{"id":54828,"date":"2003-02-01T00:00:00","date_gmt":"2018-12-04T05:50:46","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-comparison-of-the-effect-of-advice-to-eat-either-5-a-day\/"},"modified":"2018-12-04T06:50:46","modified_gmt":"2018-12-04T05:50:46","slug":"a-comparison-of-the-effect-of-advice-to-eat-either-5-a-day","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/a-comparison-of-the-effect-of-advice-to-eat-either-5-a-day\/","title":{"rendered":"A comparison of the effect of advice to eat either &lsquo;5-a-day&rsquo; fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine"},"content":{"rendered":"<p><strong>OBJECTIVE:<\/strong><br \/>\nTo assess and compare the effects of natural folate (100 micro g) with those of folic acid from fortified sources (100 micro g\/day) on plasma folate and homocysteine.<\/p>\n<p><strong>DESIGN:<\/strong><br \/>\nRandomized controlled trial (parallel groups).<\/p>\n<p><strong>SETTING:<\/strong><br \/>\nMen and women living in South Wales, UK.<\/p>\n<p><strong>SUBJECTS:<\/strong><br \/>\nA total of 135 healthy individuals recruited from the local workforce and blood donor sessions. All subjects possessed the &#039;wild-type&#039; CC genotype for C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR).<\/p>\n<p><strong>INTERVENTIONS:<\/strong><br \/>\nSubjects underwent one of the following dietary interventions for 4 months: (1) fortified diet-usual diet plus 100 microg\/day folic acid from fortified foods; (2) natural folate diet-usual diet plus 100 microg\/day folate from natural sources; (3) control-usual diet.<\/p>\n<p><strong>RESULTS:<\/strong><br \/>\nThe fortified group increased reported intake of folic acid from fortified foods compared to other groups (P&lt;0.001) achieving an extra 98 microg\/day (95% CI 88-108). The natural folate group increased reported intake of natural source folates compared with the other two groups (P&lt;0.001), but achieved a mean increase of only 50 microg\/day (95% CI 34-66). Plasma folate increased (P&lt;0.01) by a similar amount in both intervention groups compared to controls (fortified group 2.97, 95% CI 0.8-5.1; natural group 2.76, 95% CI 0.6-4.9. Plasma homocysteine, vitamins B(6) and B(12) were not significantly changed.<\/p>\n<p><strong>CONCLUSIONS:<\/strong><br \/>\nSubjects achieved increases in folate intake using fortified foods more easily than by folate-rich foods, however both sources increased plasma folate by a similar amount. These levels of intake were insufficient to reduce homocysteine concentrations in MTHFR CC homozygotes, but may be more effective in other genotypes.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54828","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"MCDOWELL IFW,UNIV WALES COLL CARDIFF,COLL MED DEPT MED BIOCHEM;CF14 4XN CARDIFF S GLAM, WALES.ian.mcdowell@cardiffandvale.wales.nhs.uk","annee":"2003","mois":"2","numero":"57:2","page":"316-323","auteurs":[{"ID":45755,"post_author":"0","post_date":"2018-12-04 03:46:06","post_date_gmt":"2018-12-04 02:46:06","post_content":"","post_title":"Newcombe","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"newcombe","to_ping":"","pinged":"","post_modified":"2018-12-04 03:46:06","post_modified_gmt":"2018-12-04 02:46:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/newcombe\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":46370,"post_author":"0","post_date":"2018-12-04 03:56:38","post_date_gmt":"2018-12-04 02:56:38","post_content":"","post_title":"Burr","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"burr","to_ping":"","pinged":"","post_modified":"2018-12-04 03:56:38","post_modified_gmt":"2018-12-04 02:56:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/burr\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54824,"post_author":"0","post_date":"2018-12-04 06:50:44","post_date_gmt":"2018-12-04 05:50:44","post_content":"","post_title":"Clark","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"clark-5","to_ping":"","pinged":"","post_modified":"2018-12-04 06:50:44","post_modified_gmt":"2018-12-04 05:50:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/clark-5\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54825,"post_author":"0","post_date":"2018-12-04 06:50:44","post_date_gmt":"2018-12-04 05:50:44","post_content":"","post_title":"Mcdowell","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"mcdowell","to_ping":"","pinged":"","post_modified":"2018-12-04 06:50:44","post_modified_gmt":"2018-12-04 05:50:44","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/mcdowell\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":43574,"post_author":"0","post_date":"2018-12-04 03:09:10","post_date_gmt":"2018-12-04 02:09:10","post_content":"","post_title":"Ashfield Watt","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"ashfield-watt","to_ping":"","pinged":"","post_modified":"2018-12-04 03:09:10","post_modified_gmt":"2018-12-04 02:09:10","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/ashfield-watt\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54826,"post_author":"0","post_date":"2018-12-04 06:50:45","post_date_gmt":"2018-12-04 05:50:45","post_content":"","post_title":"Moat","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"moat","to_ping":"","pinged":"","post_modified":"2018-12-04 06:50:45","post_modified_gmt":"2018-12-04 05:50:45","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/moat\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54827,"post_author":"0","post_date":"2018-12-04 06:50:46","post_date_gmt":"2018-12-04 05:50:46","post_content":"","post_title":"Whiting","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"whiting","to_ping":"","pinged":"","post_modified":"2018-12-04 06:50:46","post_modified_gmt":"2018-12-04 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