{"id":54901,"date":"2002-07-01T00:00:00","date_gmt":"2018-12-04T05:52:06","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/"},"modified":"2018-12-04T06:52:06","modified_gmt":"2018-12-04T05:52:06","slug":"lyophilized-apple-counteracts-the-development-of-hypercholesterolemia","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/","title":{"rendered":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats"},"content":{"rendered":"<p style=\"text-align: justify\">Apples may have selective effects on abnormalities associated with the plurimetabolic syndrome. Therefore, the effects of 20% lyophilized apple supplementation on plasma and tissue lipids and on protection against susceptibility to oxidative stress and renal dysfunction were investigated in Zucker lean (Fa\/-) or obese (fa\/fa) rats. The experimental diets were equilibrated for sugar supply, contained 0.25 g\/100 g cholesterol and provided only one third of the vitamin E requirement. Obese Zucker rats were hypercholesterolemic with cholesterol accumulation in LDL and HDL fractions. The apple diet lowered plasma and LDL cholesterol (-22 and -70%, respectively, P &lt; 0.01) in obese Zucker rats and, in parallel, reduced triglyceride accumulation in heart and liver. Zucker rats fed the apple diet also had a larger intestinal pool and greater fecal excretion of bile acids. The heart concentration and urinary excretion of malondialdehyde were reduced by apple consumption in obese Zucker rats, suggesting better protection against peroxidation. Glucosuria and proteinuria in obese Zucker rats were also suppressed by the apple diet. In conclusion, despite their moderate fiber content, apples improve substantially the lipid status and peroxidative parameters in obese Zucker rats, suggesting that other plant constituents such as polyphenols are involved in these effects.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54901","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"DEMIGNE C,INRA CLERMONT FERRAND THEIX,UNITE MALAD METAB & MICRONUTRIMENTS;F-63122 ST GENES CHAMPANELLE, FRANCE.demigne@clermont.inra.fr","annee":"2002","mois":"7","numero":"132:7","page":"1969-1976","auteurs":[{"ID":2756,"post_author":"0","post_date":"2018-12-03 16:58:52","post_date_gmt":"2018-12-03 15:58:52","post_content":"","post_title":"Claudine Manach","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"claudine-manach","to_ping":"","pinged":"","post_modified":"2018-12-03 16:58:52","post_modified_gmt":"2018-12-03 15:58:52","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/claudine-manach\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50781,"post_author":"0","post_date":"2018-12-04 05:23:59","post_date_gmt":"2018-12-04 04:23:59","post_content":"","post_title":"Aprikian","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"aprikian","to_ping":"","pinged":"","post_modified":"2018-12-04 05:23:59","post_modified_gmt":"2018-12-04 04:23:59","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/aprikian\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54897,"post_author":"0","post_date":"2018-12-04 06:52:00","post_date_gmt":"2018-12-04 05:52:00","post_content":"","post_title":"Besson","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"besson","to_ping":"","pinged":"","post_modified":"2018-12-04 06:52:00","post_modified_gmt":"2018-12-04 05:52:00","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/besson\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50782,"post_author":"0","post_date":"2018-12-04 05:24:01","post_date_gmt":"2018-12-04 04:24:01","post_content":"","post_title":"Busserolles","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"busserolles","to_ping":"","pinged":"","post_modified":"2018-12-04 05:24:01","post_modified_gmt":"2018-12-04 04:24:01","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/busserolles\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50783,"post_author":"0","post_date":"2018-12-04 05:24:02","post_date_gmt":"2018-12-04 04:24:02","post_content":"","post_title":"Demigne","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"demigne","to_ping":"","pinged":"","post_modified":"2018-12-04 05:24:02","post_modified_gmt":"2018-12-04 04:24:02","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/demigne\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":50179,"post_author":"0","post_date":"2018-12-04 05:12:14","post_date_gmt":"2018-12-04 04:12:14","post_content":"","post_title":"Remesy","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"remesy","to_ping":"","pinged":"","post_modified":"2018-12-04 05:12:14","post_modified_gmt":"2018-12-04 04:12:14","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/remesy\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":45861,"post_author":"0","post_date":"2018-12-04 03:47:47","post_date_gmt":"2018-12-04 02:47:47","post_content":"","post_title":"Davicco","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"davicco","to_ping":"","pinged":"","post_modified":"2018-12-04 03:47:47","post_modified_gmt":"2018-12-04 02:47:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/davicco\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":12517,"post_author":"0","post_date":"2018-12-03 18:47:27","post_date_gmt":"2018-12-03 17:47:27","post_content":"","post_title":"A Mazur","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"a-mazur","to_ping":"","pinged":"","post_modified":"2018-12-03 18:47:27","post_modified_gmt":"2018-12-03 17:47:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/a-mazur\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":18247,"post_author":"0","post_date":"2018-12-03 20:02:21","post_date_gmt":"2018-12-03 19:02:21","post_content":"","post_title":"C Morand","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"c-morand","to_ping":"","pinged":"","post_modified":"2018-12-03 20:02:21","post_modified_gmt":"2018-12-03 19:02:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/c-morand\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54900,"post_author":"0","post_date":"2018-12-04 06:52:05","post_date_gmt":"2018-12-04 05:52:05","post_content":"","post_title":"Rayssiguier","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"rayssiguier","to_ping":"","pinged":"","post_modified":"2018-12-04 06:52:05","post_modified_gmt":"2018-12-04 05:52:05","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/rayssiguier\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":44294,"post_author":"0","post_date":"2018-12-04 03:21:12","post_date_gmt":"2018-12-04 02:21:12","post_content":"","post_title":"JOURNAL OF NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"journal-of-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:21:12","post_modified_gmt":"2018-12-04 02:21:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/journal-of-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel<\/title>\n<meta name=\"description\" content=\"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats\" \/>\n<meta property=\"og:description\" content=\"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/\",\"name\":\"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T05:52:06+00:00\",\"dateModified\":\"2018-12-04T05:52:06+00:00\",\"description\":\"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel","description":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats","og_description":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/","name":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T05:52:06+00:00","dateModified":"2018-12-04T05:52:06+00:00","description":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/lyophilized-apple-counteracts-the-development-of-hypercholesterolemia\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese zucker rats"}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/54901"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=54901"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=54901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}