that high fruit and vegetable consumption, particularly a diet rich in carotenoids, tomatoes, and tomato-based products, may reduce the risk of lung cancer.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-55212","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"MICHAUD DS,NCI,DIV CANC EPIDEMIOL & GENET;EPS-320 MSC 7232,6120 EXECUT BLVD; BETHESDA MD 20892, USA.michaudd@mail.nih.gov  \"","annee":"2002","mois":"9","numero":"156:6","page":"536-547","auteurs":[{"ID":51215,"post_author":"0","post_date":"2018-12-04 05:34:01","post_date_gmt":"2018-12-04 04:34:01","post_content":"","post_title":"Dominique S Michaud","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dominique-s-michaud","to_ping":"","pinged":"","post_modified":"2018-12-04 05:34:01","post_modified_gmt":"2018-12-04 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Mayne","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"s-t-mayne","to_ping":"","pinged":"","post_modified":"2018-12-03 23:14:07","post_modified_gmt":"2018-12-03 22:14:07","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/s-t-mayne\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":14420,"post_author":"0","post_date":"2018-12-03 19:09:30","post_date_gmt":"2018-12-03 18:09:30","post_content":"","post_title":"Demetrius Albanes","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"demetrius-albanes","to_ping":"","pinged":"","post_modified":"2018-12-03 19:09:30","post_modified_gmt":"2018-12-03 18:09:30","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/demetrius-albanes\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":40791,"post_author":"0","post_date":"2018-12-04 02:21:40","post_date_gmt":"2018-12-04 01:21:40","post_content":"","post_title":"Pietinen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"pietinen","to_ping":"","pinged":"","post_modified":"2018-12-04 02:21:40","post_modified_gmt":"2018-12-04 01:21:40","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/pietinen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28894,"post_author":"0","post_date":"2018-12-03 23:11:57","post_date_gmt":"2018-12-03 22:11:57","post_content":"","post_title":"Jarmo Virtamo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jarmo-virtamo","to_ping":"","pinged":"","post_modified":"2018-12-03 23:11:57","post_modified_gmt":"2018-12-03 22:11:57","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jarmo-virtamo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":34293,"post_author":"0","post_date":"2018-12-04 00:26:38","post_date_gmt":"2018-12-03 23:26:38","post_content":"","post_title":"Stolzenberg-solomon","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"stolzenberg-solomon","to_ping":"","pinged":"","post_modified":"2018-12-04 00:26:38","post_modified_gmt":"2018-12-03 23:26:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/stolzenberg-solomon\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49523,"post_author":"0","post_date":"2018-12-04 04:58:24","post_date_gmt":"2018-12-04 03:58:24","post_content":"","post_title":"Holick","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"holick","to_ping":"","pinged":"","post_modified":"2018-12-04 04:58:24","post_modified_gmt":"2018-12-04 03:58:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/holick\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":2252,"post_author":"0","post_date":"2018-12-03 16:53:48","post_date_gmt":"2018-12-03 15:53:48","post_content":"","post_title":"American journal of 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