{"id":54873,"date":"2002-12-01T00:00:00","date_gmt":"2018-12-04T05:51:34","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/"},"modified":"2018-12-04T06:51:34","modified_gmt":"2018-12-04T05:51:34","slug":"catechin-inhibits-platelet-hyperactivity-induced-by","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/","title":{"rendered":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo."},"content":{"rendered":"<p style=\"text-align: justify\">Reactive oxygen species and platelets are thought to be involved in the pathogenesis of cardiovascular disease. Epidemiological data have indicated that high consumption of fruits and vegetables is associated with a lower incidence of vascular events. Polyphenols were proposed to provide such a protection. In the present study performed in rats, we investigated the influence of (+)-catechin (Cat), a polyphenol identified in tea, cocoa, and red wine, on an acute iron load-induced model of platelet hyperactivity. We found that platelet function was significantly enhanced in iron-loaded rats. These changes were associated with impairment of the antioxidative defense including ex vivo free radical-induced hemolysis. Pretreatment with Cat (10 mg\/kg, ip, 4 d) normalized biomarkers of antioxidative status and platelet hyperactivity. The benefits of Cat treatment were only observed in iron-loaded animals and not in control animals. In light of the known antioxidant properties of Cat (or its metabolites), we suggest that oxidative injury-induced modification of platelet calcium homeostasis may have explained the iron load-induced platelet hyperactivity. The protective effect of Cat appears to work probably through normalization of the antioxidative status.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54873","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"BLACHE D,INSERM,U498;BLVD JEANNE ARC,BP 87900;F-21079 DIJON, FRANCE. blache@dijon.inra.fr","annee":"2002","mois":"12","numero":"33:12","page":"1670-1680","auteurs":[{"ID":54869,"post_author":"0","post_date":"2018-12-04 06:51:32","post_date_gmt":"2018-12-04 05:51:32","post_content":"","post_title":"Durand","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"durand","to_ping":"","pinged":"","post_modified":"2018-12-04 06:51:32","post_modified_gmt":"2018-12-04 05:51:32","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/durand\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54870,"post_author":"0","post_date":"2018-12-04 06:51:33","post_date_gmt":"2018-12-04 05:51:33","post_content":"","post_title":"Prost","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"prost","to_ping":"","pinged":"","post_modified":"2018-12-04 06:51:33","post_modified_gmt":"2018-12-04 05:51:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/prost\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54871,"post_author":"0","post_date":"2018-12-04 06:51:33","post_date_gmt":"2018-12-04 05:51:33","post_content":"","post_title":"Blache","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"blache","to_ping":"","pinged":"","post_modified":"2018-12-04 06:51:33","post_modified_gmt":"2018-12-04 05:51:33","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/blache\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54872,"post_author":"0","post_date":"2018-12-04 06:51:34","post_date_gmt":"2018-12-04 05:51:34","post_content":"","post_title":"Loreau","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"loreau","to_ping":"","pinged":"","post_modified":"2018-12-04 06:51:34","post_modified_gmt":"2018-12-04 05:51:34","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/loreau\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":43488,"post_author":"0","post_date":"2018-12-04 03:07:49","post_date_gmt":"2018-12-04 02:07:49","post_content":"","post_title":"FREE RADICAL BIOLOGY AND MEDICINE","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"free-radical-biology-and-medicine","to_ping":"","pinged":"","post_modified":"2018-12-04 03:07:49","post_modified_gmt":"2018-12-04 02:07:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/free-radical-biology-and-medicine\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel<\/title>\n<meta name=\"description\" content=\"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo.\" \/>\n<meta property=\"og:description\" content=\"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/\",\"name\":\"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T05:51:34+00:00\",\"dateModified\":\"2018-12-04T05:51:34+00:00\",\"description\":\"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel","description":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo.","og_description":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo.","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/","name":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T05:51:34+00:00","dateModified":"2018-12-04T05:51:34+00:00","description":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catechin-inhibits-platelet-hyperactivity-induced-by\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"(+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo."}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/54873"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=54873"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=54873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}