{"id":54771,"date":"2003-01-01T00:00:00","date_gmt":"2018-12-04T05:49:43","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-dietary-antioxidants-on-postprandial-endothelial\/"},"modified":"2018-12-04T06:49:43","modified_gmt":"2018-12-04T05:49:43","slug":"effect-of-dietary-antioxidants-on-postprandial-endothelial","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/effect-of-dietary-antioxidants-on-postprandial-endothelial\/","title":{"rendered":"Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects"},"content":{"rendered":"<p>\u00ab\u00a0Background: Persons following current dietary guidelines have a lower risk of mortality from coronary heart disease.Objective: The objective was to compare the short-term effect of a high-fat meal and a high-carbohydrate meal, with and without dietary antioxidants, on vasomotor, antiplatelet, and hemostatic functions of the endothelium in healthy subjects.Design: In an observer-blinded, randomized crossover study, 25 (13 men and 12 women) healthy subjects were given each of 3 meals in random order at 1-wk intervals: a high-fat meal (760 kcal), an isoenergetic high-carbohydrate meal, and a high-fat meal with dietary antioxidants from vegetables (865 kcal). Endothelial functions, as assessed by hemodynamic and rheologic responses to L-arginine-the natural precursor of nitric oxide-were evaluated before and 4 h after each meal.Results: Unlike the high-carbohydrate meal, the high-fat meal increased the plasma concentrations of triacylglycerol (P &lt; 0.01); both meals activated hemostasis. The high-carbohydrate meal did not modify blood pressure, and platelet aggregation decreased in response to the L-arginine load (-7.1 +\/- 2.3 mm Hg and -8.5 +\/- 4.5%, respectively). After the high-fat meal, the decrease in blood pressure in response to L-arginine was reduced (-1 +\/- 0.8 mm Hg), and platelet aggregation showed a paradoxical increase (4.1 +\/- 2.1%; P &lt; 0.01 compared with the high-carbohydrate meal). The high-fat meal with antioxidants partially restored the vascular response to L-arginine.Conclusion: Compared with a high-carbohydrate meal, a high-fat meal can modify endothelial functions toward a more atherogenetic profile, which is partially prevented by dietary antioxidants.&quot;<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54771","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"GIUGLIANO D;VIA VENEZIA 14-B;I-80021 AFRAGOLA NA, ITALY. dario.giugliano@unina2.it \"","annee":"2003","mois":"1","numero":"77:1","page":"139-143","auteurs":[{"ID":9279,"post_author":"0","post_date":"2018-12-03 18:09:23","post_date_gmt":"2018-12-03 17:09:23","post_content":"","post_title":"Katherine Esposito","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"katherine-esposito","to_ping":"","pinged":"","post_modified":"2018-12-03 18:09:23","post_modified_gmt":"2018-12-03 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04:45:38","post_content":"","post_title":"Marfella","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"marfella","to_ping":"","pinged":"","post_modified":"2018-12-04 05:45:38","post_modified_gmt":"2018-12-04 04:45:38","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/marfella\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54769,"post_author":"0","post_date":"2018-12-04 06:49:42","post_date_gmt":"2018-12-04 05:49:42","post_content":"","post_title":"Nappo","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"nappo","to_ping":"","pinged":"","post_modified":"2018-12-04 06:49:42","post_modified_gmt":"2018-12-04 05:49:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/nappo\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":40939,"post_author":"0","post_date":"2018-12-04 02:24:24","post_date_gmt":"2018-12-04 01:24:24","post_content":"","post_title":"Giugliano","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"giugliano","to_ping":"","pinged":"","post_modified":"2018-12-04 02:24:24","post_modified_gmt":"2018-12-04 01:24:24","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/giugliano\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54770,"post_author":"0","post_date":"2018-12-04 06:49:43","post_date_gmt":"2018-12-04 05:49:43","post_content":"","post_title":"Guigliano","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"guigliano","to_ping":"","pinged":"","post_modified":"2018-12-04 06:49:43","post_modified_gmt":"2018-12-04 05:49:43","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/guigliano\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":44192,"post_author":"0","post_date":"2018-12-04 03:19:18","post_date_gmt":"2018-12-04 02:19:18","post_content":"","post_title":"AMERICAN JOURNAL OF CLINICAL NUTRITION","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"american-journal-of-clinical-nutrition","to_ping":"","pinged":"","post_modified":"2018-12-04 03:19:18","post_modified_gmt":"2018-12-04 02:19:18","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/american-journal-of-clinical-nutrition\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects - Aprifel<\/title>\n<meta name=\"description\" content=\"Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a high-fat meal in healthy subjects - Aprifel\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effect of dietary antioxidants on postprandial endothelial dysfunction induced by a 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