{"id":54803,"date":"2002-09-01T00:00:00","date_gmt":"2018-12-04T05:50:22","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/"},"modified":"2018-12-04T06:50:22","modified_gmt":"2018-12-04T05:50:22","slug":"antioxidant-vitamins-and-risk-of-cardiovascular-disease","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/","title":{"rendered":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials"},"content":{"rendered":"

People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. Several large-scale trials were set up to assess whether beta-carotene supplementation might reduce the risk of cancer. Subsequently, evidence emerged from basic research which indicated that oxidative modification of low-density lipoprotein cholesterol increases its atherogenicity. The evidence from basic research, and epidemiological evidence for a possible protective effect of antioxidant vitamins for cardiovascular disease was strongest for vitamin E. More recently, further trials were set up to examine if supplementation with anti-oxidant vitamins might also reduce the risk of cardiovascular disease. This review summarises the available randomised evidence from published trials of beta-carotene supplementation involving 70,000 people from 3 large-scale trials in healthy populations and on vitamin E supplementation involving 29,000 patients at high-risk of cardiovascular disease from 5 large-scale trials. The results of these trials have been disappointing and failed to confirm any protective effect of these vitamins for either cancer or for cardiovascular disease.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54803","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"CLARKE R,RADCLIFFE INFIRM,CLIN TRIAL SERV UNIT;OX2 6HE OXFORD, ENGLAND. robert.clarke@ctsu.ox.ac.uk","annee":"2002","mois":"9","numero":"16:5","page":"411-415","auteurs":[{"ID":27809,"post_author":"0","post_date":"2018-12-03 22:58:12","post_date_gmt":"2018-12-03 21:58:12","post_content":"","post_title":"Christopher J Armitage","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"christopher-j-armitage","to_ping":"","pinged":"","post_modified":"2018-12-03 22:58:12","post_modified_gmt":"2018-12-03 21:58:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/christopher-j-armitage\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":28646,"post_author":"0","post_date":"2018-12-03 23:09:27","post_date_gmt":"2018-12-03 22:09:27","post_content":"","post_title":"Robert Clarke","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"robert-clarke","to_ping":"","pinged":"","post_modified":"2018-12-03 23:09:27","post_modified_gmt":"2018-12-03 22:09:27","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/robert-clarke\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":54802,"post_author":"0","post_date":"2018-12-04 06:50:21","post_date_gmt":"2018-12-04 05:50:21","post_content":"","post_title":"CARDIOVASCULAR DRUGS AND THERAPY","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cardiovascular-drugs-and-therapy","to_ping":"","pinged":"","post_modified":"2018-12-04 06:50:21","post_modified_gmt":"2018-12-04 05:50:21","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cardiovascular-drugs-and-therapy\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"\nAntioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel<\/title>\n<meta name=\"description\" content=\"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials\" \/>\n<meta property=\"og:description\" content=\"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials\" \/>\n<meta property=\"og:url\" content=\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Aprifel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/\",\"url\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/\",\"name\":\"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel\",\"isPartOf\":{\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\"},\"datePublished\":\"2018-12-04T05:50:22+00:00\",\"dateModified\":\"2018-12-04T05:50:22+00:00\",\"description\":\"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel\",\"breadcrumb\":{\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.aprifel.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9sum\u00e9s\",\"item\":\"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.aprifel.com\/fr\/#website\",\"url\":\"https:\/\/www.aprifel.com\/fr\/\",\"name\":\"Aprifel\",\"description\":\"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel","description":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel","robots":{"index":"noindex","follow":"follow"},"og_locale":"fr_FR","og_type":"article","og_title":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials","og_description":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials","og_url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/","og_site_name":"Aprifel","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/","url":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/","name":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel","isPartOf":{"@id":"https:\/\/www.aprifel.com\/fr\/#website"},"datePublished":"2018-12-04T05:50:22+00:00","dateModified":"2018-12-04T05:50:22+00:00","description":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials - Aprifel","breadcrumb":{"@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/antioxidant-vitamins-and-risk-of-cardiovascular-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.aprifel.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9sum\u00e9s","item":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/"},{"@type":"ListItem","position":3,"name":"Antioxidant vitamins and risk of cardiovascular disease. review of large-scale randomised trials"}]},{"@type":"WebSite","@id":"https:\/\/www.aprifel.com\/fr\/#website","url":"https:\/\/www.aprifel.com\/fr\/","name":"Aprifel","description":"Agence pour la Recherche et l\u2019Information en Fruits et L\u00e9gumes","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.aprifel.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"_links":{"self":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume\/54803"}],"collection":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/resume"}],"about":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/types\/resume"}],"wp:attachment":[{"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/media?parent=54803"}],"wp:term":[{"taxonomy":"mots_cles","embeddable":true,"href":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/wp-json\/wp\/v2\/mots_cles?post=54803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}