{"id":54799,"date":"2002-12-01T00:00:00","date_gmt":"2018-12-04T05:50:16","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-7-beta-hydroxycholesterol-as-a-possible-predictor\/"},"modified":"2018-12-04T06:50:16","modified_gmt":"2018-12-04T05:50:16","slug":"plasma-7-beta-hydroxycholesterol-as-a-possible-predictor","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/plasma-7-beta-hydroxycholesterol-as-a-possible-predictor\/","title":{"rendered":"Plasma 7 beta-hydroxycholesterol as a possible predictor of lung cancer risk"},"content":{"rendered":"<p>Epidemiological data suggests a role of dietary cholesterol in the etiology of lung cancer without having a clear biological hypothesis. Although smoking as the outstanding risk factor for lung cancer may enhance lipid peroxidation reactions, this study was planned to assess smoking-independent associations between the extent of cholesterol oxidation and the risk for lung cancer. In the frame of a nested case-control study in European Prospective Investigation on Cancer-Heidelberg, six cholesterol oxidation products (COPs) were determined in plasma samples of 20 incident lung cancer patients obtained 1.9 +\/- 0.6 years before diagnosis and in 40 matched (including smoking habits) controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression. Among all COP compounds tested, plasma 7beta-hydroxycholesterol was associated with lung cancer risk. The high crude risk estimate (OR similar to 5) became significant after adjustment for sports activity (OR = 6.83, CI = 1.08-43.01, 3rd versus 1st tertile). For the independent effect of 7beta-hydroxycholesterol, i.e., adjusted for other COP compounds, an OR of 8.08 (CI = 1.12-58.54, 3rd versus 1st tertile) was calculated (P = 0.04 for trend). Lung cancer risk adjusted for sports activity significantly increased by 26% (CI = 1.050-1.506, P = 0.01) per unit (1 nmol\/mmol plasma cholesterol) of 7beta-hydroxycholesterol. No dietary factor had a significant effect in the regression model, but the dietary intake of meat, eggs, animal fat, cholesterol, and fruits (inversely) correlated with plasma COP concentrations. In this small study, plasma 7beta-hydroxycholesterol appeared to be a smoking-independent predictor of lung cancer risk and might therefore be used as a biomarker. Because of the rather high-risk estimate, research on possible intrinsic biological effects of this compound should be encouraged.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54799","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"LINSEISEN J,TECH UNIV MUNICH,UNIT HUMAN NUTR & CANC PREVENT;ALTE AKADEMIE 16;D-85350 FREISING WEIHENSTEPHAN, GERMANY.bj.linseisen@wzw.tum.de  \"","annee":"2002","mois":"12","numero":"11:12","page":"1630-1637","auteurs":[{"ID":41966,"post_author":"0","post_date":"2018-12-04 02:41:26","post_date_gmt":"2018-12-04 01:41:26","post_content":"","post_title":"Miller","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"miller","to_ping":"","pinged":"","post_modified":"2018-12-04 02:41:26","post_modified_gmt":"2018-12-04 01:41:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/miller\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":25314,"post_author":"0","post_date":"2018-12-03 22:16:46","post_date_gmt":"2018-12-03 21:16:46","post_content":"","post_title":"Jakob Linseisen","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jakob-linseisen","to_ping":"","pinged":"","post_modified":"2018-12-03 22:16:46","post_modified_gmt":"2018-12-03 21:16:46","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jakob-linseisen\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54798,"post_author":"0","post_date":"2018-12-04 06:50:16","post_date_gmt":"2018-12-04 05:50:16","post_content":"","post_title":"Wolfram","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"wolfram-2","to_ping":"","pinged":"","post_modified":"2018-12-04 06:50:16","post_modified_gmt":"2018-12-04 05:50:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/wolfram-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":1195,"post_author":"0","post_date":"2018-12-03 15:57:12","post_date_gmt":"2018-12-03 14:57:12","post_content":"","post_title":"CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-epidemiology-biomarkers-and-prevention","to_ping":"","pinged":"","post_modified":"2018-12-03 15:57:12","post_modified_gmt":"2018-12-03 14:57:12","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-epidemiology-biomarkers-and-prevention\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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