{"id":54775,"date":"2003-01-01T00:00:00","date_gmt":"2018-12-04T05:49:49","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/anticancer-and-antiinflammatory-activities-of-cucurbitacins\/"},"modified":"2018-12-04T06:49:49","modified_gmt":"2018-12-04T05:49:49","slug":"anticancer-and-antiinflammatory-activities-of-cucurbitacins","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/anticancer-and-antiinflammatory-activities-of-cucurbitacins\/","title":{"rendered":"Anticancer and antiinflammatory activities of cucurbitacins from cucurbita andreana"},"content":{"rendered":"<p style=\"text-align: justify\">Bioassay-guided purification of an extract of Cucurbita andreana fruits yielded cucurbitacins B (1), D (2), E (3), and 1 (4). These cucurbitacins were evaluated for their inhibitory effects on the growth of human colon (HCT-116), breast (MCF-7), lung (NCI-H460), and central nervous system (CNS) (SF-268) cancer cell lines, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes and on lipid peroxidation. Inhibitory activities of cucurbitacins B (1), D (2), E (3) and 1 (4), respectively, were for colon 81.5, 80.4, 7, and 65% at 0.4 muM, breast 87, 78, 66.5, and 12% at 0.4 muM, lung 96,43, 37 and 2% at 0.1 muM and CNS 92, 25, 24 and 4% at 0.05 muM. Adriamycin (doxorubicin) was used as a positive control, which showed 64,47,45 and 71% inhibition of HCT-116 (colon), MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) cell lines, respectively, at 0.3 x 10(-5) M. Compounds 1, 2, 3, and 4 inhibited the COX-2 enzyme by 32, 29, 35, and 27%, respectively, at 100 mug\/ml. However these compounds did not inhibit the COX-1 enzyme at this concentration. Ibuprofen, naproxen and vioxx, commercial antiinflammatory drugs, were tested as controls for the inhibition of COX-1 and COX-2 enzymes at concentrations of 2.1, 2.5 and 1.67 mug\/ml, respectively. Ibuprofen and naproxen exhibited 59 and 95% COX-1, and 53 and 79% COX-2 inhibitory activities, respectively. Vioxx showed specific COX-2 inhibition by 71%. Also, cucurbitacins 1 and 4 inhibited lipid peroxidation by 59 and 23%, respectively, at 100 mug\/ml.<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54775","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"MICHIGAN STATE UNIV,DEPT HORT; E LANSING MI 48824, USA. nairm@msu.edu","annee":"2003","mois":"1","numero":"189:1","page":"11-16","auteurs":[{"ID":1647,"post_author":"0","post_date":"2018-12-03 16:01:16","post_date_gmt":"2018-12-03 15:01:16","post_content":"","post_title":"Navindra P Seeram","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"navindra-p-seeram","to_ping":"","pinged":"","post_modified":"2018-12-03 16:01:16","post_modified_gmt":"2018-12-03 15:01:16","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/navindra-p-seeram\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":49178,"post_author":"0","post_date":"2018-12-04 04:52:19","post_date_gmt":"2018-12-04 03:52:19","post_content":"","post_title":"Jayaprakasam","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jayaprakasam","to_ping":"","pinged":"","post_modified":"2018-12-04 04:52:19","post_modified_gmt":"2018-12-04 03:52:19","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jayaprakasam\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":44212,"post_author":"0","post_date":"2018-12-04 03:19:38","post_date_gmt":"2018-12-04 02:19:38","post_content":"","post_title":"Nair","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nair-2","to_ping":"","pinged":"","post_modified":"2018-12-04 03:19:38","post_modified_gmt":"2018-12-04 02:19:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nair-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":8255,"post_author":"0","post_date":"2018-12-03 17:58:06","post_date_gmt":"2018-12-03 16:58:06","post_content":"","post_title":"CANCER LETTERS","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"cancer-letters","to_ping":"","pinged":"","post_modified":"2018-12-03 17:58:06","post_modified_gmt":"2018-12-03 16:58:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/cancer-letters\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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