{"id":55138,"date":"2002-09-01T00:00:00","date_gmt":"2018-12-04T05:55:52","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/potential-neurotoxic-agents-provocateurs-in-parkinson-s\/"},"modified":"2018-12-04T06:55:52","modified_gmt":"2018-12-04T05:55:52","slug":"potential-neurotoxic-agents-provocateurs-in-parkinson-s","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/potential-neurotoxic-agents-provocateurs-in-parkinson-s\/","title":{"rendered":"Potential neurotoxic \u00ab\u00a0agents provocateurs\u00a0\u00bb in Parkinson’s disease"},"content":{"rendered":"

Idiopathic Parkinson's disease (PD), one of the most common neurodegenerative disorders associated with aging, is characterized neurochemically by abnormal and profound loss of nigrostriatal dopamine (DA) neurons. A prominent current view is that the excessive degeneration of the dopaminergic system is the outcome of extended insults by environmental neurotoxins or endogenous neurotoxic factors in genetically vulnerable or susceptible individuals. Recent insights into the identities and mechanisms of potential neurotoxic species, which span pesticides, environmental contaminants including heterocyclic amines with beta-carboline (betaC) and isoquinoline (IQ) structures, endogenous DA metabolites or intermediates, neuromelanin, metals, and infectious agents, are presented.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-55138","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"COLLINS MA,LOYOLA UNIV,SCH MED DIV BIOCHEM DEPT CELL BIOL NEUROBIOL & ANAT;2160 S 1ST AVE; MAYWOOD IL 60153, USA.mcollin@lumc.edu\"","annee":"2002","mois":"9","numero":"24:5","page":"571-577","auteurs":[{"ID":55135,"post_author":"0","post_date":"2018-12-04 06:55:51","post_date_gmt":"2018-12-04 05:55:51","post_content":"","post_title":"Collins","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"collins-6","to_ping":"","pinged":"","post_modified":"2018-12-04 06:55:51","post_modified_gmt":"2018-12-04 05:55:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/collins-6\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":55136,"post_author":"0","post_date":"2018-12-04 06:55:51","post_date_gmt":"2018-12-04 05:55:51","post_content":"","post_title":"Neafsey","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"neafsey","to_ping":"","pinged":"","post_modified":"2018-12-04 06:55:51","post_modified_gmt":"2018-12-04 05:55:51","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/neafsey\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":55137,"post_author":"0","post_date":"2018-12-04 06:55:52","post_date_gmt":"2018-12-04 05:55:52","post_content":"","post_title":"NEUROTOXICOLOGY AND TERATOLOGY","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"neurotoxicology-and-teratology","to_ping":"","pinged":"","post_modified":"2018-12-04 06:55:52","post_modified_gmt":"2018-12-04 05:55:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/neurotoxicology-and-teratology\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nPotential neurotoxic "agents provocateurs" in Parkinson's disease - 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