{"id":54643,"date":"2002-12-01T00:00:00","date_gmt":"2018-12-04T05:47:49","guid":{"rendered":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catalysis-of-catechol-oxidation-by-metal-dithiocarbamate\/"},"modified":"2018-12-04T06:47:49","modified_gmt":"2018-12-04T05:47:49","slug":"catalysis-of-catechol-oxidation-by-metal-dithiocarbamate","status":"publish","type":"resume","link":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/resume-scientifique\/catalysis-of-catechol-oxidation-by-metal-dithiocarbamate\/","title":{"rendered":"Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides"},"content":{"rendered":"<p>\u00ab\u00a0Dithiocarbamate (DTC)-based pesticides have been implicated in Parkinson&rsquo;s disease (PD) through epidemiological links to increased risk of PD, clinical reports of parkinsonism following occupational exposure to the DTC-based pesticide maneb, and experimental studies showing dopaminergic neurodegeneration with combined exposure of rats to maneb and paraquat. We hypothesize that the manganese-ethylene-bis-dithiocarbamate (MnEBDC) complex in maneb may produce oxidative stress by catalyzing catechol oxidation. We tested this hypothesis by performing a structure-function analysis of metal-EBDC and metal-diethyldithiocarbamate (DEDC) complexes of Mn2+, Zn2+, and Cu2+ to catalyze oxidation of N-acetyldopamine (NA-DA) and 3,4-dihydroxyphenyl acetic acid (DP) in the presence and absence of N-acetylcysteine (NAC), a model of glutathione. Both Mn-DTCs retained the capacity of the parent ion to catalyze one-electron oxidation of NA-DA, but lost the ability to catalyze DP oxidation. Strikingly, while Zn2+ did not catalyze catechol oxidation, both Zn-DTCs catalyzed one-electron oxidation of NA-DA but not DP. While Cu2+ catalyzed oxidation of both catechols, Cu-DTCs were inert. Similar results were obtained with MnEBDC and dopamine or norepinephrine; however, zinc-ethylene-bis-dithiocarbamate was less efficient at catalyzing oxidation of these catechols. Our results point to the potential for manganese- and zinc-containing EBDC pesticides to promote oxidative stress in catecholaminergic regions of the brain.\u00a0\u00bb<\/p>\n","protected":false},"template":"","mots_cles":[],"class_list":["post-54643","resume","type-resume","status-publish","hentry"],"acf":{"adresse":"\"MONTINE TJ,UNIV WASHINGTON,HARBORVIEW MED CTR DEPT PATHOL;BOX 359791,325 9TH AVE; SEATTLE WA 98104, USA.tmontine@u.washington.edu \"","annee":"2002","mois":"12","numero":"33:12","page":"1714-1723","auteurs":[{"ID":6847,"post_author":"0","post_date":"2018-12-03 17:42:36","post_date_gmt":"2018-12-03 16:42:36","post_content":"","post_title":"Jun Zhang","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"jun-zhang","to_ping":"","pinged":"","post_modified":"2018-12-03 17:42:36","post_modified_gmt":"2018-12-03 16:42:36","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/jun-zhang\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54638,"post_author":"0","post_date":"2018-12-04 06:47:46","post_date_gmt":"2018-12-04 05:47:46","post_content":"","post_title":"Amarnath","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"amarnath","to_ping":"","pinged":"","post_modified":"2018-12-04 06:47:46","post_modified_gmt":"2018-12-04 05:47:46","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/amarnath\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54639,"post_author":"0","post_date":"2018-12-04 06:47:47","post_date_gmt":"2018-12-04 05:47:47","post_content":"","post_title":"Fitsanakis","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"fitsanakis","to_ping":"","pinged":"","post_modified":"2018-12-04 06:47:47","post_modified_gmt":"2018-12-04 05:47:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/fitsanakis\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54640,"post_author":"0","post_date":"2018-12-04 06:47:47","post_date_gmt":"2018-12-04 05:47:47","post_content":"","post_title":"Montine","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"montine","to_ping":"","pinged":"","post_modified":"2018-12-04 06:47:47","post_modified_gmt":"2018-12-04 05:47:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/montine\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54641,"post_author":"0","post_date":"2018-12-04 06:47:48","post_date_gmt":"2018-12-04 05:47:48","post_content":"","post_title":"Montine","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"montine-2","to_ping":"","pinged":"","post_modified":"2018-12-04 06:47:48","post_modified_gmt":"2018-12-04 05:47:48","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/montine-2\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":54642,"post_author":"0","post_date":"2018-12-04 06:47:49","post_date_gmt":"2018-12-04 05:47:49","post_content":"","post_title":"Moore","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"moore-7","to_ping":"","pinged":"","post_modified":"2018-12-04 06:47:49","post_modified_gmt":"2018-12-04 05:47:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/auteur\/moore-7\/","menu_order":0,"post_type":"auteur_resume","post_mime_type":"","comment_count":"0","filter":"raw"}],"sources":[{"ID":43488,"post_author":"0","post_date":"2018-12-04 03:07:49","post_date_gmt":"2018-12-04 02:07:49","post_content":"","post_title":"FREE RADICAL BIOLOGY AND MEDICINE","post_excerpt":"","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"free-radical-biology-and-medicine","to_ping":"","pinged":"","post_modified":"2018-12-04 03:07:49","post_modified_gmt":"2018-12-04 02:07:49","post_content_filtered":"","post_parent":0,"guid":"https:\/\/aprifel-pp.mentalworks.biz\/fr\/source\/free-radical-biology-and-medicine\/","menu_order":0,"post_type":"source","post_mime_type":"","comment_count":"0","filter":"raw"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.6 (Yoast SEO v23.6) - 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